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Gene variation may elevate risk of liver tumor in patients with cirrhosis
Date:1/1/2008

in the MGH group, it was noted that the G allele was more common among Asian patients; and it is well known that more than half the cases of HCC worldwide occur in China.

We now need to prospectively study EGF levels in cirrhotic patients, to see if elevated levels will correlate with a greater risk of developing HCC, and look at factors such as diet, drugs or ethnicity that may modulate EGF levels, Tanabe says. I think this is a terrific opportunity to see if targeting a specific pathway will prevent HCC in this group of patients, who are at risk for liver cancer because of their cirrhosis. Tanabe is an associate professor of Surgery at Harvard Medical School.


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Contact: Stacy Neale
sneale@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

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