Navigation Links
Gene variants may predict who will benefit from breast cancer prevention drugs
Date:6/13/2013

going breast cancer preventive treatment take tamoxifen or raloxifene for five years. In rare cases, the drugs can cause dangerous side effects, including blood clots, strokes and endometrial cancer.

Many women never try the therapy because the chance of success seems small (about 50 women in the NSABP trials needed to be treated to prevent one case of breast cancer) compared to the perceived risk of side effects. More women might benefit from the potentially life-saving strategy if doctors could better predict whether the therapy was highly likely to work. That's what the current study begins to do.

The investigators leveraged data from past NSABP breast cancer prevention trials that involved a total of more than 33,000 high-risk womenthe largest sets of such data in the world. Women in the trials gave scientists permission to use their genomic and other information for research purposes.

The scientists analyzed the genomic data by focusing on more than 500,000 genetic markers called single nucleotide polymorphisms (SNPs). Each SNP represents a single variation in the DNA sequence at a particular location within the genome.

To determine whether any SNPs were associated with breast cancer risk, the researchers computationally searched for SNPs that occurred more commonly in women who developed breast cancer during the trial than in women who remained free of the disease. The analysis identified two such SNPsone in a gene called ZNF423 and the other near a gene called CTSO.

Neither ZNF423 nor CTSOnor any SNPs related to these geneshad previously been associated with breast cancer or response to the preventive drugs. The scientists' work revealed that women with the beneficial version of the two SNPs were 5.71 times less likely to develop breast cancer while taking preventive drugs than were women with neither advantageous SNP.

Using a variety of biochemical studies, the scientists learned that ZNF423 and CTSO ac
'/>"/>

Contact: Alisa Z Machalek
alisa.machalek@nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Common genetic variants identify autism risk in high risk siblings of children with ASD
2. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
3. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
4. Supplement use predicts folate status in Canadian women
5. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
6. University of Toronto biologists predict extinction for organisms with poor quality genes
7. Scientists develop new technique that could improve heart attack prediction
8. Striatal brain volume predicts Huntington disease onset
9. Discovery of mechanisms predicting response to new treatments in colon cancer
10. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
11. Researchers identify genetic markers to predict male fertility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014) A rare genetic disorder known as Jacobsen syndrome ... joint investigation by researchers at San Diego State University ... to suggesting better treatment options for people with Jacobsen ... genetic underpinnings of autism., Jacobsen syndrome affects approximately 1 ... Health. It occurs in a person when there is ...
(Date:9/17/2014)... first partial genome sequence of an ancient pig. Extracted ... of the Montsoriu Castle in Girona, the data obtained ... today,s Iberian pig. Researchers also discard the hypothesis that ... The study, published in Heredity , sheds new ... on that of the Iberian breed, considered to be ...
(Date:9/17/2014)... decline, grasses have returned to some once-denuded patches of ... those places seems healthy again, but a new study ... coastal protection remains diminished. , "We,ve got ... back," said ecologist Mark Bertness, professor of biology at ... journal Biological Conservation . "The metric of a ...
Breaking Biology News(10 mins):A link between Jacobsen syndrome and autism 2Iberian pig genome remains unchanged after 5 centuries 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... importance of the world,s natural assets is now firmly on ... showcasing the enormous economic value of forests, freshwater, soils and ... of their loss, was the conclusion of The Economics of ... leader, Pavan Sukhdev. "TEEB has documented not ...
... they have solved an interesting problem: how to get ... complete vegetable protein. What,s more, they,ve joined forces with ... snack they,ve developed into the hands of 1.2 million ... country has decidedly vegetarian tastes, the Indian people just ...
... 19, 2010In response to a study regarding fish oil ... of the Journal of the American Medical Association (JAMA), ... association for the dietary supplement industry, reminds pregnant and ... recommended amounts of docosahexaenoic acid (DHA) throughout pregnancy. This ...
Cached Biology News:TEEB report puts world's natural assets on the global political radar 2TEEB report puts world's natural assets on the global political radar 3TEEB report puts world's natural assets on the global political radar 4TEEB report puts world's natural assets on the global political radar 5TEEB report puts world's natural assets on the global political radar 6Illinois scientists promote soy by currying favor with Indian taste buds 2CRN responds to JAMA fish oil study 2CRN responds to JAMA fish oil study 3
(Date:9/17/2014)... 17, 2014 JH Technologies ... located in Irvine. JH Technologies, a leader in ... recently announced an expanded partnership with Leica Microsystems into ... and image analysis solutions will be featured at the ... The new showroom facility is located within the JH ...
(Date:9/17/2014)... , Sept. 17, 2014 Intarcia ... quantitative data from a study of the cost and ... the 50 th Annual Meeting of the European ... poster session today, Christian Frois , Ph.D., of ... a series of planned Intarcia-sponsored, retrospective studies to characterize ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... molecular diagnostics company pioneering the field of molecular cytology, ... chief operating officer. Mr. Hall joined Veracyte ... company,s commercial entry into endocrinology. Since 2012, he has ... well as managed care and billing functions. As chief ...
(Date:9/17/2014)... Escape Alert, LLC . filed international patents for ... owners if their pet has escaped and enable them to track ... the pet’s body. This is the first implantable microchip with ... around for many years, they are passive until read by scanners, ... pet’s location or alert the owner that the pet has escaped. ...
Breaking Biology Technology:JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3
... , CHICAGO, June 23 Advanced Life Sciences Holdings, ... second non-human primate study involving its novel, once-a-day, oral ... Restanza achieved a 100% survival rate against an inhaled ... the study that received 16 mg/kg once-a-day (the human ...
... , , , Additions to the Human ... over 6,100 antibodies powered by Atlas Antibodies , , ... ) today announced the release of over 2,300 antibody additions ... ( www.sigma.com/prestige ), bringing the total number of ...
... from human patients into fruit flies, we,ve created the ... disease," says Albena Jordanova. "Now we have the opportunity ... as to start looking for substances with therapeutic value." ... between VIB researchers working at the University of Antwerp ...
Cached Biology Technology:Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 2Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 3Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 2Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 3Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM) 4Fruit fly steps in to fight human disease 2
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
...
...
... Quansys Biosciences Q-Plex Array is a new ... human, mouse, and rat research. The Q-Plex ... ELISA-based test where 4 distinct capture antibodies ... a 96-well plate in a defined array. ...
Biology Products: