Navigation Links
Gene therapy shows promise against age-related macular degeneration
Date:4/29/2011

BOSTON (April 29, 2011) A gene therapy approach using a protein called CD59, or protectin, shows promise in slowing the signs of age-related macular degeneration (AMD), according to a new in vivo study by researchers at Tufts University School of Medicine. Led by senior author Rajendra Kumar-Singh, PhD, the researchers demonstrated for the first time that CD59 delivered by a gene therapy approach significantly reduced the uncontrolled blood vessel growth and cell death typical of AMD, the most common cause of blindness in the elderly. The study was published on April 28 in PLoS ONE.

Activation of the complement system, a part of the immune system, is responsible for slowly killing cells in the back of the eye, leading to AMD. Activation of this system leads to the generation of pores or holes known as 'membrane attack complex' or MAC in cell membranes. CD59 is known to block the formation of MAC.

"CD59 is unstable and hence previous studies using CD59 have had limited success. The gene therapy approach that we developed continuously produces CD59 in the eye and overcomes these barriers, giving us renewed hope that it can be used to fight the progression of AMD and potentially other diseases," said Kumar-Singh.

Kumar-Singh is associate professor in the department of ophthalmology at Tufts University School of Medicine (TUSM) and member of the genetics; neuroscience; and cell, molecular, and developmental biology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

Kumar-Singh and colleagues delivered CD59 to the eye using a deactivated virus similar to one previously shown to be safe in humans. Using an established mouse model of age-related macular degeneration, they found that eyes treated with CD59 had 62 percent less uncontrolled blood vessel growth and 52 percent less MAC than controls.

"Treatment was effective when administered at a very specific location beneath the retina,
'/>"/>

Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breast cancer cells recycle to escape death by hormonal therapy
2. On the trail of a targeted therapy for blood cancers
3. Researchers identify promising gene target for neuroblastoma therapy
4. Gene therapy restores vision to mice with retinal degeneration
5. How eating fruit and vegetables can improve cancer patients response to chemotherapy
6. Researchers at UH explore use of fat cells as heart attack therapy
7. Scientist clears hurdles for muscular dystrophy therapy
8. Medicare coding for maggots and maggot therapy
9. Gene therapy corrects sickle cell disease in laboratory study
10. UC Davis researchers exploring gene therapy to fight AIDS
11. Leeds research points to new therapy for hepatitis C treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... WA, famed for its wine, is about to become famous for ... with under global warming. , A fossil coral reef, lying several ... River, points to the high point of the last major sea ... for Coral Reef Studies (CoECRS) consider the reef ?the most southerly ...
... director's cut. In much the same way that numerous films ... footage, a molecular process called alternative splicing enables a single ... created by a team of researchers at Rockefeller University and ... Nature, shows for the first time how the specific location ...
... detail one remembers of an event depends on whether a ... memory. , The research may help to explain why sometimes ... car accident, and yet vividly recall all of the details ... magnetic resonance imaging (fMRI), the scientists were able to view ...
Cached Biology News:Reef warns of sea level rise 2Reef warns of sea level rise 3RNA map provides first comprehensive understanding of alternative splicing 2RNA map provides first comprehensive understanding of alternative splicing 3RNA map provides first comprehensive understanding of alternative splicing 4Memories: It's all in the packaging, scientists say 2
(Date:4/17/2015)... 2015 LC Sciences LLC, a ... today that it is seeking beta testers for ... PCR based targeted sequencing technology. The system offers ... enables accurate detection of rare variants. It utilizes ... The company will collaborate with beta testers to ...
(Date:4/16/2015)... and OSAKA, Japan ... Cell Research Application (CiRA) of Kyoto University and ... they will work together to develop clinical applications ... as heart failure, diabetes mellitus, neurological disorders and ... Cell Applications" (T-CiRA) is designed to expedite multiple ...
(Date:4/16/2015)... Capillus, LLC announces plans to expand ... Europe and Asia. The Miami-based medical device manufacturer ... Business Development Director of Svenson Group Europe, as ... professional achievements include increasing the number of Svenson ... the Portuguese marketplace with centers in Lisbon and ...
(Date:4/16/2015)... Grove, IL (PRWEB) April 16, 2015 ... the American Association for Cancer Research (AACR) annual ... the Pennsylvania Convention Center, starting Saturday, April 18, in ... AACR holds claim to title of the oldest and ... journals, provides fellowships and grants, and partners with survivors ...
Breaking Biology Technology:LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... , , ... (Nasdaq: MASI ), the inventor of Pulse ... announced that its Radical-7 and Rad-57 Pulse CO-Oximeters have ... Army. AWR certification is a fundamental milestone that allows ...
... Sept. 3 Stryker Corporation (NYSE: SYK ) announced today ... September 15, 2009 - 8:00 a.m. Eastern Time , Morgan ... , September 22, 2009 - 2:00 p.m. Eastern Time , ... , A simultaneous webcast of the Company,s presentations will be ...
... , , TONBRIDGE, ... are trapped in a postcode lottery after Department of Health (DH) ... over who is eligible for the jab. , , ... Health Authority (SHA) has advised all Primary Care Trusts (PCTs) in ...
Cached Biology Technology:Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4Stryker to Present at Investor Conferences 2Health Workers Face Postcode Lottery for Swine Flu Vaccine, Chemist+Druggist Reveals 2
... contains a precipitant to ensure that the samples ... to allow the user to follow the progress ... ABgene ® s proprietary mixture of red ... composition used in ReddyRun™ molecular weight markers. It ...
... This CLS number is ... created to easily match ... showing no availability yet, ... old Sigma-Aldrich number (Z71,381-3) ...
Excellent safety and durability., Remote control can be easily operated in your hand., Constant voltage control with 2 sets of terminals., Precise and durable circuit design. ...
Gel Loading Buffer contains a precipitant to ensure that the samples sink into the wells and a tracking dye to allow the user to follow the progress of electrophoresis....
Biology Products: