Navigation Links
Genes behind obesity mapped in large-scale study
Date:4/7/2013

An international research team has identified seven new gene loci linked to obesity. Researchers were also able to show that the genetic mechanisms that cause extreme obesity are similar to those that cause milder forms of overweight and obesity.

A total of more than 260,000 people were included in the study of the links between genes and obesity, which will be published in the latest issue of Nature Genetics. The aim of the study was to identify new genes that increase the risk of obesity, but also to compare genetic factors that cause extreme obesity with those that are linked to rest of the BMI range.

"We know from experience that genetic factors are important for the emergence of both milder and more extreme forms of obesity, but how much overlap there is between genes that are involved in extreme obesity and normal or slightly elevated BMI has not been examined systematically previously," says Erik Ingelsson, Professor at the Department of Medical Sciences and Science for Life Laboratory, Uppsala University, who coordinated the study.

The researchers studied gene variants, or positions in the genetic code that differ between individuals. Many million such commonly occurring inherited differences are scattered throughout the genome. In the recently published study, researchers identified loci (regions of the genome) that are linked to obesity through examining the relationship between different body measurements and 2.8 million gene variants in 168,267 participants.

They then carried out a targeted follow-up of the 273 gene variants with the strongest link to various body measurements in another 109,703 people. Through this extensive gene mapping they were able to confirm the majority of the gene loci which were already linked to various body measurements, as well as identifying four new gene loci linked to height, and seven loci linked to overweight and obesity. They could also demonstrate a great overlap of gen
'/>"/>

Contact: Erik Ingelsson
erik.ingelsson@medsci.uu.se
46-707-569-422
Uppsala University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Finding genes for childhood obesity
2. New insights into how genes turn on and off
3. Appetite genes are key to better diets for poultry, study shows
4. Genes may be reason some kids are picky about food
5. Researchers create map of shortcuts between all human genes
6. Sleator lab identifies single point mutation in Listeria monocytogenes
7. March of Dimes awards $250,000 to researcher who identified heart disease genes
8. 2 new genes linked to amyotrophic lateral sclerosis and related disorders
9. Scientists find surprising new influence on cancer genes
10. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
11. Schizophrenia genes increase chance of IQ loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 According to a new ... Software, Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, ... Forecast to 2020", published by MarketsandMarkets, defines and segments ... various segments. The global PIAM Market is estimated to ... by 2019, at a CAGR of 14.9 % from ...
(Date:8/3/2015)... JOSE, Calif. , Aug. 3, 2015 ... of human interface solutions, today announced that members of ... community at the Pacific Crest Global Technology Leadership Forum ... Time. The conference will be held at the Sonnenalp ... The presentation may include forward-looking information. An ...
(Date:7/31/2015)... de 2015 La 10 th International Conference ... de BGI del 22 al 25 de octubre de 2015 en ... año, la conferencia celebra su décimo aniversario. Desde su inauguración ... de las reuniones anuales más influyentes del mundo en el ... dinámicas, entusiastas y mejores a nivel científico. ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... to know how plants grow, reproduce and communicate? Hundreds ... Berkeley and Cornell to McGill and the University of ... all things green: Plant Biology 2010. Media are welcome ... 2010 - Joint Annual Meetings of American Society of ...
... homespun advice, a team of researchers at Worcester Polytechnic ... that enable cranberry juice to fight off urinary tract ... the paper "Direct adhesion force measurements between E. ... cocktail," which was published on-line, ahead of print, by ...
... the amount of sodium chloride in food can lower the ... Klaus and colleagues come to in the current issue of ... 457-62). People whose intake of dietary sodium chloride is in ... cardiovascular morbidities and hypertension. This is particularly notable in view ...
Cached Biology News:Flowers do it, trees do it: Symposium on plant reproduction 2WPI research shows how cranberry juice fights bacteria at the molecular level 2WPI research shows how cranberry juice fights bacteria at the molecular level 3
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... ... 27, 2015 , ... Inc. Magazine released its annual list of the 5,000 ... in growth for the three years through 2014. Being named to the Inc. 5000 ... in the country. , “We are thrilled to make the Inc. 5000 list ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, a ... US laboratory is to open in Manhattan, Kansas in early October, 2015. The ... growth of research and development through collaboration with researchers from Kansas State University’s ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes Research ... University of Miami Miller School of Medicine, announced ... trial to test for the first time a ... completed.  This FDA approved Phase I/II study builds ... and is an important first step toward the ...
Breaking Biology Technology:Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4
... MADISON First, a full disclosure: Ive been hawking the concept ... a couple of years, so its no surprise I would think ... finding common ground. , ,Then again, its still something of ... dont have to be a student of Wisconsin history to know ...
... - There is both a new World Wide Web ... branding/marketing professionals would be wise to adapt to, according to ... conference, which is being held at Monona Terrace , ... era where technology has helped put the consumer in charge. ...
... When there was a monopoly phone service prior to the ... "give exclusivity in the territory and we will provide universal ... to a geographic subscriber base, the traditional phone companies ensured ... a fair price. There was one price across the board. ...
Cached Biology Technology:A (modern) Tale of Two Cities: Milwaukee and Madison inch together 2A (modern) Tale of Two Cities: Milwaukee and Madison inch together 3Marketers advised to engage "search economy" 2Marketers advised to engage "search economy" 3Does redefining universal service help bridge the digital divide? 2Does redefining universal service help bridge the digital divide? 3Does redefining universal service help bridge the digital divide? 4Does redefining universal service help bridge the digital divide? 5
... An N-nitroso-containing diabetogenic compound that acts ... pancreatic islets. An antibiotic effective against ... DNA strand breaks in pancreatic islet ... in H 2 O. RTECS LZ5775000, ...
Mouse monoclonal antibody to CDC2L5 - cell division cycle 2-like 5 (cholinesterase-related cell division controller)...
... The pACHLT-A-BFP Baculovirus Transfer Vector is a derivative ... the gene for blue fluorescent protein (BFP), followed ... site (MCS).,Foreign genes are expressed as BFP-6xHis fusion ... restriction enzyme,sites (EcoR I, Stu I, Sac I, ...
... of Br-dUTP results in a stronger signal ... fluorescein-labeled anti-BrdU antibody. Propidium iodide/RNase A ... counterstain the total DNA. Features and Benefits: ... detection than found by using biotin- or ...
Biology Products: