Navigation Links
Gene with probable role in human susceptibility to pulmonary tuberculosis identified
Date:10/9/2008

A new gene that may confer susceptibility to pulmonary tuberculosis has been identified by Genome Institute of Singapore (GIS) researchers and their collaborators in The Netherlands, Indonesia, United Kingdom, and the Russian Federation.

In the current j PLoS Genetics, the scientists report that the gene, named Toll-like receptor 8 (TLR8), which had been previously shown to recognize some factors from viruses such as the human immunodeficiency virus (HIV), also has a probable role in human susceptibility to Mycobacterium tuberculosis infections.

The study also found that males are more susceptible than females.

"We are really excited about this discovery as it is the first time TLR8 has been implicated in bacteria infections," said Dr. Sonia Davila, GIS Research Scientist and first author of the article.

"Our analysis of the results from cohort studies in Indonesia and Russia suggested that susceptibility was attributed to genetic variants of TLR8, which is located at the X chromosome.

"Males carrying only one copy of the gene could have a higher chance of suffering from the disease," Dr. Davia added. "These findings open up a whole new area of research and we hope that it will increase our understanding of the disease process of pulmonary tuberculosis."

GIS Senior Group Leader and Associate Director of Infectious Diseases, Dr. Martin Hibberd noted, "This project is a great example of international teams coming together to solve a difficult problem, with groups from Indonesia, Singapore, UK, Russia and the Netherlands playing important roles. We hope that this work can initiate further research that will make a difference to people suffering from TB".

"The team from the Genome Institute led by Drs. Davila, Seielstad and Hibberd has made an important new discovery of an alternative cellular receptor for one of the world's most important infectious agents, M. tuberculosis, the causative agent of TB," said Dr. Paul MacAry, Assistant Professor at National University of Singapore Graduate School for Integrative Sciences and Engineering.

"The identification of a role for TLR8 in TB infection has the potential to open up new areas of exploration in TB host/pathogen interactions and provide researchers and clinician scientists with novel targets for therapeutic intervention," Dr. MacAry added. "This is extremely important given the emergence of multi-drug resistant strains of M.tuberculosis that are refractive to current treatment regimes."

Pulmonary tuberculosis is a contagious lung disease caused by a bacterium known as Mycobacterium tuberculosis (M. tuberculosis). Although a third of the world population is infected with M. tuberculosis, only 5 to 10% of them will ever develop tuberculosis, giving rise to a proposition that there may be a difference in genetic variants within the genes involved in host immune response.


'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. TheVisualMD.com launches new animated 3-D views of human body in action
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Study: Bird diversity lessens human exposure to West Nile Virus
4. Research shows Brazilian acai berry antioxidants absorbed by human body
5. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
6. During exercise, the human brain shifts into high gear on alternative energy
7. Scientists identify novel inhibitor of human microRNA
8. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
9. Longevity, cancer and diet connected: New research in worms could apply to humans
10. UNC scientists turn human skin cells into insulin-producing cells
11. Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it ... Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/10/2017)... ... 10, 2017 , ... The Pittcon Program Committee is pleased ... scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each ... leading conference and exposition for laboratory science, which will be held February 26-March ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation President ... and Astronomy, has been selected for membership in ARCS Alumni Hall of Fame ... Prize in Fundamental physics for the discovery of the accelerating expansion of the universe, ...
Breaking Biology Technology: