Navigation Links
Gene variants in autism linked to brain development
Date:3/1/2011

New research on the genomics of autism confirms that the genetic roots of the disorder are highly complicated, but that common biological themes underlie this complexity. In the current study, researchers have implicated several new candidate genes and genomic variants as contributors to autism, and conclude that many more remain to be discovered. While the gene alterations are individually very rare, they mostly appear to disrupt genes that play important functional roles in brain development and nerve signaling.

While an association between genomic variants in certain nervous system processes and autism has been hypothesized in the past, the current research definitively links these biological functions to autism.

"This large study is the first to demonstrate a statistically significant connection between genomic variants in autism and both synaptic function and neurotransmission," said senior author Peter S. White, Ph.D., a molecular geneticist and director of the Center for Biomedical Informatics at The Children's Hospital of Philadelphia. Synapses are the contact points at which nerve cells communicate with other nerve cells, while neurotransmitters are the chemical messengers carrying those signals.

"Prior genomic studies of autism have successfully identified several genes that appear to confer risk for autism, but each gene appears to contribute to only a small percentage of cases," said the lead author, Xiaowu Gai, Ph.D. "Our approach considered whether groups of genes with common biological functions collectively accounted for a greater percentage of autism risk."

The study appears online today in the journal Molecular Psychiatry.

White and colleagues compared the DNA of more than 1,000 children with autism to control sets of healthy subjects, searching for gene variants called copy number variations (CNVs) appearing in the genomes of autistic individuals and their families, but not in healthy contr
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic variants linked to increased risk of common gynecological disease
2. New variants found that indicate a predisposition to type 2 diabetes
3. Autism genome project identifies genetic variants that may make people susceptible to disorder
4. Newly discovered gene variants lead to autism and mental retardation
5. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
6. New gene variants associated with glucose, insulin levels, some with diabetes risk
7. Identification of genetic variants affecting age at menopause could help improve fertility treatment
8. Common gene variants influence risk factor for sudden cardiac death
9. Common gene variants increase risk of hypertension, may lead to new therapies
10. International study identifies gene variants associated with early heart attack
11. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Wash. -- Like a hungry diner ripping open a ... into electricity must tear open a hydrogen molecule. Now ... holding onto the two halves of its hydrogen feast. ... how to make the catalyst work better for alternative ... scientists have shown precisely where the hydrogen halves end ...
(Date:4/23/2014)... have conclusive evidence that the source of a unique ... and called the "bio-duck," is the Antarctic minke whale ... submarine personnel in the 1960s who thought it sounded ... at various locations in the Southern Ocean, but its ... February 2013, an international team of researchers deployed acoustic ...
(Date:4/23/2014)... Aires yesterday, Argentina joins the European Molecular Biology ... move strengthens the ties between the European and ... scientists access to EMBL,s world-class facilities and programs, ... its inception, fostering excellent life science research and ... of EMBL,s mission," says EMBL Director General Iain ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3
... Pyrazinamide (PZA) has been used in conjunction with other medications ... how the drug killed TB bacteria. PZA plays a unique ... six months and is used frequently to treat multi-drug resistant ... Hopkins Bloomberg School of Public Health, suggests that PZA binds ...
... molecular biologist Joseph M. Miano, Ph.D., and clinician Craig ... Aab Cardiovascular Research Institute and Benson is chief resident ... the University of Rochester Medical Center. Though the chance ... enthusiasm, intense curiosity and a little detective work led ...
... some of the unlikely bat habitats that could be ... the Ecological Society of America,s (ESA) 96th Annual Meeting ... other technologies relatively new to the field of ecology, ... bat behavior and the effectiveness of acoustic deterrents in ...
Cached Biology News:Researchers decode workings of mysterious, but critical TB drug 2In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 2In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 3In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 4Scientists explore the role of aeroecology in bat conservation and ecosystem health 2Scientists explore the role of aeroecology in bat conservation and ecosystem health 3
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... 2014 Histogen, Inc., a regenerative medicine ... grown under simulated embryonic conditions, today announced that they ... Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary ... agreement is an amendment to the existing license between ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 EquitiesIQ, a ... Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical company ... the wound care market. , Free report download: ... with a seasoned management team and Board, which launched ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Troy, N.Y. A new research discovery at Rensselaer ... frames for aircraft, watercraft, and automobiles. , Epoxy composites ... jets, planes, and other vehicles. Composite material frames are ... vehicle and boosts fuel efficiency. The downside is that ...
... NATURAL FUELS INDUSTRIES, INC. (Pink Sheets: VGPR) today announced ... the Company to "Fully Compliant", its highest tier for ... over-the-counter into easily identifiable tiers that inform investors whether ... a timely manner. Subsequent to NFI,s recent filing, ...
... ACF Manufacturing Drives Aggressive Conversion ProgramST. LOUIS, March 26 ... materials and services for upstream and downstream processes in ... a member of the Sigma-Aldrich Group (Nasdaq: ... of its dry powder cell culture media continuous milling ...
Cached Biology Technology:Fitter frames: Nanotubes boost structural integrity of composites 2Pink OTC Markets Moves Natural Fuels Industries to Top Tier 2SAFC Biosciences(TM) Completes Conversion of Lenexa Media Milling Facility to Animal Component Free 2SAFC Biosciences(TM) Completes Conversion of Lenexa Media Milling Facility to Animal Component Free 3SAFC Biosciences(TM) Completes Conversion of Lenexa Media Milling Facility to Animal Component Free 4
TAR DNA binding protein...
D-biotin *50 mM aqueous solution* Secondary Detection Biotin–Avidin Detection Reagents Other...
6-(2,4-dinitrophenyl)aminohexanoic acid, succinimidyl ester (DNP-X, SE)...
... High Sensitivity Freezing Point Osmometer for 10 L sample. Ideal for small volume applications, including pediatric, ... Ready to run in less than 3 minutes after turn-on. ... ... ...
Biology Products: