Navigation Links
Genes found linked to breast cancer drug resistance could guide future treatment choices
Date:1/24/2010

utcomes than those without the culprit gene signature.

However, the overexpression of the two genes did not protect laboratory-grown breast cancer cells against other classes of drugs, including paclitaxel and cisplatin, reported Richardson, Wang, and the first author, Yang Li, PhD.

"These results suggest that tumors resistant to anthracyclines may still be sensitive to other agents," said Richardson, who is also on faculty at Brigham and Women's Hospital and Harvard Medical School. "So this would be very useful as a test to help pick the therapy that's going to be most effective for these patients."

Such a tool should not be difficult to develop, she said, and could be available for clinical testing within a year or two.

It's been known that some breast tumors acquire, during the course of treatment, altered genes or chromosomes that make them resistant to many cancer drugs. But with one or two exceptions, "No tests are done before treatment begins to predict who's going to be resistant or sensitive to different compounds," says Richardson. "Most breast cancer patients are initially given the same drugs."

Exceptions include patients whose tumors are spurred by estrogen and are often less sensitive to any chemotherapy; hormonal treatment is generally prescribed in that case. Also, breast cancers found to be HER2-positive are treated with the antibody trastuzumab another example of "personalized" or tailored therapy.

In search of genetic alterations that might explain disease recurrence despite treatment with adjuvant chemotherapy in some breast cancer patients, the Dana-Farber scientists scanned the genome (all the DNA) of stored breast cancer samples from patients who had been treated according to modern guidelines, including the use of anthracyclines. The samples had been taken in the operating room during breast surgery before any drug therapy had begun and thus enabled the scientists to look for DNA alter
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. In early heart development, genes work in tandem
2. Why do people play the longshot and buy insurance? Its in our genes
3. Genes for drought-tolerance, aflatoxin may mingle to boost corn production
4. New RNA interference technique can silence up to 5 genes
5. There may be a party in your genes
6. New genes for lung disease discovered
7. Extreme genes shed light on origins of photosynthesis
8. Happy holidays from the groaning board; Western diets turn on fat genes
9. Maize cell wall genes identified, giving boost to biofuel research
10. Largest gene study of childhood IBD identifies 5 new genes
11. Longevity tied to genes that preserve tips of chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... at New York University is paving the way ... in civilians and military troops exposed to poisonous ... , An article in the current issue of ... in detoxifying organophosphates, which are compounds commonly used ... was developed by NYU School of Engineering Associate ...
(Date:7/30/2014)... Carroll,s Through the Looking Glass, collaborators from the ... improved a 35-year-old ecology model to better understand ... years. , The new model, called a mean ... Effect," an evolutionary hypothesis introduced by Lee Van ... must constantly increase their fitness (or ability to ...
(Date:7/30/2014)... that David L. Kaplan, Ph.D., will head the brand-new, ... as editor-in-chief. With the first issue slated for publication ... research in the rapidly burgeoning field of biomaterials, the ... with living or biological systems. , "This new journal ... the field of biomaterials over the past decade and ...
Breaking Biology News(10 mins):Engineering a protein to prevent brain damage from toxic agents 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... Children,s National Medical Center have discovered that ... are significantly more likely to have low levels of ... This study supports recent research that suggests vitamin D ... keeping bones healthy. Vitamin D deficiency has been recently ...
... March 17 Orbel,s innovative Board Shield ... PCB shield. Visit the BLS section   ... variety of surface mount or through-hole configurations. Then click ... lets you enter shield dimensions, mounting style, and ...
... In the 1930s, soil used as ballast to weigh down ... red imported fire ant to the southern United States. Since ... Maryland and as far west as California, shorting out streetlights ... Plant pests like the fire ant cost the U.S. ...
Cached Biology News:Study: Low levels of vitamin D linked to higher rates of asthma in African-American kids 2Orbel Introduces the Board Shielding Wizard 2From international harbor to native habitat 2From international harbor to native habitat 3
(Date:7/31/2014)... -- Nearly 20,000 medical professionals and healthcare leaders gathered ... Lab Expo in Chicago from ... research and technology that will advance medicine and get ... Wednesday, July 30, more than 19,500 attendees had registered ... Expo, with more than 10,000 of these attendees coming ...
(Date:7/31/2014)... sound-processing part of the mouse brain in a way ... in view. Their imaging technique allows zooming in and ... it enabled the team to watch brain cells light ... which represent a step toward better understanding how our ... journal Neuron . , In the past, researchers ...
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... , July 31, 2014 Research ... "Global Genomics Market 2014-2018" report to their ... Genomics is the study of the genetic material ... be a strong basis for the discovery and development ... human diseases or health conditions. Genomics is supported by ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... Madison, Wis. - The University of Wisconsin System ... patents, but ranks lower in transferring that technology to commercial ... included nearly 500 universities worldwide and more than 200 in ... of Santa Monica, Calif. In terms of number and ...
... soil. He also knows how to build a viable ... his ideas about turning landscape data into packaged products ... everywhere," said Rooney, founder and president of Earth ... the growing power of digital communications, he explained, creates ...
... Wis. - Raghu Ramakrishnan wishes he had a crystal ... driver in business. , ,Ramakrishnan, a vice president and research ... next great driver is search, which he called "the cash ... his preference trumps his hunch, it is user-generated content (combined ...
Cached Biology Technology:UW among top biotech patent producers 2Global information firm reaches diverse markets 2Global information firm reaches diverse markets 3Global information firm reaches diverse markets 4Online communities may be next business market 2Online communities may be next business market 3
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
One-step, microplate or cuvet, colorimetric, detection range 0.78 ug/dL to 65 ug/dL Zn in serum, plasma, urine, saliva etc. Procedure: 10 min....
... Components: MBP Coated ... Assay Dilution Buffer, 5X, #20 Magnesium/ATP Cocktail, ... Buffer, 10X LumiGLO™ Chemiluminescen LumiGLO™ Chemiluminescen ... enzyme assay Quality Assurance: ...
Rabbit Serum New Zealand or California Origin...
Biology Products: