Navigation Links
Gene variants in autism linked to brain development
Date:3/1/2011

New research on the genomics of autism confirms that the genetic roots of the disorder are highly complicated, but that common biological themes underlie this complexity. In the current study, researchers have implicated several new candidate genes and genomic variants as contributors to autism, and conclude that many more remain to be discovered. While the gene alterations are individually very rare, they mostly appear to disrupt genes that play important functional roles in brain development and nerve signaling.

While an association between genomic variants in certain nervous system processes and autism has been hypothesized in the past, the current research definitively links these biological functions to autism.

"This large study is the first to demonstrate a statistically significant connection between genomic variants in autism and both synaptic function and neurotransmission," said senior author Peter S. White, Ph.D., a molecular geneticist and director of the Center for Biomedical Informatics at The Children's Hospital of Philadelphia. Synapses are the contact points at which nerve cells communicate with other nerve cells, while neurotransmitters are the chemical messengers carrying those signals.

"Prior genomic studies of autism have successfully identified several genes that appear to confer risk for autism, but each gene appears to contribute to only a small percentage of cases," said the lead author, Xiaowu Gai, Ph.D. "Our approach considered whether groups of genes with common biological functions collectively accounted for a greater percentage of autism risk."

The study appears online today in the journal Molecular Psychiatry.

White and colleagues compared the DNA of more than 1,000 children with autism to control sets of healthy subjects, searching for gene variants called copy number variations (CNVs) appearing in the genomes of autistic individuals and their families, but not in healthy contr
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic variants linked to increased risk of common gynecological disease
2. New variants found that indicate a predisposition to type 2 diabetes
3. Autism genome project identifies genetic variants that may make people susceptible to disorder
4. Newly discovered gene variants lead to autism and mental retardation
5. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
6. New gene variants associated with glucose, insulin levels, some with diabetes risk
7. Identification of genetic variants affecting age at menopause could help improve fertility treatment
8. Common gene variants influence risk factor for sudden cardiac death
9. Common gene variants increase risk of hypertension, may lead to new therapies
10. International study identifies gene variants associated with early heart attack
11. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... the birds and the bees. But that old ... fertilized. The fertilization process for flowering plants is ... male and female reproductive cells. New research from ... Munich, and including Carnegie,s Wolf Frommer, David Ehrhardt, ... signaling process that guides flowering plant fertilization. It ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
(Date:8/21/2014)... Fla. , Aug. 21, 2014 /PRNewswire-iReach/ ... that it has agreed to a partnership ... Orlando,s fastest growing Certified Nursing ... Gabriel Health Institute  an exclusive member of ... result, Binary Biometrics will improve its service ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
... more intense rainstorms and more frequent heat waves are ... when climate change is mentioned. Now, two University of ... transmission in wild birds can be added to the ... used a mathematical model to explore the consequences of ...
... of beetles and only two species of the tuatara, a ... Zealand. Crocodiles and alligators, while nearly 250 million years old, ... "winners" including mammals and many species of birds and ... biology. Scientists have often posited that because ...
... marine whelk, Solenosteira macrospira . He does all the work ... few of the baby snails are his own. The surprising ... S. macrospira in a small club of ... and sibling cannibalism, and the species has one of the most ...
Cached Biology News:Climate change could increase levels of avian influenza in wild birds 2Climate change could increase levels of avian influenza in wild birds 3Why are there so many species of beetles and so few crocodiles? 2Why are there so many species of beetles and so few crocodiles? 3Male snails babysit for other dads 2Male snails babysit for other dads 3
(Date:8/22/2014)... August 22, 2014 The Global and ... study on the current state of the Diabetes Drug ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:8/22/2014)... Canada (PRWEB) August 22, 2014 ... in model organisms can be accelerated by exome ... and manufacturing technologies, the custom SeqCap EZ Developer ... research. , Mr. Watson will additionally present how ... with commercially available human and mouse exome kits. ...
(Date:8/21/2014)... team including DESY scientists has observed tiny quantum vortices ... in the journal Science that the exotic ... nanodroplets. It is the first time that the quantum ... of what is known as superfluid helium, have been ... expectations," says Andrey Vilesov of the University of Southern ...
(Date:8/21/2014)... The College of New Rochelle announced ... the Mid-Hudson Region to be designated as a START-UP ... from qualified “high-technology” businesses that align with the College’s ... have been selected for the START-UP NY program and ... stimulate economic development in New York by growing business ...
Breaking Biology Technology:Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Scientists observe quantum vortices in cold helium droplets 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3
... . , What would be a case for ... for a micro engine. If it sputters, this is caused ... with its running. Researchers at the University of Stuttgart and ... observed this with a heat engine on the micrometre scale. ...
... Dec. 12, 2011  Kensey Nash Corporation (Nasdaq: ... by Spectranetics Corporation (Nasdaq: SPNC ) that ... of the endovascular product lines purchased from Kensey Nash ... $6 million milestone payable to Kensey Nash.  As previously ...
... 12, 2011  Fox Insurance Company, a Medicare Part D ... judgment in the arbitration between the company and ProCare, ... million, following a suit against ProCare based on Fox,s ... Nathan M. Barotz, chairman of Fox Insurance Company ...
Cached Biology Technology:The world's smallest steam engine 2The world's smallest steam engine 3Fox Insurance Company Awarded $3.3 Million in Arbitration Against Former Pharmacy Benefit Manager 2
Mouse monoclonal antibody to ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2...
... Object Parametric Analyzer and Sorter) large particle ... advantages of flow cytometry to applications that ... automated analysis and sorting. Our instruments ... traditional flow cytometers, but are designed to ...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
... raised against a partial recombinant ... SF3B2 (NP_006833, 592 a.a. ... protein with GST tag. ... NM_006842 Protein ...
Biology Products: