Navigation Links
Gene variants in autism linked to brain development
Date:3/1/2011

ols. The study team reinforced their findings using information from mouse models, showing that mice with abnormal motor and learning behaviors similar to human autistic behaviors were more likely to have CNVs in genes analogous to human autism genes.

"Because the gene alterations that we found influence brain development, our hope is that they may eventually provide clues to developing diagnostic tests as well as treatments for children with autism," said co-author and lead clinician Josephine Elia, M.D., a child psychiatrist at Children's Hospital.

Unlike changes to single bases in DNA, called single-nucleotide polymorphisms (SNPs or "snips"), CNVs are larger alterations in DNA structuremissing or repeated stretches of dozens or hundreds of bases in sequence. CNVs have been implicated in other neuropsychiatric disorders, such as schizophrenia, bipolar disorder and attention-deficit hyperactivity disorder (ADHD)the latter in a previous study by White and Elia.

In the current research, White and colleagues searched for CNVs in a discovery cohort of 631 children with autism, 1,162 parents of these children, and a healthy control set of 1,775 children. They found nearly 400 inherited CNVs in autism subjects that did not occur in controls. They also analyzed a second cohort of 593 additional autism subjects, 1,109 corresponding parents, and 2,026 healthy controls. This second study found another set of nearly 400 inherited CNVs exclusive to children with autism. Surprisingly, no single gene was frequently disrupted in either set, and only a few genes harbored CNVs in both sets.

Although there was relatively little overlap between sets of CNVs found in the two cohorts, the CNVs tended to occur in genes that affected biological processes relevant to autism. "While individually, CNVs are rare, each of them often appearing only in one family in our study, we found in this study that CNVs tend to occur in genes with similar functional rol
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic variants linked to increased risk of common gynecological disease
2. New variants found that indicate a predisposition to type 2 diabetes
3. Autism genome project identifies genetic variants that may make people susceptible to disorder
4. Newly discovered gene variants lead to autism and mental retardation
5. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
6. New gene variants associated with glucose, insulin levels, some with diabetes risk
7. Identification of genetic variants affecting age at menopause could help improve fertility treatment
8. Common gene variants influence risk factor for sudden cardiac death
9. Common gene variants increase risk of hypertension, may lead to new therapies
10. International study identifies gene variants associated with early heart attack
11. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... 21, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market ... that it has filed provisional patent 62/192218 for ... This invention highlights next generation payment ... account, but also the user using unique personal ...
(Date:7/13/2015)... Calif. , July 13, 2015 ... developer of human interface solutions, today announced sampling ... touch and display driver integration (TDDI) product targeting ... the first to combine Synaptics , best-in-class ... proven display driver technology developed in the company,s ...
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... Speak at Advanced Identification ... Systems/Commercial Biometrics Conference, SAN ... leader in secure biometric co-processor solutions, announced today,that ... will,present "Secure Biometric Co-processor: Solving the Network Security,Puzzle" ...
... an increasingly used X-ray-based tool for providing a three-dimensional view ... scanning to diagnose injury, cancer and other health problems is ... some cases unnecessarily" What are the health consequences of having ... life" In a Nov. 29, 2007 article in The ...
... malaria parasite has been studied for decades, but surprisingly, ... to cause disease. In a groundbreaking study published November ... international research team has for the first time measured ... off during actual infection in humans, not in cell ...
Cached Biology News:Atmel's Biometric Co-processor Solution Featured at AIS/CBX 2Columbia researchers: Growth of CT scan use may lead to significant public health problem 2Columbia researchers: Growth of CT scan use may lead to significant public health problem 3Study of malaria parasite in patient blood finds distinct physiological states 2Study of malaria parasite in patient blood finds distinct physiological states 3Study of malaria parasite in patient blood finds distinct physiological states 4
(Date:7/29/2015)... ... July 29, 2015 , ... Asymmetrex, LLC founder ... evaluating the full range of capabilities of its unique cache of technologies for ... the day-to-day renewal and repair of normal tissues and organs. This property makes ...
(Date:7/28/2015)... , July 28, 2015  PDL BioPharma, Inc. ... announced that the Company will release its second quarter ... 2015, on Wednesday, August 5, 2015, after market close. ... that day at 4:30 p.m. Eastern Time to discuss ... call will be available via the webcast link on ...
(Date:7/28/2015)... DUBLIN , July 21, 2015 ... the addition of the "Biomedical Refrigerators and ... Growth, Trends and Forecast 2014 - 2022" ... global biomedical refrigerators and freezers market has been ... diagnostic centers, blood banks, and others. The others ...
(Date:7/28/2015)... MORRISTOWN, N.J. , July 28, 2015 /PRNewswire/ ... its second Phase 1 clinical trial with MMI-0100, ... that is being developed for pulmonary disorders characterized ... the United Kingdom , is ... study further evaluating the safety and tolerability of ...
Breaking Biology Technology:Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Moerae Initiates Lipopolysaccharide (LPS) Challenge Study of Inhaled MMI-0100 for Pulmonary Disease Following Encouraging Safety and Tolerability Observed in Single Ascending Dose Phase 1 Study 2
... - Dragon Pharmaceutical Inc. ("Dragon Pharma" or the "Company" TSX: DDD; OTCBB: DRUG), an ... March 31, 2010 . , , ... Quarter Ended March 31, 2010 , ... Company recorded $49.06 million of revenues for the quarter ended March ...
... 17 Sigma-Aldrich Corporation (Nasdaq: SIAL ) will be presenting at ... 1:15 PM CDT ( 2:15 PM EDT ) in Chicago, ... available at http://investor.sigmaaldrich.com/ .  Users can click the "Webcast" icon to access ... About ...
... , ... Company’s Certification Covers Advanced Mixed-Signal ASIC Design Services and CMOS Imaging Chips , ... Pasadena, California (PRWEB) May ... was certified to ISO 9001:2008 standards , by the registrar PJR. Forza is ...
Cached Biology Technology:Dragon Pharma reports 2010 first quarter financial results 2Dragon Pharma reports 2010 first quarter financial results 3Dragon Pharma reports 2010 first quarter financial results 4Dragon Pharma reports 2010 first quarter financial results 5Sigma-Aldrich Corporation to Present at the Baird's 2010 Growth Stock Conference on Thursday, May 20, 2010 2Forza Silicon Achieves ISO 9001 Certification 2
BD BioCoat Laminin 150 mm Culture Dishes...
...
The BD CBA Human Apoptosis Kit can be used to quantitatively measure,cleaved PARP, Bcl-2, and active Caspase-3 protein levels in a single sample. The,Kit performance has been optimized for analysis o...
... a software package that provides crystallographers ... custom buffer creation, set-up of experimental ... trials. The software helps crystallographers through ... protein crystallography: Design ...
Biology Products: