Navigation Links
Gene variants in autism linked to brain development
Date:3/1/2011

ols. The study team reinforced their findings using information from mouse models, showing that mice with abnormal motor and learning behaviors similar to human autistic behaviors were more likely to have CNVs in genes analogous to human autism genes.

"Because the gene alterations that we found influence brain development, our hope is that they may eventually provide clues to developing diagnostic tests as well as treatments for children with autism," said co-author and lead clinician Josephine Elia, M.D., a child psychiatrist at Children's Hospital.

Unlike changes to single bases in DNA, called single-nucleotide polymorphisms (SNPs or "snips"), CNVs are larger alterations in DNA structuremissing or repeated stretches of dozens or hundreds of bases in sequence. CNVs have been implicated in other neuropsychiatric disorders, such as schizophrenia, bipolar disorder and attention-deficit hyperactivity disorder (ADHD)the latter in a previous study by White and Elia.

In the current research, White and colleagues searched for CNVs in a discovery cohort of 631 children with autism, 1,162 parents of these children, and a healthy control set of 1,775 children. They found nearly 400 inherited CNVs in autism subjects that did not occur in controls. They also analyzed a second cohort of 593 additional autism subjects, 1,109 corresponding parents, and 2,026 healthy controls. This second study found another set of nearly 400 inherited CNVs exclusive to children with autism. Surprisingly, no single gene was frequently disrupted in either set, and only a few genes harbored CNVs in both sets.

Although there was relatively little overlap between sets of CNVs found in the two cohorts, the CNVs tended to occur in genes that affected biological processes relevant to autism. "While individually, CNVs are rare, each of them often appearing only in one family in our study, we found in this study that CNVs tend to occur in genes with similar functional rol
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic variants linked to increased risk of common gynecological disease
2. New variants found that indicate a predisposition to type 2 diabetes
3. Autism genome project identifies genetic variants that may make people susceptible to disorder
4. Newly discovered gene variants lead to autism and mental retardation
5. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
6. New gene variants associated with glucose, insulin levels, some with diabetes risk
7. Identification of genetic variants affecting age at menopause could help improve fertility treatment
8. Common gene variants influence risk factor for sudden cardiac death
9. Common gene variants increase risk of hypertension, may lead to new therapies
10. International study identifies gene variants associated with early heart attack
11. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... to date of the family of bacteria that ... strategies and reveals surprising findings about the bacteria,s ... public health strategies to control this respiratory disease, ... Genomic analysis of 343 strains of the ... collected over the last 100 years illustrates how ...
(Date:4/23/2014)... mammals, ravens form different types of social relationships ... also form strict dominance relations. From a cognitive perspective, ... ability in daily social life ("knowing who is nice ... have with each other sets the stage for "political" ... this study have been published in the scientific journal ...
(Date:4/22/2014)... behave at the dinner tablecut up their food and they,ll ... Behaviors , found that when 6-10 year old children ate ... as drumsticks, whole apples, or corn on the cob they ... "They were twice as likely to disobey adults and ... and Director of the Cornell Food and Brand Lab. , ...
Breaking Biology News(10 mins):Impact of whooping cough vaccination revealed 2Ravens understand the relations among others 2Biting vs. chewing 2
... many environmental issues facing our society are prevalent in ... endangered species have taken center stage. Our ecosystem ... among all species and the non-living environment. Predicting ... to the many environmental changes sweeping the globe is ...
... This release is available in Spanish . ... -rich in vegetables, fruits, nuts, whole grains and fish- appear ... the University of Navarra, published in the October issue of ... of mental disorders has been found to be lower in ...
... The secret lives of some of Africa,s iconic carnivores, including ... Animal Conservation , today. The results shed light on ... elusive meat eaters, such as the leopard. ... Conservation Society (WCS) and the Tanzania Wildlife Research Institute (TAWIRI) ...
Cached Biology News:A tree's response to environmental changes: What can we expect over the next 100 years? 2A tree's response to environmental changes: What can we expect over the next 100 years? 3Mediterranean diet associated with reduced risk of depression 2No place like home: Africa's big cats show postcode preference 2
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)... WASHINGTON , Jan. 14, 2014  3D Communications, a leading provider ... scientific, regulatory, business, and media events in the United ... its former associate Virginia Cox , JD, is returning to ... Virginia Cox re-joins 3D after more than two years ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. 14, ... with two institutes from the National Institutes of Health ... bringing safer, more effective treatments to patients on a ... for Advancing Translational Sciences (NCATS) and the National Eye ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... 20 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: ... specializing in the manufacture,research, development, marketing and ... launched its newest product, Shining Probiotics,Protein Powder, ... and Changchun markets. Shining Probiotics Protein ...
... Pharmaceuticals,Inc. (Nasdaq: CADX ), a biopharmaceutical company ... principally,for use in the hospital setting, announced today ... present the corporate overview on,Thursday, September 27, 2007 ... during the UBS 2007 Global Life Sciences Conference ...
... Lexicon,Pharmaceuticals, Inc. (Nasdaq: LXRX ) today announced ... executive officer, will present,at the UBS Global Life Sciences ... York, New York on Tuesday, September 25, 2007 at ... presentation may be accessed on its,corporate website at ...
Cached Biology Technology:China-Biotics, Inc. Launches Shining Probiotics Protein Powder 2Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at UBS 2007 Global Life Sciences Conference 2Lexicon Pharmaceuticals to Present at the UBS Global Life Sciences Conference 2
human Exodus-2 Research Focus: cytokine/growth factor Storage Temperature: -20C Shipping Temperature: 4C...
MAb to IgG2 (Fc gamma-2) IgG2 (Fc, gamma-2 epitope)...
... formulated for non-denaturing polyacrylamide and agarose gel ... solution contains a bromophenol blue tracking dye ... sample loading. EDTA has been included to ... SDS has been added to help dissociate ...
... Polyclonal Antibody Description: ... polyclonal antibody. Detects 70 kDa YAP ... blotting and immunohistochemistry. ... Storage: -20C ...
Biology Products: