Gene therapy corrects sickle cell disease in labora...(s in humans he cautioned that technical ...)

Date:12/3/2008

s in humans, he cautioned that technical barriers still need to be overcome. "It is far easier to achieve high levels of gene insertion into mouse cells than into human cells," he said. "In our mouse experiments, we routinely saw one or two copies of the gamma-globin gene inserted into each cell. However, in humans this insertion rate is at least a hundred-fold less."

Persons' laboratory is currently working with other animal and human cells to develop methods to achieve a high enough gene insertion rate to make the gene therapy clinically useful.

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Contact: Summer Freeman summer.freeman@stjude.org 901-595-3061 St. Jude Children's Research Hospital Source:Eurekalert

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