Navigation Links
Gene with probable role in human susceptibility to pulmonary tuberculosis identified
Date:10/9/2008

A new gene that may confer susceptibility to pulmonary tuberculosis has been identified by Genome Institute of Singapore (GIS) researchers and their collaborators in The Netherlands, Indonesia, United Kingdom, and the Russian Federation.

In the current j PLoS Genetics, the scientists report that the gene, named Toll-like receptor 8 (TLR8), which had been previously shown to recognize some factors from viruses such as the human immunodeficiency virus (HIV), also has a probable role in human susceptibility to Mycobacterium tuberculosis infections.

The study also found that males are more susceptible than females.

"We are really excited about this discovery as it is the first time TLR8 has been implicated in bacteria infections," said Dr. Sonia Davila, GIS Research Scientist and first author of the article.

"Our analysis of the results from cohort studies in Indonesia and Russia suggested that susceptibility was attributed to genetic variants of TLR8, which is located at the X chromosome.

"Males carrying only one copy of the gene could have a higher chance of suffering from the disease," Dr. Davia added. "These findings open up a whole new area of research and we hope that it will increase our understanding of the disease process of pulmonary tuberculosis."

GIS Senior Group Leader and Associate Director of Infectious Diseases, Dr. Martin Hibberd noted, "This project is a great example of international teams coming together to solve a difficult problem, with groups from Indonesia, Singapore, UK, Russia and the Netherlands playing important roles. We hope that this work can initiate further research that will make a difference to people suffering from TB".

"The team from the Genome Institute led by Drs. Davila, Seielstad and Hibberd has made an important new discovery of an alternative cellular receptor for one of the world's most important infectious agents, M. tuberculosis, th
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. TheVisualMD.com launches new animated 3-D views of human body in action
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Study: Bird diversity lessens human exposure to West Nile Virus
4. Research shows Brazilian acai berry antioxidants absorbed by human body
5. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
6. During exercise, the human brain shifts into high gear on alternative energy
7. Scientists identify novel inhibitor of human microRNA
8. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
9. Longevity, cancer and diet connected: New research in worms could apply to humans
10. UNC scientists turn human skin cells into insulin-producing cells
11. Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... is a vital source of energy for both plants ... its way into the cell could lead to the ... increase in the amount of fruits and vegetables farmers ... uncovered one of these "pathways" into the cell by ... a strand of spider silk. , To determine the ...
(Date:9/15/2014)... State University researchers have found "the most famous wheat ... be used to transfer valuable genes from ... for breeders to develop wheat varieties with the disease- ... of genetic tools that can reduce crop losses and ... controversy of Genetically Modified Organisms, or GMOs., "The real ...
(Date:9/15/2014)... strategic vision document, released today by the National ... long-term goals, objectives, and strategies for the program ... the next five years (2015-2020). In addition, ... to be funded in 2015, will include exploratory ... , The $500 million, 30-year program to ...
Breaking Biology News(10 mins):X-rays unlock a protein's SWEET side 2X-rays unlock a protein's SWEET side 3WSU researchers find 'most famous wheat gene' 2NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4
... NEW YORK, April 5, 2010 Alpha cells in ... insulin-producing beta cells, advancing the prospect of regenerating beta cells ... come from a study at the University of Geneva, co-funded ... in the online edition of the scientific journal Nature ...
... always get what they want, to paraphrase the Rolling Stones, ... a study that will appear in the May issue of ... both the broad sweep of evolutionary changes in life on ... regional environmental shifts. And yet the amount of variability seen ...
... Commission has approved a $1,127,873 award to Yellow ... of Cincinnati for their "Advanced Modified Carbon Nanotube-Based ... Research Professor William Heineman, in the McMicken College ... officially part of the million-dollar team. ...
Cached Biology News:Researchers show some cells in pancreas can spontaneously change into insulin-producing cells 2Researchers show some cells in pancreas can spontaneously change into insulin-producing cells 3Ecologists receive mixed news from fossil record 2Ohio Third Frontier awards million-dollar grant to YSI-University of Cincinnati team 2Ohio Third Frontier awards million-dollar grant to YSI-University of Cincinnati team 3
(Date:9/15/2014)... SYDNEY , Sept. 15, 2014 ... focused on revolutionizing the treatment of cancer through ... cancer cells, announced that, together with the Asbestos ... 2014 Cancer Institute New South Wales (NSW) Premier,s ... other four recipients are the hospitals that will ...
(Date:9/15/2014)... from North Carolina State University have developed a technique ... applying very low voltages, opening the door to a ... technologies. The technique hinges on the fact that the ... deposited or removed acts as a surfactant, lowering ... fluid. , The researchers used a liquid metal alloy ...
(Date:9/15/2014)... fibers made of carbon nanotubes is neat, but Rice University ... carbon nanotubes in new fibers created at Rice line up ... by chemist Angel Mart and his colleagues. , The tricky ... month in the journal ACS Nano , is keeping ... a fiber. , Left to their own devices, carbon nanotubes ...
(Date:9/15/2014)... MORRISVILLE, NC (PRWEB) September 15, 2014 ... newly developed deep imaging OCT system for the optical ... , The EnvisuTM S4410 SDOCT for Contact ... measurements for standard and high complexity contact lens, IOL ... allows imaging of a complete contact lens immersed in ...
Breaking Biology Technology:EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3Researchers control surface tension to manipulate liquid metals 2Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2
... STAAR Surgical Company (Nasdaq: STAA ), a ... products, today announced that it has received CE Mark ... use in minimally invasive cataract surgical procedures. The ... intraocular (IOL) KS-X lens delivery system in the European ...
... ... Matrix Genomics, Inc. have identified a concise genetic signature found among a third of Parkinson,s ... is found in the LRRK2 gene located on chromosome 12. The work was led by ... ...
... Bioscience International, a leader in enabling and accelerating the ... China, today announced a strategic drug co-development partnership with ... range of therapeutic areas and represents one of the ... biotech company and a Chinese university. , , ...
Cached Biology Technology:STAAR Surgical Receives CE Mark Approval for KS-X Preloaded Hydrophobic Acrylic Lens Injector System 2STAAR Surgical Receives CE Mark Approval for KS-X Preloaded Hydrophobic Acrylic Lens Injector System 3STAAR Surgical Receives CE Mark Approval for KS-X Preloaded Hydrophobic Acrylic Lens Injector System 4Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease 2Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease 3HUYA Bioscience Announces Strategic Collaboration With the Shenyang Pharmaceutical University 2HUYA Bioscience Announces Strategic Collaboration With the Shenyang Pharmaceutical University 3
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Applications: Western blotting Stability: Room temperature, indefinitely ...
... Rabbit Antibody to ARG. Vasopressin ... vasopression peptide. Cells are found in ... fibers are found throughout the hypothalmus ... perfused tissue. Immunogen: ...
CircuLex Anti-Human S100P Polyclonal Antibody Research Focus: proliferation Storage: -20C Shipping Temperature: 4C...
Biology Products: