Navigation Links
Genealogy and biogeography meet personalized medicine
Date:4/29/2014

Biogeographical data is useful in screening for disease risk and drug sensitivity associated with certain ethnic groups. A team of researchers, including an investigator from Children's Hospital Los Angeles, has developed a tool to accurately identify the biogeography of worldwide individuals. Previous tools were accurate in identifying place of origin within homogeneous European populations but highly inaccurate for places with significant immigration, such as the U.S.

Tatiana Tatarinova, PhD, of The Saban Research Institute of Children's Hospital Los Angeles, Eran Elhaik, PhD, of the University of Sheffield and colleagues developed an admixture-based Geographic Population Structure (GPS) tool that uses genetic distribution and geographical distance to determine place of origin, specifically the country, or in some cases, the village of origin. Their study will be published in the journal Nature Communications on April 29, 2014.

"We were surprised by the simplicity and precision of this method," said Tatarinova, who is also an associate professor of Research Pediatrics at the Keck School of Medicine of the University of Southern California. "People in a given geographical area are more likely to have similar genetics. When they also have genetic traits typically found in other, distant regions, the geographical origin of those traits is generally the closest location where those traits can be found."

Using a database of worldwide populations, the investigators developed a dataset of reference populations that are genetically diverse and have been geographically localized for centuries. With the GPS tool, the investigators were able to take unknown samples, identify the proportions of admixture--meaning, genetic characteristics specific to certain ethnic groups that were combined because of events like migration or invasion--and then calculate the distance to the nearest known population that shares the same admixtu
'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Advances in personalized medicine for lung cancer
2. Chromosomal translocations point the way toward personalized cancer care
3. Creating a future of personalized medicine: U-M forms joint venture for DNA diagnostics
4. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
5. Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine
6. Scanning innovation can improve personalized medicine
7. Study advances use of stem cells in personalized medicine
8. BodyMedia & FitOrbit Up the Ante in Personalized Weight Loss
9. Report from the front lines of personalized reproductive medicine revolution
10. Personalized medicine eliminates need for drug in 2 children
11. Personalized health care will revolutionize 21st century medicine, says NJIT professor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genealogy and biogeography meet personalized medicine
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... (HBI) at the University of Calgary,s Faculty of Medicine ... drive in rats. This new discovery, published online this ... into why stress is thought to be one of ... produces neurotransmitters (chemicals responsible for how cells communicate in ...
... DC (August 12, 2011) Children with only mildly ... in puberty, and heart problems, according to a study ... Journal of the American Society Nephrology (JASN). Therapies ... kidney disease in children. Heart disease causes almost ...
... have changed the distribution patterns of Atlantic mackerel ( ... from Cape Hatteras to Newfoundland, shifting the stock northeastward ... on a seasonal basis to feed and spawn, and ... could have significant implications for U.S. commercial and recreational ...
Cached Biology News:Scientists highlight link between stress and appetite 2Scientists link shifting Atlantic mackerel distribution to environmental factors, changing climate 2Scientists link shifting Atlantic mackerel distribution to environmental factors, changing climate 3
(Date:5/21/2015)... 2015 Veolia’s environmental monitoring technology ... American distribution agreement with VWR to distribute TECTA™ ... more than 160 years of experience, VWR, a ... laboratory and production facilities, has cultivated a value ... services to enable science. Endetec’s TECTA™ B16, ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 This ... history, especially for lawns. US Patented Pearl’s Premium ... for lawns around the country that are coming out ... that addresses a number of major global concerns related ... the “non-grass” grass – the alternative to the standard, ...
(Date:5/20/2015)... 20, 2015  Health eCareers, the healthcare industry,s ... with job seekers looking for the flexibility of ... mobile and online tool dedicated exclusively to temporary ... SHIFT enables employers to quickly find and ... per diem and other temporary positions, eliminating the ...
(Date:5/20/2015)... 20, 2015  Cypher Genomics, Inc., a leading ... Celgene Corporation to apply Cypher,s Coral TM ... with patient response to innovative medicines. The information ... accelerate patient access to the right medicine at ... and development and potentially inform new companion diagnostics.  ...
Breaking Biology Technology:Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2
... 25 SuperGen Inc.,(Nasdaq: SUPG ), a ... commercialization of therapies for solid tumors and,hematological malignancies, ... quarter and fiscal year-end financial results on Monday, ... the Company,s financial,results, and provide financial guidance for ...
... (Nasdaq: IDIX ), a biopharmaceutical company engaged,in the ... human viral,and other infectious diseases, announced today that three ... Meeting of the European,Association for the Study of the ... - 27, 2008. Full abstracts can now be viewed ...
... Feb. 25 The International,Confocal Microscopy Working ... students, has been formed as a means ... reflective confocal microscopy (RCM) in,patient care., ... new members worldwide.,Dermatologists, dermascopists, dermatopathologists, medical students ...
Cached Biology Technology:SuperGen to Announce 2007 Fourth Quarter and Fiscal Year-End Financial Results March 3, 2008 2Idenix Announces Data Presentations at the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) 2Idenix Announces Data Presentations at the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) 3International Confocal Microscopy Working Group Established to Advance Practice of Reflective Confocal Microscopy 2
UltraMount is formulated for coverslipping sections stained with alcohol soluble chromogens, such as Fast-Red or AEC. No heating is required prior to use. Coverslips may be removed by soaking in wate...
Agarose, Biotechnology grade, 500g...
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
... The c-Jun proto-oncogene was first identified as the ... oncogene. Jun B and Jun D have been ... their C-terminal regions, which are involved in dimerization ... are involved in transcriptional activation, diverge. ...
Biology Products: