Navigation Links
Genes identified that are linked to spinal disc degeneration
Date:3/12/2009

Lumbar disc degeneration is an uncomfortable condition that affects millions of people, but two University of Alberta researchers have identified some of the genes that are causing problems.

Michele Crites-Battie and Tapio Videman, in the Faculty of Rehabilitation Medicine, have discovered eight genes that are directly related to disc degeneration.

"We found more genes associated with disc degeneration than was discovered in 30 prior studies," said Videman. "This is very exciting."

The pair started by studying 25 specific genes they thought could be linked to the disease.

They picked these "candidate" genes based on the views of two leading experts in the field who Crites-Battie and Videman have collaborated with through the years. They narrowed their search down using state-of-the-art DNA analyzers, then applying statistical methods and analyzing MRIs of twins' spines.

"Identifying genes involved can provide important insights into the biological mechanisms behind disc degeneration and a better understanding of what is going wrong in the system," said Crites-Battie. "This can eventually lead to effective interventions for the problem."

The pair will now look at the interaction between these eight genes and their environment. This will help them identify what gene forms indicate susceptibility.

"This will tell us who should avoid physical loading, and in which people obesity could be a risk factor for spine problems," said Videman.

But this could be a long process as disc degeneration is what's called polygenic, meaning it involves more than one gene.

"There are likely to be quite a number of genes involved and a system of complex gene-gene and gene-environment interactions," said Crites-Battie. "Obtaining a full appreciation of the genetic architecture of disc degeneration is likely to be a very lengthy, involved process."

This discovery comes about a year after the pair's award winning 10-year international twin-spine study proved that disc degeneration is affected largely by genetics.

"For years it has been thought that wear and tear was the main cause," said Crites-Battie.

The U of A researchers have made huge strides in the field and are determined to put an end to lower-back pain.

"This study could lead to interventions and actions individuals could take to minimize disc degeneration to which [patients] might be particularly prone," said Crites-Battie. "We are very excited about continuing down this trail and believe there is still much more to be learned."


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-492-0436
University of Alberta
Source:Eurekalert

Related biology news :

1. Cleft lip and palate: Genes more important than thought?
2. Magnetic nanoparticles navigate therapeutic genes through the body
3. It takes a genome: How a clash between our genes and modern life is making us sick
4. UCR scientists identify stem-cell genes that help form plant organs
5. NC State study finds genes important to sleep
6. New data suggest jumping genes play a significant role in gene regulatory networks
7. 2 genes influence social behavior, visual-spatial performance in people with Williams syndrome
8. Scientists uncover new class of non-protein coding genes in mammals with key functions
9. Missing genes link to psoriasis
10. Large DNA stretches, not single genes, shut off as cells mature
11. U-M researchers discover new genes that fuse in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical ... Office of the National Coordinator for Health IT (ONC) outlining a measurement approach ... data were available when and where it was needed. The organization of health ...
(Date:5/25/2016)... , ... May 25, 2016 , ... WEDI, the nation’s ... exchange, today announced that Charles W. Stellar has been named by the WEDI Board ... since January 2016. As an executive leader with more than 35 years of experience ...
(Date:5/25/2016)... Connecticut (PRWEB) , ... May 25, 2016 , ... ... the U.S. Food and Drug Administration (FDA) has granted the company’s orphan drug ... the company’s second orphan drug designation granted by the FDA. , Spinocerebellar ...
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
Breaking Biology Technology: