Navigation Links
Genes identified that are linked to spinal disc degeneration
Date:3/12/2009

Lumbar disc degeneration is an uncomfortable condition that affects millions of people, but two University of Alberta researchers have identified some of the genes that are causing problems.

Michele Crites-Battie and Tapio Videman, in the Faculty of Rehabilitation Medicine, have discovered eight genes that are directly related to disc degeneration.

"We found more genes associated with disc degeneration than was discovered in 30 prior studies," said Videman. "This is very exciting."

The pair started by studying 25 specific genes they thought could be linked to the disease.

They picked these "candidate" genes based on the views of two leading experts in the field who Crites-Battie and Videman have collaborated with through the years. They narrowed their search down using state-of-the-art DNA analyzers, then applying statistical methods and analyzing MRIs of twins' spines.

"Identifying genes involved can provide important insights into the biological mechanisms behind disc degeneration and a better understanding of what is going wrong in the system," said Crites-Battie. "This can eventually lead to effective interventions for the problem."

The pair will now look at the interaction between these eight genes and their environment. This will help them identify what gene forms indicate susceptibility.

"This will tell us who should avoid physical loading, and in which people obesity could be a risk factor for spine problems," said Videman.

But this could be a long process as disc degeneration is what's called polygenic, meaning it involves more than one gene.

"There are likely to be quite a number of genes involved and a system of complex gene-gene and gene-environment interactions," said Crites-Battie. "Obtaining a full appreciation of the genetic architecture of disc degeneration is likely to be a very lengthy, involved process."

This discovery comes about a year after the pair's award winning 10-year international twin-spine study proved that disc degeneration is affected largely by genetics.

"For years it has been thought that wear and tear was the main cause," said Crites-Battie.

The U of A researchers have made huge strides in the field and are determined to put an end to lower-back pain.

"This study could lead to interventions and actions individuals could take to minimize disc degeneration to which [patients] might be particularly prone," said Crites-Battie. "We are very excited about continuing down this trail and believe there is still much more to be learned."


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-492-0436
University of Alberta
Source:Eurekalert

Related biology news :

1. Cleft lip and palate: Genes more important than thought?
2. Magnetic nanoparticles navigate therapeutic genes through the body
3. It takes a genome: How a clash between our genes and modern life is making us sick
4. UCR scientists identify stem-cell genes that help form plant organs
5. NC State study finds genes important to sleep
6. New data suggest jumping genes play a significant role in gene regulatory networks
7. 2 genes influence social behavior, visual-spatial performance in people with Williams syndrome
8. Scientists uncover new class of non-protein coding genes in mammals with key functions
9. Missing genes link to psoriasis
10. Large DNA stretches, not single genes, shut off as cells mature
11. U-M researchers discover new genes that fuse in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... -- Delta ID Inc., a leader in consumer-grade iris scanning ... CES® 2017. Delta ID has collaborated with Gentex Corporation ... of iris scanning as a secure, reliable and convenient ... car, and as a way to elevate the security ... ID and Gentex will demonstrate (booth #7326 LVCC) a ...
(Date:12/22/2016)... SuperCom (NASDAQ:   SPCB ), ... HealthCare, and Finance sectors announced today that Leaders in Community Alternatives ... deploy a community-based supportive services program to reduce recidivism in a ... its presence in the state. ... This new program, which is expected to commence in ...
(Date:12/16/2016)... Dec 16, 2016 Research and Markets has ... - Global Forecast to 2021" report to their offering. ... The biometric vehicle ... at a CAGR of 14.06% from 2016 to 2021. The market ... projected to reach 854.8 Million by 2021. The growth of the ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... Staten Island, NY (PRWEB) , ... January 19, 2017 , ... ... expand at an exponential rate. The tremendous growth is accounted to two main ... to the table and the expanding network of vendors supplying FireflySci products all around ...
(Date:1/19/2017)... Md. , Jan. 18, 2017  Northwest Biotherapeutics, ... developing DCVax® personalized immune therapies for operable and inoperable ... Bosch , Chief Technical Officer of NW Bio, will ... January 19, 2017, at the Hyatt Regency Hotel in ... Bosch will chair the session entitled "New Therapeutic Approaches ...
(Date:1/18/2017)... ... 2017 , ... Opal Kelly, a leading producer of powerful ... the ZEM5310 USB 3.0 FPGA Module, combining a SuperSpeed USB 3.0 interface and ... suitable for prototyping, testing, and production-ready integration. The ZEM5310 USB interface delivers real-world ...
(Date:1/18/2017)... Jan. 18, 2017 Applied BioMath ( ... to drug research and development, today announced that ... and CEO of Applied BioMath, will present at ... Modeling (BAGIM) Meeting on Thursday January 19, 2017 ... , MA.   Dr. Burke,s talk "Quantitative Modeling ...
Breaking Biology Technology: