Navigation Links
Genes found linked to breast cancer drug resistance could guide future treatment choices
Date:1/24/2010

utcomes than those without the culprit gene signature.

However, the overexpression of the two genes did not protect laboratory-grown breast cancer cells against other classes of drugs, including paclitaxel and cisplatin, reported Richardson, Wang, and the first author, Yang Li, PhD.

"These results suggest that tumors resistant to anthracyclines may still be sensitive to other agents," said Richardson, who is also on faculty at Brigham and Women's Hospital and Harvard Medical School. "So this would be very useful as a test to help pick the therapy that's going to be most effective for these patients."

Such a tool should not be difficult to develop, she said, and could be available for clinical testing within a year or two.

It's been known that some breast tumors acquire, during the course of treatment, altered genes or chromosomes that make them resistant to many cancer drugs. But with one or two exceptions, "No tests are done before treatment begins to predict who's going to be resistant or sensitive to different compounds," says Richardson. "Most breast cancer patients are initially given the same drugs."

Exceptions include patients whose tumors are spurred by estrogen and are often less sensitive to any chemotherapy; hormonal treatment is generally prescribed in that case. Also, breast cancers found to be HER2-positive are treated with the antibody trastuzumab another example of "personalized" or tailored therapy.

In search of genetic alterations that might explain disease recurrence despite treatment with adjuvant chemotherapy in some breast cancer patients, the Dana-Farber scientists scanned the genome (all the DNA) of stored breast cancer samples from patients who had been treated according to modern guidelines, including the use of anthracyclines. The samples had been taken in the operating room during breast surgery before any drug therapy had begun and thus enabled the scientists to look for DNA alter
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. In early heart development, genes work in tandem
2. Why do people play the longshot and buy insurance? Its in our genes
3. Genes for drought-tolerance, aflatoxin may mingle to boost corn production
4. New RNA interference technique can silence up to 5 genes
5. There may be a party in your genes
6. New genes for lung disease discovered
7. Extreme genes shed light on origins of photosynthesis
8. Happy holidays from the groaning board; Western diets turn on fat genes
9. Maize cell wall genes identified, giving boost to biofuel research
10. Largest gene study of childhood IBD identifies 5 new genes
11. Longevity tied to genes that preserve tips of chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Medicine, Inc, a Baltimore-based bioinformatics company focused on ... a research collaboration with the international leader in ... CSBR). , "There are many companies utilizing advances ... TumorGraft technology is unique in a way that ... vast amounts of valuable data. Our bioinformatic analysis ...
(Date:11/4/2014)... the right time might actually help boost a species, ... in understanding animal populations, pest control and managing fish ... journal Trends in Ecology and Evolution , a ... kind of positive population effect an overall species experiences ... the size and developmental stage of the creatures that ...
(Date:11/4/2014)... – A majority of Madagascar,s 101 species of lemurs ... consequences for the rainforests they call home. A new ... lemurs can have on rainforest tree populations, which raises ... on the region,s rich biodiversity. , A large proportion ... lemurs. Lemurs in turn disperse the seeds of ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2When less is more: Death in moderation boosts population density in nature 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... could lead to a novel approach to the treatment of ... Health Science Center at Houston report they are the first ... disease (COPD). Findings appear online and will be in the ... the journal of The Federation of American Societies for Experimental ...
... are developing technologies that use lasers to create arterial ... 10 times faster and also less expensively than is ... meet the huge global market for artificial hips and ... and director of Purdue,s Center for Laser-Based Manufacturing. ...
... ADHD, is one of the most common neuropsychiatric ... affected with the disorder. Key symptoms of ADHD ... reduced ability to focus attention. Clinically, three different ... a primarily hyperactive/impulsive subtype, and a combined subtype ...
Cached Biology News:UT scientists discover link between protein and lung disease 2Laser processes promise better artificial joints, arterial stents 2Laser processes promise better artificial joints, arterial stents 3The role of genetic factors in adult ADHD 2The role of genetic factors in adult ADHD 3The role of genetic factors in adult ADHD 4The role of genetic factors in adult ADHD 5The role of genetic factors in adult ADHD 6
(Date:11/26/2014)... (PRWEB) November 25, 2014 SonaCare ... Focused Ultrasound (HIFU) devices, recently participated in the ... Renal Mass 360° .” Key opinion leaders in ... advances related to small renal masses while attendees ... different ablative technologies in hands-on labs. Attendees at ...
(Date:11/26/2014)... Pittsburgh, PA (PRWEB) November 25, 2014 ... release of its official conference and exposition mobile app, ... available for free download in the App Store for ... as a valuable resource tool before, during and after ... guide containing details on exhibiting companies, technical sessions, Conferee ...
(Date:11/26/2014)... SoundConnect , an award winning unified ... that Darren Suders has joined the team as Director ... the partner program through innovative offerings, consistent ... Darren brings more than 10-years of channel telecommunication experience ... operations, from policy development, to partner education and to ...
(Date:11/26/2014)... Theravalues Corporation est fier d,annoncer le ... au salon Hi Europe 2014 (du 2 au ... Curcumine la plus biodisponible actuellement sur le ... des ingrédients approuvés par les règlements européens. ... dans la racine de curcuma ( Curcuma longa ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3
... NOIDA, India, Jan. 21 Jubilant Organosys Ltd,headquartered ... its subsidiary,Jubilant Biosys Ltd., based in Bangalore, has ... will further enable the process of,high throughput screening, ... launched in the US and Europe initially, allows ...
... Germany and STOCKHOLM, January 21 Richter-Helm,BioLogics GmbH ... signed an,agreement for the development and manufacturing of ... athero-thrombosis through binding of the,protein, Annexin A5, to ... the treatment of patients with Acute Coronary Syndrome ...
... AMGN ) today announced that it plans to ... Monday, Jan. 26, 2009 after the close of the financial ... with the investment community at 2:00 p.m. Pacific Time. ... chairman and chief executive officer, and other members of Amgen,s ...
Cached Biology Technology:Jubilant Biosys Launches Legend NGSS(TM) Advanced Software Solution for High-Throughput Drug Molecule Screening 2Richter-Helm and Athera Biotechnologies Partner in Development of Recombinant Protein to Treat Cardiovascular Disease 2Richter-Helm and Athera Biotechnologies Partner in Development of Recombinant Protein to Treat Cardiovascular Disease 3Amgen Announces Webcast of 2008 Fourth Quarter and Full Year Financial Results 2
... The kit provides a simple and efficient method ... and from PCR mixes. DNA fragments selectively absorbed ... for gel extraction or at room temperature for ... Up to 25 g of DNA can be ...
This kit is designed to select cells labeled with fluorescein isothiocyanate- (FITC-) conjugated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
... Fujifilm Life Science BAS-5000 is the ... Plate equipment. The top member of ... features a superior Imaging Plate (IP) ... in target subjects. Fujifilm BAS-5000 does ...
Biology Products: