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Gene therapy restores vision to mice with retinal degeneration
Date:10/16/2008

nglion cells. Electrophysiological examination of the melanopsin-expressing cells revealed that all responded to light, although the neuronal signal was delayed and persisted after the light signal had stopped, which is typical for a melanopsin-mediated signal. Two behavioral tests verified that the treated mice which otherwise would have been essentially blind had enough vision to find a darkened refuge in an otherwise brightly-lit area and to successfully learn that a light indicated a safe platform to which they could swim.

"The same level of melanopsin expression in a human retina might allow someone who otherwise would be totally blind to read newspaper headlines, but the slowness of the response would be a problem," Masland says. He notes that another group's gene therapy experiments published earlier this year were similar but used a protein that requires a level of light comparable to looking directly into a bright sky for a whole day, which would eventually damage the retina. "Before planning clinical trials, we need to develop a more sensitive version of the other protein, channelrhodopsin-2, or a faster-responding melanopsin, which we are working on."


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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

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