Navigation Links
Gene variant increases breast cancer risk
Date:3/14/2008

This release is available in German.

In roughly five to ten percent of breast cancer cases there is a family history of breast cancer i.e., hereditary and, thus, genetic factors play a role here. Alterations in the genes known as BRCAI and BRCAII are a major cause of familial breast cancer these are responsible for roughly 25 percent of such cases.

In Germany, 75 percent of familial breast cancers are not attributable to mutations in BRCAI and BRCAII. We assume that these cancers are caused in part by rare mutations and in part by unfavorable combinations of risk variants in various genes, which, on their own, have only little effect. Only very few of these have been identified so far we are searching for the other ones, said Associate Professor Dr. Barbara Burwinkel of the DKFZ.

Members of the AKAP protein family are responsible for transmitting important signals in a cell. Scientists have suspected these proteins to be involved in cancer development. A large international study headed by Barbara Burwinkel has now delivered proof that this is true for breast cancer.

In collaboration with the German Consortium for Familial Breast and Ovarian Cancers, the research team studied six gene variants in the AKAP family. Two of these, both located on the AKAP9 gene, have indeed been found to be associated with an increased breast cancer risk. Since the two gene variants are always inherited together, further investigations will have to determine whether one of these or both variants in combination are responsible for the risk effect. This finding was confirmed by a large international study in collaboration with researchers from Germany, the United Kingdom, the U.S.A. and Australia. The study included 9,523 breast cancer patients including 2,795 familial breast cancer cases and almost 14,000 healthy women.

For women carrying the
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genetic variants associated with lipid levels, risk for coronary artery disease
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
4. Breastfeeding boost IQ in infants with helpful genetic variant
5. New genetic variant associated with prostate cancer in African-Americans
6. Genetic variant linked to odor perception
7. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
8. Washington University increases fleet of Roche Genome Sequencer FLX Systems
9. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
10. New study increases concerns about climate model reliability
11. Waterborne carbon increases threat of environmental mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 The biosensors market is proving highly ... into newer sectors, and development of devices resulting in ... has seen the entry of multiple participants each year ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... the Global Biosensors Market ( http://www.frost.com/nee9 ), finds ...
(Date:8/3/2015)... Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... today announced that members of the executive management team ... Crest Global Technology Leadership Forum on Tuesday, August 11, ... be held at the Sonnenalp Resort in ... may include forward-looking information. An audio webcast of the ...
(Date:7/31/2015)... julho de 2015 A 10 a. ... realizada pela BGI de 22-25 de outubro de 2015, em ... A conferência está celebrando seu 10 o. aniversário este ... tornou uma das reuniões mais influentes do mundo no ... dinâmicos, entusiastas e prazerosos. A ICG-10 ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... in lipid-based nanoparticles drastically reduces the number and size ... researchers at The University of Texas M. D. Anderson ... Center report in the Jan. 15 edition of Cancer ... separately but had their most powerful effect when administered ...
... evolve significantly long after they were established in Europe, ... continent, according to new research published this week in ... USA. , Professor Joao Zilhao of the University of ... in Europe compared the features of an early modern ...
... (known as impact factors) are distorting publishing and science. , ... papers in scientific journals. It was developed as a simple ... importance of a journal to its field. , But ... popularity of this ranking is distorting the fundamental character of ...
Cached Biology News:Dual gene therapy suppresses lung cancer in preclinical test 240,000-year-old skull shows both modern human and Neandertal traits 2Are journal rankings distorting science? 2
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/53wxp3/israel_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Sensors market is estimated at $0.19 billion by 2018 ... The near future will bring biomedical sensors ... individual. These sensors can be set to trigger alerts ...
(Date:8/31/2015)... SYDNEY , Aug. 31, 2015  US-Australian ... NVGN ) today confirmed its comprehensive scientific ... ground-breaking technology platforms in areas of unmet patient ... through the remaining preclinical projects prior to entering ... lead compounds. Acting Chief Executive Officer, ...
(Date:8/31/2015)... Grove, IL (PRWEB) , ... August 31, 2015 ... ... impurities (PGIs), as a high priority in the drug development approval process. Thus, ... , This year, Regis Technologies, Inc., a Chicago-based CMO, has been hosting ...
(Date:8/28/2015)... Aug. 28, 2015 Research ... of the "Global & USA BioSimilar Market Analysis ... The highly awaited US Biosimilar market will be initiated ... biologic, Zarxio. How will the global market react? Will ... that biosimilars could save the US economy up to ...
Breaking Biology Technology:Israel Biomedical Sensors Market 2015 - Growth, Trends & Forecasts to 2020 2Novogen Announces The Outcome Of A Comprehensive Science Review 2Novogen Announces The Outcome Of A Comprehensive Science Review 3Novogen Announces The Outcome Of A Comprehensive Science Review 4Novogen Announces The Outcome Of A Comprehensive Science Review 5Novogen Announces The Outcome Of A Comprehensive Science Review 6Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3
... nation's fifth largest school district is being outfitted with ... Inc. , to deter sexual predators from entering school ... to develop hybrid car batteries and energy-efficient building systems, ... utilizing digital identification checkpoints in 250 Broward County ...
... - Teresa Esser sees incredible opportunity for ... new director of the Milwaukee-based Silicon Pastures ... that opportunity realized. , ,While others are talking about ... particularly in the tech sector, Esser sees plenty of ...
... renewable fuel standard contained in the Energy Policy Act ... Congressman Ron Kind have called for a much stronger ... the Farmers Cooperative Shipping and Supply Association, Doyle and Kind ... and they touted the economic and energy independence benefits of ...
Cached Biology Technology:Florida schools employ Johnson Controls technology to stop sex predators 2New Silicon Pastures director envisions more home cooking for Wisconsin angels 2New Silicon Pastures director envisions more home cooking for Wisconsin angels 3New Silicon Pastures director envisions more home cooking for Wisconsin angels 4New Silicon Pastures director envisions more home cooking for Wisconsin angels 5New Silicon Pastures director envisions more home cooking for Wisconsin angels 6Doyle, Kind call for higher renewable fuel standard 2Doyle, Kind call for higher renewable fuel standard 3
... II inhibitor (IC50 = 59.2 M). ... H 32 O 13 MolWeight: ... RT CAS: ... Soluble to 100 mM in DMSO ...
POU domain, class 2, transcription factor 2,...
NAP-2 (5C7)...
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
Biology Products: