Navigation Links
Gene variation may elevate risk of liver tumor in patients with cirrhosis
Date:1/1/2008

e presence of the nucleotide guanine (G) instead of the more common adenine (A) in a particular location which has been shown to increase EGF secretion in blood cells and raise the risk for malignant melanoma. Individuals inherit one copy of the gene from each parent and therefore have this gene with either two copies of A (A/A), two copies of G (G/G), or one copy of each (A/G). Genetic analysis of liver tumor cell lines showed that messenger RNA transcribed from DNA strands with the G allele was more stable that that transcribed from the A version, which could explain why cells with two G copies tend to secrete higher levels of EGF.

The researchers then studied tissue samples from all patients in the MGH Cancer Center Tumor Bank who had cirrhosis. Among the 207 patients with cirrhosis, most of whom were infected with the hepatitis C virus, 59 also had HCC. Patients with at least one copy of the G nucleotide had a significantly higher risk of developing HCC than did A/A patients ranging from a more than twofold increase for those with one G to an over fourfold increase for those with two G alleles. In all three genotypes, tissue analysis showed that EGF levels were highest in the G/G patients, as was activation of the EGFR receptor. In addition, blood levels of EGF were highest in those with two copies of the G allele.

To confirm these finding in a different patient population, the MGH team worked with colleagues from the Paul Brousse Hospital in Paris. Samples from this group, all of whom had alcoholic cirrhosis, also showed that patients with the G/G version of the EGF gene had a significantly greater risk of developing the liver tumor than did the A/A patients, in this instance an almost threefold risk increase.

In both the MGH and French study groups, controlling for factors such as age and gender did not change the increased risk associated with the G allele. While both groups primarily consisted of Caucasian patients,
'/>"/>

Contact: Stacy Neale
sneale@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New book presents successful strategies for probing genetic variation
2. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
3. Copy number variation may stem from replication misstep
4. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
5. Elevated nitric oxide in blood is key to high altitude function for Tibetans
6. Elevated carbon dioxide changes soil microbe mix below plants
7. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
8. Clearance of hepatitis C viral infection after liver transplantation
9. Targeting nerve growth factor may cure liver cancer
10. Mountain pine beetle: Canadas new government delivers
11. Using green chemistry to deliver cutting-edge drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/23/2015)... Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, announces its biometric payment technology, ... on CNBC television starting March 30 th . ... in New York markets. ... are excited about our new ad campaign following the recent ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has ... Strategic Business Report" report to their offering. ... US$ Thousands. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... Cleveland -- The use of padded headgear and gloves ... the head, according to newly published research from Cleveland ... Clinic,s Lutheran Hospital, the researchers replicated hook punches to ... pendulum. The impacts were measured under five padding configurations: ...
... This release is available in German . ... a draft version of the genome from a small fragment ... southern Siberia. The DNA sequences showed that this individual came ... become known as Denisovans. Together with their sister group the ...
... are you really eating when you,re eating chicken? Do different ... twins have similar fingerprints? How does sleep affect your memory? ... from 33 local schools will answer these and other intriguing ... the University of California, Riverside, Feb. 7-9. The fair will ...
Cached Biology News:Padded headgear, boxing gloves may offer some protection for fighters 2Entire genome of extinct human decoded from fossil 2Fair to bring future scientists and engineers to UC Riverside 2
(Date:4/17/2015)... WI (PRWEB) April 17, 2015 ... sales and marketing support for the powerful Orthogonal ... the Chemical Genomics Center at the Lankenau Institute ... LCGC’s mission is to measurably improve successful drug ... HTS, by offering rare, drug-like libraries available nowhere ...
(Date:4/16/2015)... CA (PRWEB) April 16, 2015 Cytokinetics, ... to report first quarter results on Thursday, April 30, ... Cytokinetics’ senior management will host a conference call at ... results and the company’s outlook for the future. , ... be accessed from the homepage and in the Investor ...
(Date:4/16/2015)... April 16, 2015 Regis Technologies looks ... Association for Cancer Research (AACR) annual meeting. Regis will ... Center, starting Saturday, April 18, in Philadelphia and running ... to title of the oldest and largest organization focused ... and grants, and partners with survivors to promote awareness ...
(Date:4/16/2015)... recognition of World Hemophilia Day, Biogen  (NASDAQ: BIIB ... than 15 prominent landmarks red throughout the United ... Bridge and Prudential Tower, Chicago,s Wrigley ... Denver,s Coors Field . The ... coincide with hemophilia community events in a dozen locations across ...
Breaking Biology Technology:BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4
... Research Institute Introduce New Research Base and First ... DIEGO, Feb. 11 Leading global biopharmaceutical company, ... have opened a new and expanded, 38,000-square-foot facility ... be dedicated to further development of peptide research ...
... Chair the Board LA JOLLA, Calif., Feb. 11 ... the formation of a Medical Advisory Board to provide ... for the treatment of heart failure.The Medical Advisory Board ... and oversight of the planned CDP-1050 Phase 2 clinical ...
... Labs, Inc. (OTC Bulletin Board: GOVX), an Atlanta-based, ... diseases caused by HIV-1 (Human Immunodeficiency Virus) and ... Ph.D., Chief Executive Officer and President, presented a ... & Investor Conference 2009, held at the Waldorf-Astoria ...
Cached Biology Technology:Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 2Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 3Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 4Cordex Pharma Forms Heart Failure Medical Advisory Board 2Cordex Pharma Forms Heart Failure Medical Advisory Board 3Cordex Pharma Forms Heart Failure Medical Advisory Board 4Cordex Pharma Forms Heart Failure Medical Advisory Board 5GeoVax Update Provided at the BIO CEO & Investor Conference 2009 2GeoVax Update Provided at the BIO CEO & Investor Conference 2009 3GeoVax Update Provided at the BIO CEO & Investor Conference 2009 4GeoVax Update Provided at the BIO CEO & Investor Conference 2009 5
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
Mouse monoclonal [DAPK-55] to DAP Kinase 1 ( Abpromise for all tested applications). entrezGeneID: 1612 SwissProtID: P53355...
KOR-1 (C-20)...
Biology Products: