Navigation Links
Gene variation predicts rate of age-related decline in mental performance, Stanford study
Date:10/25/2011

ore his first visit. Each annual visit consisted of morning and afternoon 75-minute "flights," during which pilots confronted flight scenarios with emergency situations, such as engine malfunctions and/or incoming air traffic. Resulting test scores pooled several variables, such as pilots' reaction times and their virtual planes' deviations from ideal altitudes, directions and speed. A pilot's score represented the overall skill with which he executed air-traffic control commands, avoided airborne traffic, detected engine emergencies and approached landing strips.

Blood and saliva samples collected on the pilots' first visits allowed the Stanford investigators to genotype all 144 pilots, of whom 55 (38.2 percent) turned out to have at least one copy of a BDNF gene that contained the "met" variant. In their analysis, the researchers also corrected for pilots' degree of experience and the presence of certain other confounding genetic influences.

Inevitably, performance dropped in both groups. But the rate of decline in the "met" group was much steeper.

"We saw a doubling of the rate of decline in performance on the exam among met carriers during the first two years of follow-up," said Salehi.

About one-third of the pilots also underwent at least one round of magnetic resonance imaging over the course of a few years, allowing the scientists to measure the size of their hippocampi. "Although we found no significant correlation between age and hippocampal size in the non-met carriers, we did detect a significant inverse relationship between age and hippocampal size in the met carriers," Salehi said.

Salehi cautioned that the research covered only two years and that the findings need to be confirmed by following participants over a multiyear period. This is now being done, he added.

No known drugs exist that mimic BDNF's action in the brain, but there is one well-established way to get around that: Stay active. "The on
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. UCLA Engineering researchers help develop complete map of mouse genetic variation
2. BGI develops new strategy to uncover structural variations of human genomes
3. 2 genetic variations predict second cancers after radiation for children with Hodgkin lymphoma
4. Tiny variation in 1 gene may have led to crucial changes in human brain
5. Climbers leave rare plants genetic variation on the rocks
6. Arctic climate variation under ancient greenhouse conditions
7. DNA sequence variations linked to electrical signal conduction in the heart
8. Shifting forms: Penn study shows how variations of same protein affect immune response
9. Gene variations that alter key enzyme linked to prostate cancer
10. Third generation map of human genetic variation published
11. UCLA study identifies genetic variation linked to lupus in Asian men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... of Yale researchers will lead a five-year, $3 million ... events is affecting the transport of dissolved organic matter ... say could alter the chemical composition and water quality ... funding from the National Science Foundation,s MacroSystems Biology program, ... the watershed, which begins in Canada and runs through ...
(Date:4/22/2014)... 22, 2014) Biotechnology scientists must be aware of ... and licensing guidelines, according to a new paper from ... in the current issue of the journal Regenerative ... 2013 U.S. Supreme Court ruling in the case Association ... occurring genes are unpatentable. The court case and rulings ...
(Date:4/22/2014)... University of Massachusetts Amherst and the Instituto Nacional de ... they have discovered a new genus and species of ... in the Amazonia State of Brazil. , Professor Cristina ... Jos Antnio Alves-Gomes of INPA, describe the new bluntnose ... Proceedings of the Natural Sciences of Philadelphia . ...
Breaking Biology News(10 mins):Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3New electric fish genus and species discovered in Brazil's Rio Negro 2
... a $3 million five-year contract to Biomark Inc., of ... equipment to conduct on-going fish studies throughout the 17 ... endangered fish recovery programs. "This contract provides ... behavior that we rely upon to inform our river ...
... at the recent United Nations meeting emphasized nutrition as ... of State Hillary Clinton said a key focus is ... of Missouri nutrition experts say getting back to basics ... families and communities in many ways. As ...
... University,s Courant Institute of Mathematical Sciences, was today named ... highest honor bestowed by the United States government on ... of this year,s National Medal of Science will receive ... year. Varadhan, who has been recognized for his ...
Cached Biology News:Contract awarded for equipment to support on-going fish studies in the West 2Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say 2NYU mathematician Varadhan named recipient of National Medal of Science 2
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... age rests on our ability to control how electric ... circuitry. Doing so requires particular precision, for applications ranging ... task falls to semiconductors. Now, a research team ... Applied Science and Arts and Sciences has shown how ...
... (Nasdaq: SGMO ) today announced the pricing of ... common stock at a price to the public of $7.70 ... or around Wednesday, April 13, 2011, subject to customary closing ... this offering and Sangamo has granted the underwriter a thirty ...
... Inc. (Nasdaq: SGMO ) announced today that it ... pursuant to an effective shelf registration statement in an underwritten ... in this offering and Sangamo will grant the underwriter a ... shares. The securities described above are being ...
Cached Biology Technology:Penn research advances understanding of lead selenide nanowires 2Penn research advances understanding of lead selenide nanowires 3Sangamo Announces Pricing of Public Offering of Common Stock 2Sangamo Announces Pricing of Public Offering of Common Stock 3Sangamo Announces Public Offering of Common Stock 2Sangamo Announces Public Offering of Common Stock 3
Mouse monoclonal [H4B4] to LAMP2 - Lysosome Marker (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 3920 SwissProtID: P13473...
... Nikon's NIS-Elements revolutionizes imaging software for ... intelligence to microscopes, cameras, components and ... and achiving tools. Its intuitive interface ... acquisition times while providing powerful features ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
Vented Caps for 75 cm2 Flasks...
Biology Products: