Navigation Links
Gene therapy anti-cancer research featured in Scientific American
Date:8/22/2008

BIRMINGHAM, Ala. Scientific American magazine focused on two University of Alabama at Birmingham (UAB) Comprehensive Cancer Center researchers in a news story on experimental next-generation anti-cancer therapies.

David T. Curiel, M.D., Ph.D., is a UAB professor of medicine and director of the human gene therapy division, and Ronald Alvarez, M.D., is a UAB professor of medicine and director of the gynecologic oncology division.

Both doctors are featured in a Scientific American special cancer edition, and both served as co-authors on the story "Tumor-busting viruses." The editors chose Curiel and Alvarez because of their research into a field called viral gene therapy, or virotherapy.

Virotherapy involves an experimental technique to target viruses to cancer cells while leaving healthy cells untouched. The viruses are genetically engineered to kill tumor cells in different ways. One way is by adopting the viruses' natural ability to invade and reproduce as a way to deliver target genes that make tumor cells more susceptible to existing chemotherapies.

Curiel and Alvarez have been testing this concept with a virus compound called adenovirus in women with recurrent ovarian or other gynecological cancers. The clinical trial is still in the early stages, yet the compound has shown anti-tumor effects that appear safe to most patients, Curiel said.

"We envision a substantial role for viruses that is, therapeutic viruses in 21st-century medicine," Curiel and Alvarez wrote in wrote in the story.

First proposed in the 1940s, virotherapy now relies heavily on adenoviruses, a cause of the common cold that has been studied and altered extensively for medical research. Adenoviruses have the ability to shuttle targeted segments of DNA into a tumor cell and make biochemical changes that minimize damage to healthy cells.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Page: 1

Related biology news :

1. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
2. Immunotherapy in high-risk pediatric sarcomas shows promising response
3. Anti-HIV therapy boosts life expectancy more than 13 years
4. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
5. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
6. Prostate cancer vaccines more effective with hormone therapy
7. New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
8. Caution on stem cell therapy
9. Potential therapy discovered for hypophosphatasia, a congenital form of rickets
10. UF researchers develop improved gene therapy agent
11. Gene therapy slows progression of fatal neurodegenerative disease in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 21, 2017 , ... ... top executive talent in the life sciences industry, today announces a strategic partnership ... The partnership takes full advantage of Beaker’s expertise in executive recruitment solutions, providing ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... in designating infertility as a disease, bringing new hope for prospective parents who ... 2017 annual meeting to back the World Health Organization’s designation in hopes of ...
(Date:6/22/2017)... ... June 22, 2017 , ... RURO, ... of Limfinity® version 6.5, a content-packed update to the Limfinity® framework. , LimitLIS® ... larger and more diverse base of customers among labs and other businesses. Limfinity® ...
(Date:6/20/2017)... ... June 20, 2017 , ... HorizonScan is providing food ... the most likely threat to their products at the annual IFT conference in ... annual food expo attracts over 20,000 attendees representing food science professionals from over ...
Breaking Biology Technology: