Navigation Links
Gene therapy a step closer to mass production
Date:6/24/2010

EUREKA project E! 3371 Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells. These new agents, derivatives of cationic amphiphilic 1,4-dihydropyridine (1,4-DHP), avoid the problems of the recipient's immune system reacting against a viral carrier. The project partners have developed methods to produce them in large amounts, which solves another of the problems with viral delivery. But the greatest advantage is that the new compounds are significantly more effective at delivering DNA into cell nuclei than other standard synthetic carriers; increasing the chance of the DNA successfully controlling the defective genes, and the disease.

Gene therapy involves the insertion of DNA into human cells within the body to treat disease. The technique is still in its early days, and has been demonstrated successfully only in the last decade. Most investigation has been into the possibilities for treating hereditary diseases related to a genetic defect, and the technique also has potential uses in treating the early stages of cancer, and in cardiovascular and neurodegenerative diseases.

Gene therapy faces many difficulties as a practical method; not the least of which is that DNA is a large and complicated structure which needs to be delivered and attached to the correct section of the recipient's set of DNA. A number of methods are in use or under investigation for introducing DNA into cells (a process known as transfection) using viruses, chemical agents or physical injection.

Viruses or chemical carriers

With viral carriers, the DNA to be introduced is injected into the virus, which carries it into the cell by way of a vesicle formed around the virus particle by the cell wall. Once inside the cell, the vesicle breaks down and the virus injects the DNA into the cell's nucleus. The viral route does, however, have major disadvanta
'/>"/>

Contact: Piotr Pogorzelski
piotr.pogorzelski@eurekanetwork.org
322-777-0979
EUREKA
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UF oncologists fight leukemia with two-pronged therapy, clinical trials planned
2. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
3. Making personalized lung cancer therapy a reality in Europe
4. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
5. 4-D software helps adjust for breathing when treating lung cancer with radiotherapy
6. Tool allows precise targeting of radiotherapy for cancer radiation therapy
7. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
8. Smoking during radiation therapy for head and neck cancers linked to poorer outcomes
9. JDRF partners with LCT to test encapsulated cell replacement therapy for the treatment of diabetes
10. Concord Medical Enters Agreement to Acquire Four Radiotherapy and Diagnostic Imaging Centers in Hebei Province
11. Lengthening time a drug remains bound to a target may lead to improving diagnostics, therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene therapy a step closer to mass production
(Date:8/20/2014)... State University, the Wellcome Trust Sanger Institute and the ... Mycobacterium pinnipedii from skeletons found in Peru ... is a relative of the TB bacterium that affects ... These researchers assume that seals carried the pathogens from ... lions was unexpected" comments Sebastien Gagneux, from the Swiss ...
(Date:8/20/2014)... Health has awarded the Oklahoma Medical Research Foundation a ... anthrax and the bacteria,s effects on humans. , ... his colleagues have studied the human immune response to ... Human Immunology. The original funding came soon after anthrax-laced ... of the terrorist attacks of Sept. 11, 2001. ...
(Date:8/20/2014)... spiciness that is irresistible to some, but intolerable to ... their findings to develop a new drug candidate for ... inflammation or other problems. They reported their progress on ... in ACS, Journal of Medicinal Chemistry . , ... had pegged a compound called capsaicin as the active ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2
... release is available in German . ... been awarded this year,s Heinz Maier-Leibnitz Prizes. The relevant ... Germany,s most prestigious award for young scientists. The prizewinners ... Hanover, Dr. Wilhelm Hofmann, Psychology, University of Wrzburg, Dr. ...
... triggered by environmental stimuli and often occur in response to ... predisposition to develop these diseases, which highlights a role for ... high number of people with depression have a genetic change ... each other in the brain. Imaging of people with ...
... Williams boards ferries bound for North Carolina,s Outer Banks, the ... her the "Pollen Lady." Each spring from 2006 ... to the mainland, collecting pine pollen blown far offshore. She ... the most commonly planted tree in the southern United ...
Cached Biology News:Heinz Maier-Leibnitz Prizes 2010: 6 outstanding young researchers honored 2Heinz Maier-Leibnitz Prizes 2010: 6 outstanding young researchers honored 3Heinz Maier-Leibnitz Prizes 2010: 6 outstanding young researchers honored 4Depression associated with sustained brain signals 2Gone with the wind: Far-flung pine pollen still potent miles from the tree 2
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
(Date:8/20/2014)... 2014 Not long ago, it was ... be performed late in the development cycle – even ... regulatory trends suggest that, like many things GxP, expectations ... recent years, multiple drug sponsors have been required by ... questions during phase I/II. It’s not only clinical trial ...
(Date:8/20/2014)... 2014 GraphDB™ 6.0 ... improvements to the enterprise replication cluster, faster loading ... SOLR and Elasticsearch. This release happens to coincide ... triplestore – GraphDB™ was formerly known as OWLIM. ... only mature enterprise resilient RDF triplestore will also ...
(Date:8/19/2014)... 2014 A Geisinger researcher on a personal ... Centers for Disease Control and Prevention (CDC) award recognizing ... concern. Joseph Boscarino , Ph.D. MPH, ... team of researchers nominated for the Centers for Disease ... for Data Methods and Study Design. "Hepatitis ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... , ... WX ), a,leading pharmaceutical, biotechnology, and medical-device research ... United States,announced that it had been selected to the ... consecutive year. The list recognizes the 50,fastest-growing companies in ...
... , DURHAM, N.C., Nov. 27 ... water-soluble carbon nanotube-based cancer drug delivery system in Hyderabad, India. ... walls that allows for conjugation with cancer drugs, was developed ... conjugated carbon nanotubes serves as a drug delivery vehicle with ...
... , BOSTON, Nov. 25 Biotech firm Replikins Ltd., ... pandemic through the prediction, outbreak, and progress of the current H1N1 ... new data shows that the lethality of the H1N1 ("Swine Flu") ... the virus,s current outbreak in the spring of 2009 to resting ...
Cached Biology Technology:WuXi PharmaTech Named in Deloitte Technology Fast 50 China 2009 List for the Fifth Consecutive Year 2North Carolina Based Cromoz Inc. Launches Carbon Nanotechnology for Target Drug Delivery System in Cancer Treatment in Hyderabad, India 2Biological H1N1 Vaccines: Too Little, Too Late 2Biological H1N1 Vaccines: Too Little, Too Late 3Biological H1N1 Vaccines: Too Little, Too Late 4Biological H1N1 Vaccines: Too Little, Too Late 5
... isolated fromStreptomyces griseolusthat inhibits protein synthesis. ... in eukaryote ribosomes. Reported to induce ... including promyelocytic leukemia cells, Jurkat cells, ... Initiates intracellular signals and immediate early ...
... RC DC protein assay kit I provides reagents ... in the presence of reducing agents and detergents. ... assay. The kit includes reagents and standards sufficient ... I, 250 ml RC reagent II, 250 ml ...
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
... state-of-the-art separation system using the asymmetric flow ... integrates easily with Wyatts multi-angle light scattering ... as the Optilab DSP. The combined system ... of the particles/molecules separated by the AFFF ...
Biology Products: