Navigation Links
Gene variant increases fatty liver risk and fibrosis progression
Date:6/28/2011

New research confirms that a variant on the patatin-like phospholipase-3 (PNPLA3) gene increases risk of steatosis and fibrosis progression in patients with chronic hepatitis C virus (HCV). The PNPLA3 single nucleotide polymorphism (SNP) rs 738409 may represent an important genetic predictor and potential therapeutic target in chronic HCV liver damage. Study details are published in the July issue of Hepatology, a peer-reviewed journal of the American Association for the Study of Liver Diseases.

According to a report by the World Health Organization (WHO) roughly 170,000 million individuals worldwide are infected with chronic HCVa leading cause of liver disease and liver transplantation. Research shows that only 20% of HCV patients develop cirrhosis, but fibrosis progression remains highly unpredictable. A recent study identified a genetic variant in the PNPLA3 gene (rs738409 C>G) associated with fatty liver (steatosis) and was also found to influence fibrosis severity in non-alcoholic fatty liver disease.

The present study led by Christophe Moreno, MD, PhD, from Erasme Hospital and the Universit Libre de Bruxelles in Belgium examined the impact of the rs738409 polymorphism and other variants in the PNPLA3 gene on liver damage and response to antiviral therapy in chronic HCV. Researchers recruited 527 Caucasian patients with chronic HCV from centers in Belgium (n=229), Germany (n=171), and France (n=137). More than half of the participants were male with a mean age ranging from 47 to 52 years.

"Our findings show that the PNPLA3 SNP rs738409 favors steatosis and fibrosis progression in chronic HCV," confirmed Dr. Moreno. After adjusting for age, gender, body mass index, alcohol consumption and diabetes, the team determined that carriers of two copies of the rs738409 mutant G allele (i.e. GG homozygotes) remained at higher risk for developing fatty liver, fibrosis, and fibrosis progression, with an odds ratio of 2.55, 3.13 and 2.64, respectively.

Further analysis determined that the SNP rs738409 was not associated with antiviral treatment failure and did not influence clinical or biological variables such as stage of fibrosis, alanine aminotransferase (ALT), viral load, or type 2 diabetes. "This SNP represents a valuable genetic predictor of liver damage," concluded Dr. Moreno. "Further studies are needed to confirm our results and evaluate the PNPLA3 gene variant as a potential therapeutic target in chronic HCV."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Study finds genetic variant plays role in cleft lip
2. Interaction between gene variants may alter brain function in schizophrenia
3. Study identifies genetic variants giving rise to differences in metabolism
4. New gene variants present opportunities in nutrigenomics
5. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
6. International study identifies gene variants associated with early heart attack
7. Common gene variants increase risk of hypertension, may lead to new therapies
8. USC researchers identify gene variant associated with both autism and gastrointestinal dysfunction
9. Antibody key to treating variant CJD, scientists find
10. Common gene variants influence risk factor for sudden cardiac death
11. Identification of genetic variants affecting age at menopause could help improve fertility treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... and DE SOTO, Kansas ... U.S.-based Stroke Detection Plus® to offer Oncimmune,s Early ... assessment and early detection of lung cancer ... employers, unions and individuals. --> Early CDT®-Lung ... and individuals. --> Oncimmune, a leader in ...
(Date:3/2/2016)... 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced the ... a Service Market 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ...
(Date:3/1/2016)... -- (RSAC Booth #3041) – True fraud costs business $9 ... lost to false positives, where good customers are pushed ... the RSA Conference 2016, NuData Security is calling for a ... devaluing the data fraudsters have in abundance in favor ... --> --> Cheap and readily available ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... , ... April 27, 2016 , ... ... Lewis Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual Property ... international electrical, mechanical and electromechanical patent applications. He has an electrical engineering and ...
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg Instruments, a ... technology innovation for its Volume Pattern Generator (VPG) line of lithography systems. The ... photomasks as well as a solution for mid volume direct write lithography applications. ...
(Date:4/26/2016)... ... April 26, 2016 , ... BioFactura, Inc ., a ... round of financing. Healthy investor interest drove significant oversubscription of the original $1.5M ... known as biosimilars, to the advanced preclinical stages. , Chief Executive Officer and President, ...
(Date:4/26/2016)... ... , ... uBiome, the leading microbial genomics company, welcomes Neil Grimmer, Co-founder and ... to co-founding Plum in 2007, Neil Grimmer was Vice President of Strategy and Innovation ... designer of ideas, products, and brands, Grimmer has been at the forefront of launching ...
Breaking Biology Technology: