Navigation Links
Gene variations that alter key enzyme linked to prostate cancer
Date:10/1/2010

Researchers at the National Institutes of Health have found that variations in a gene for an enzyme involved in cell energy metabolism appear to increase the risk for prostate cancer.

The genetic variations all impair the enzyme phosphodiesterase 11A (PDE11A), which helps regulate a cell's responses to hormones and other signals. Previous studies by NIH researchers have linked genetic variations that inactivate PDE11A with increased susceptibility to testicular cancer and adrenal tumors

The researchers found that a group of men with prostate cancer were nearly four times more likely to have variations affecting the activity of PDE11A than did men who did not have prostate cancer. In 2010, it is estimated that there will be 217,730 new cases of prostate cancer, and 32,050 deaths (http://www.cancer.gov/cancertopics/types/prostate).

"Our study indicates that PDE11A one day may have a place in genetic screening for predisposition to prostate cancer," said the senior author of the study, Constantine Stratakis, M.D., D.Sc., acting director of the Intramural Research program at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Dr. Stratakis's research team included colleagues at the NICHD, first author Fabio Rueda Faucz and colleagues from the Pontifical Catholic University of Parana, Brazil; the Cochin Institute in Paris; and A.C. Camargo Hospital in Sao Paulo. The investigators also received support from the Parana State Secretariat of Science, Technology and Higher Education.

The findings were published online in the Journal of Clinical Endocrinology and Metabolism.

The researchers examined tissue from 50 men with prostate cancer and 287 men who did not have prostate cancer. The researchers analyzed the DNA of the men and found 8 variations in the PDE11A gene that decreased the production
'/>"/>

Contact: Robert Bock
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of MN study shows link between gene variations and cancer survival
2. Scientists uncover new genetic variations linked to psoriasis
3. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
4. Study finds variations in 1 gene may be associated with endurance running
5. Variations on the genetic theme
6. Rare and common genetic variations responsible for high triglyceride levels in blood
7. Alternative to burning: environmentally sound disposal for wood chips
8. During exercise, the human brain shifts into high gear on alternative energy
9. Earthworm activity can alter forests carbon-carrying capabilities
10. Social interactions can alter gene expression in the brain, and vice versa
11. Turtles alter nesting dates due to temperature change says ISU researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Service Provider Binary Biometrics is pleased to welcome Kevin Morris ... improve its mobile service capabilities and add more daily appointments, which will allow ... several new cities such as, but not limited to, Daytona Beach ... Deltona , Edgewater , Holly Hill ... , Oak Hill , Orange City ...
(Date:7/31/2014)... In the United States, natural-gas production from shale ... since 2007. Yet scientists still do not fully ... according to a report in the journal ... As gas extraction continues to vastly outpace scientific ... various organizations and institutions, including Princeton University, concluded ...
(Date:7/31/2014)... bigeye tuna movements in the northwestern Atlantic Ocean led ... Center at the University of Massachusetts Amherst, found among ... range with pronounced north-south movements from Georges Bank to ... off Cape Hatteras southwest of Bermuda for foraging. , ... study one of the most important commercial tuna species ...
Breaking Biology News(10 mins):Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3
... the genome ?those that don't code for proteins ... regulate gene activity. Among those elements are microRNAs, ... expression. , Increasing evidence indicates a role for ... from Children's Hospital Boston now demonstrate that one ...
... rainforest puts on its biggest growth spurt during the dry ... , "Most of the vegetation around the world follows a ... the rainy season and then during the dry season, leaves ... support plant growth," said lead researcher Alfredo R. Huete of ...
... the use of letrozole, an easy-to-use and inexpensive ... be unfounded, according to a major study co–authored ... Reproductive Endocrinology and Infertility, McGill University Health Centre ... the Jewish General Hospital, and Professor of Obstetrics ...
Cached Biology News:Tiny RNA molecules fine-tune the brain's synapses 2Amazon rainforest greens up in the dry season 2Amazon rainforest greens up in the dry season 3Fertility drugs given 'all-clear' in new study 2
(Date:8/1/2014)... ON (PRWEB) August 01, 2014 ... has led to a better understanding embryonic development. ... and reorganize into structurally and functionally distinct tissues ... physical defects. Prof. Todd McDevitt, Melissa Kinney, ... biophysical signals interact with biochemical cues to control ...
(Date:7/31/2014)... July 31, 2014 Today BioSpace , the leading life ... map campaign spotlighting the life sciences community in Illinois ... Kansas , Michigan , Minnesota ... Ohio and Wisconsin . ... percent of all job postings on BioSpace originating in this region in ...
(Date:7/31/2014)... (1912-1954), is famous for a number of breakthroughs, which ... he published a paper, which laid the foundation of ... computer algorithm. He next played a pivotal role in ... the German military codes, enabling the Allies to defeat ... late 1940,s he turned his attention to artificial intelligence ...
(Date:7/31/2014)... University Bloomington have described the self-assembly of large, ... potential value for the field of organic electronic ... , Their paper, "Anion-Induced Dimerization of 5-fold Symmetric ... Crystals," has been published online by Chemical ... of Chemistry. It is the first collaboration by ...
Breaking Biology Technology:Study Links Biomechanics and Gene Expression in Stem Cells 2Midwest Biotech Leaders Featured On BioSpace Map 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3
... expanded access to choice, quality and cost-efficiency for patients ... Fla., June 24 Galichia Heart Hospital and Mobile ... to host MSI-coordinated, highly specialized, urologic surgical teams at ... Galichia,s capabilities as a center of excellence for selected ...
... 24 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... company focused on endocrine therapy and oncology, announced ... registered direct offering of US$10 million of units ... warrants to certain institutional investors. AEterna Zentaris received ...
... and diagnostics, including new technologies, enhanced biotech and drug developments, ... the center of Cleveland Clinic,s 7th Annual Medical Innovation Summit, ... more than 900 leaders from throughout the healthcare industry to ... and gain actionable insights. , , This year,s ...
Cached Biology Technology:Galichia Heart Hospital Partners with Mobile Surgery International to Develop Wichita-based Center of Excellence with Global Convenience(TM) 2Galichia Heart Hospital Partners with Mobile Surgery International to Develop Wichita-based Center of Excellence with Global Convenience(TM) 3AEterna Zentaris Receives US$10 Million from Institutional Investors 2AEterna Zentaris Receives US$10 Million from Institutional Investors 32009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 22009 Medical Innovation Summit at Cleveland Clinic to Highlight the Latest Developments in Cancer Care 3
... design in ice/water bath This CLS ... created to easily match Cornings product ... please order under the old Sigma-Aldrich ... for assistance. ID clarifier: rack and ...
... The Yeast Oligo Microarray Kit (V2), ... to simultaneously characterize expression of many ... gene activity during important biological processes. ... representing 6,256 known ORFs from the ...
... Oligo Microarray Kit (V2), 22K is useful for ... response. Each microarray contains content derived from the ... Genomic Research (TIGR) and represents 21,500 genes. ... 1 x 3? glass slides each containing an ...
... LCMSsolution software offers an intuitive, ... instrument control, diverse data handling, ... requirements. Comprehensive functions include data ... data management in both standalone ...
Biology Products: