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Gene variant increases breast cancer risk
Date:3/14/2008

two variants in both copies of their AKAP9 genes, the risk of developing breast cancer in the course of their lifetimes is elevated by 17 percent. In women from breast cancer families, this effect is even more substantial: their risk is increased by 27 percent. If only one of the AKAP9 copies is affected, the breast cancer risk is only slightly elevated by approximately eight percent or twelve percent for women from breast cancer families, respectively.

This shows that the AKAP9 variants have much less effect on breast cancer risk than, for example, BRCA mutations. On the other hand, these variants are much more common in the population. We also do not know yet which control cycles of the cell metabolism are affected and how this can lead to cancer, said Barbara Burwinkel to qualify the finding. But there is already evidence suggesting that the two variants also increase the risk of developing lung cancer or colon cancer.


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Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

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