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Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine
Date:10/8/2007

the 2001 Albert Lasker Award for Basic Medical Research and the 2001 National Medal of Science, Americas highest award for lifetime achievement in scientific research, presented by President George W. Bush. In 2003, he also received the Wolf Prize in Medicine, Israels highest award for medical science, and the 2003 Pezcoller Foundation-AACR (American Association for Cancer Research) International Award for Cancer Research. Capecchi also received the 2005 March of Dimes Prize in Developmental Biology.

The University of Utah proudly joins the Nobel Foundation and the entire international scientific community in congratulating Mario Capecchi on his outstanding scientific achievements, said University of Utah President Michael K. Young. His accomplishments are particularly remarkable in light of the tremendous challenges he faced in his youth. He has drawn upon these life experiences to propel himself into doing the most extraordinary thingsultimately enabling people across the globe to live healthier, longer, and more productive lives. Mario Capecchis groundbreaking work in gene targeting will have an incalculable impact on generations to come. We are deeply honored and grateful that he is one of ours.

Capecchis development of gene targeting in mouse embryo-derived stem cells allows investigators to create mice with mutations in any desired gene and gives them virtually complete freedom to manipulate the DNA sequences in the genome of living mice. Knockout technology makes possible detailed evaluation of the function of every mouse gene at any stage of development or in the adult. The technology not only has made possible the production of animal models for human disease, but it also is providing Capecchi and other researchers with insights into understanding fundamental biological questions, including development of the brain in the embryo or its function in the adult.

Capecchi was born in Verona, Italy, in 1937. His mother was impri
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Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences Center
Source:Eurekalert

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