Navigation Links
Gene therapy a step closer to mass production
Date:6/24/2010

EUREKA project E! 3371 Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells. These new agents, derivatives of cationic amphiphilic 1,4-dihydropyridine (1,4-DHP), avoid the problems of the recipient's immune system reacting against a viral carrier. The project partners have developed methods to produce them in large amounts, which solves another of the problems with viral delivery. But the greatest advantage is that the new compounds are significantly more effective at delivering DNA into cell nuclei than other standard synthetic carriers; increasing the chance of the DNA successfully controlling the defective genes, and the disease.

Gene therapy involves the insertion of DNA into human cells within the body to treat disease. The technique is still in its early days, and has been demonstrated successfully only in the last decade. Most investigation has been into the possibilities for treating hereditary diseases related to a genetic defect, and the technique also has potential uses in treating the early stages of cancer, and in cardiovascular and neurodegenerative diseases.

Gene therapy faces many difficulties as a practical method; not the least of which is that DNA is a large and complicated structure which needs to be delivered and attached to the correct section of the recipient's set of DNA. A number of methods are in use or under investigation for introducing DNA into cells (a process known as transfection) using viruses, chemical agents or physical injection.

Viruses or chemical carriers

With viral carriers, the DNA to be introduced is injected into the virus, which carries it into the cell by way of a vesicle formed around the virus particle by the cell wall. Once inside the cell, the vesicle breaks down and the virus injects the DNA into the cell's nucleus. The viral route does, however, have major disadvanta
'/>"/>

Contact: Piotr Pogorzelski
piotr.pogorzelski@eurekanetwork.org
322-777-0979
EUREKA
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UF oncologists fight leukemia with two-pronged therapy, clinical trials planned
2. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
3. Making personalized lung cancer therapy a reality in Europe
4. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
5. 4-D software helps adjust for breathing when treating lung cancer with radiotherapy
6. Tool allows precise targeting of radiotherapy for cancer radiation therapy
7. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
8. Smoking during radiation therapy for head and neck cancers linked to poorer outcomes
9. JDRF partners with LCT to test encapsulated cell replacement therapy for the treatment of diabetes
10. Concord Medical Enters Agreement to Acquire Four Radiotherapy and Diagnostic Imaging Centers in Hebei Province
11. Lengthening time a drug remains bound to a target may lead to improving diagnostics, therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene therapy a step closer to mass production
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... ON (Dec. 22, 2011) - Drugs used to overcome ... study led by Gerry Wright, scientific director of the ... McMaster University. "Our study found that certain proteins, ... to proteins important in cancer," says Wright about the ...
... 2011(BRONX, NY) Researchers at Albert Einstein College of Medicine ... mechanism by which cells control the survival of messenger RNA ... pertain to mRNAs that help regulate cell division and could ... research is described in today,s online edition of the journal ...
... tragic losses to life, property, and the environment. But ... from done. Without vegetation, bare, burnt soil lies vulnerable ... regeneration. Now Assaf Inbar, a graduate student ... together with his supervisors Prof. Marcelo Sternberg of the ...
Cached Biology News:Built-in 'self-destruct timer' causes ultimate death of messenger RNA in cells 2Built-in 'self-destruct timer' causes ultimate death of messenger RNA in cells 3Reclaiming the land after a forest fire 2
(Date:12/24/2014)... GMO corn cases filed across the ... in the process of being consolidated in a Kansas ... In Re: Syngenta AG MIR 162 Corn Litigation, MDL ... District of Kansas. , Management of the Syngenta GMO ... U.S. District Judge John W. Lungstrum.* , As a ...
(Date:12/24/2014)... According to Ross Selinger, President of ... Global, the national office market continues to be strong, driven ... evidenced by the third quarter’s surprising 3.9% GDP, unemployment decreasing ... costs have held inflation down and the Fed is keeping ... market remaining soft. , This solid economic news is having ...
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... their #HolidayInTheLab pictures for a chance to win pipette-themed ... those struggling to think of a holiday gift for ... Lab Contest provides the ideal holiday presents. The #HolidayInTheLab ... pictures of their chemistree, holiday sweaters, as well as ...
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich Corporation ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements ... expired on December 22, 2014, thereby completing the ... for the acquisition of the Company by Merck ... clearance satisfies another condition to closing the transaction, ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3
... BALTIMORE, March 7, 2011 Champions Biotechnology, Inc. (OTC: CSBR), ... ended January 31, 2011. Fiscal 2011 Third ... of $2,805,000 representing an increase of 278% compared to the ... ($415,000); Net income excluding stock based compensation of $796,000* ...
... a sheet of carbon atoms linked in a ... microelectronics. Only one atom thick and highly conductive, graphene ... smaller, faster and more energy-efficient. In addition ... bio devices and gas molecule sensors, the material has ...
... Dynamics International (CDI), the world,s largest producer of ... today announced the publication of research demonstrating an efficient ... induced pluripotent stem cells (iPSCs) under a feeder-free condition ... 1 in PLoS ONE , will likely be ...
Cached Biology Technology:Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 4Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 5Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 6Probing atomic chicken wire 2Probing atomic chicken wire 3Probing atomic chicken wire 4Cellular Dynamics International Scientists Report on Efficient Method to Produce Footprint-Free Induced Pluripotent Stem Cells (iPSCs) Under Feeder-Free Conditions 2Cellular Dynamics International Scientists Report on Efficient Method to Produce Footprint-Free Induced Pluripotent Stem Cells (iPSCs) Under Feeder-Free Conditions 3
... is a base medium for preparation of minimal ... sulfate but does not contain amino acids. Both ... Each pouch contains reagents to prepare 500 ml ... ml of 10X YNB for S. cerevisiae media. ...
... of the family of human cullin genes (CUL-1, -2, ... cerevisiae cdc53 gene. Cullin-3 is proposed to be a ... complex with cyclin E and targets it for ubiquitination, ... is an activator of cdk2, which leads the cell ...
Imject Freund's Incomplete Adjuvant (FIA)...
With sodium bicarbonate. Sterile, Cell culture tested...
Biology Products: