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Genes behind obesity mapped in large-scale study
Date:4/7/2013

etic structure and distribution of gene variants between extreme forms of obesity and milder forms.

"This knowledge is important because it increases the biological understanding of the origins of extreme obesity as well as milder forms of obesity. Our results suggest that extremely obese individuals have a greater number of gene variants that increase the risk of obesity, rather than completely different genes being involved. In the long term, our findings may lead to new ways of preventing and treating obesity, which is one of the greatest global public health problems of our age," says Erik Ingelsson.

The study is also important because it indicates that conclusions from genetic studies of the most extreme cases of a certain characteristic, such as extreme obesity, may be generalized to the rest of the population. This is important knowledge for the design of future studies.

The present study was carried out within the framework of the research consortium GIANT (Genetic Investigation of ANthropometrical Traits) which has gathered over one hundred partial studies and more than 300 co-authors. The study was coordinated by Erik Ingelsson, who is one of the leaders of the consortium, together with researchers from several leading research institutes in the United Kingdom and the United States.


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Contact: Erik Ingelsson
erik.ingelsson@medsci.uu.se
46-707-569-422
Uppsala University
Source:Eurekalert

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