Navigation Links
Gene with probable role in human susceptibility to pulmonary tuberculosis identified
Date:10/9/2008

A new gene that may confer susceptibility to pulmonary tuberculosis has been identified by Genome Institute of Singapore (GIS) researchers and their collaborators in The Netherlands, Indonesia, United Kingdom, and the Russian Federation.

In the current j PLoS Genetics, the scientists report that the gene, named Toll-like receptor 8 (TLR8), which had been previously shown to recognize some factors from viruses such as the human immunodeficiency virus (HIV), also has a probable role in human susceptibility to Mycobacterium tuberculosis infections.

The study also found that males are more susceptible than females.

"We are really excited about this discovery as it is the first time TLR8 has been implicated in bacteria infections," said Dr. Sonia Davila, GIS Research Scientist and first author of the article.

"Our analysis of the results from cohort studies in Indonesia and Russia suggested that susceptibility was attributed to genetic variants of TLR8, which is located at the X chromosome.

"Males carrying only one copy of the gene could have a higher chance of suffering from the disease," Dr. Davia added. "These findings open up a whole new area of research and we hope that it will increase our understanding of the disease process of pulmonary tuberculosis."

GIS Senior Group Leader and Associate Director of Infectious Diseases, Dr. Martin Hibberd noted, "This project is a great example of international teams coming together to solve a difficult problem, with groups from Indonesia, Singapore, UK, Russia and the Netherlands playing important roles. We hope that this work can initiate further research that will make a difference to people suffering from TB".

"The team from the Genome Institute led by Drs. Davila, Seielstad and Hibberd has made an important new discovery of an alternative cellular receptor for one of the world's most important infectious agents, M. tuberculosis, the causative agent of TB," said Dr. Paul MacAry, Assistant Professor at National University of Singapore Graduate School for Integrative Sciences and Engineering.

"The identification of a role for TLR8 in TB infection has the potential to open up new areas of exploration in TB host/pathogen interactions and provide researchers and clinician scientists with novel targets for therapeutic intervention," Dr. MacAry added. "This is extremely important given the emergence of multi-drug resistant strains of M.tuberculosis that are refractive to current treatment regimes."

Pulmonary tuberculosis is a contagious lung disease caused by a bacterium known as Mycobacterium tuberculosis (M. tuberculosis). Although a third of the world population is infected with M. tuberculosis, only 5 to 10% of them will ever develop tuberculosis, giving rise to a proposition that there may be a difference in genetic variants within the genes involved in host immune response.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. TheVisualMD.com launches new animated 3-D views of human body in action
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Study: Bird diversity lessens human exposure to West Nile Virus
4. Research shows Brazilian acai berry antioxidants absorbed by human body
5. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
6. During exercise, the human brain shifts into high gear on alternative energy
7. Scientists identify novel inhibitor of human microRNA
8. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
9. Longevity, cancer and diet connected: New research in worms could apply to humans
10. UNC scientists turn human skin cells into insulin-producing cells
11. Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/20/2017)... March 20, 2017 PMD Healthcare announces the ... and Wellness Management System (WMS), a remote, real-time lung ... 2010, PMD Healthcare is a Medical Device, Digital Health, ... dedicated to creating innovative solutions that empower people to ... intent focus, PMD developed the first ever personal spirometer, ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... ... LabRoots , the leading provider of scientific trending news and interactive ... a new textbook scholarship, the second scholarship in the LabRoots program. , This ... pursuing a degree in one of the life sciences. The scholarship will provide one ...
(Date:5/24/2017)... ... May 24, 2017 , ... Patient Monitoring ... with Wi-Fi connectivity to reduce the amount of wiring in a healthcare facility ... compact mobile devices including infusion pumps, heart and hypertension monitoring, glucose monitoring, and ...
(Date:5/23/2017)... ... May 23, 2017 , ... Genedata, a leading provider of ... occasion with a strong presence at Bio-IT World Conference & Expo 2017 in ... invitation to all attendees to view posters on the entire range of ...
(Date:5/23/2017)... ... 23, 2017 , ... Kathy Goin is joining myClin ... brings years of expertise in establishing and leading clinical operations at Sponsors including ... occupational therapist, through a variety of leadership roles in Clinical Operations, to her ...
Breaking Biology Technology: