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Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome
Date:1/18/2009

we see in cancer are leading cells to look and behave like other cells they're not at all supposed to be like," Feinberg says. "For example, colon cells that become cancerous might start to act like brain, liver or spleen cells. They're losing the characteristics they should have and taking on those of other tissues."

He and his colleagues suggest in the study, published online on Jan. 18 in Nature Genetics, that their newly developed map of where these methylation sites differ in colon cancer and healthy tissue may eventually help researchers develop treatments for cancer by restoring normal methylation patterns or by targeting the gene pathways they have identified in this study.


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Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

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