Navigation Links
Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome
Date:1/18/2009

erg School of Public Health, and their colleagues wondered whether undiscovered methylated sites were hiding unnoticed elsewhere in the genome. The researchers performed their comprehensive survey in human brain, liver and spleen tissues obtained from five autopsies, identifying 16,379 methylated regions using a new method that searches all DNA, not just CpG islands.

To their surprise, the researchers discovered that about 76 percent of the genome's methylated sites occur a short distance away from the islands, between 200 and 2,000 kilobases away. In contrast, only 6 percent of methylated sites were situated inside CpG islands. Because of the newly discovered sites' proximity to the islands, the researchers named them CpG shores.

"This finding is so unexpected because CpG islands are the areas where scientists have really concentrated their research," Feinberg says.

Taking their research a step further, Feinberg, Irizarri and their colleagues searched for new methylated areas in colon tumors as well as normal colon tissue removed from 13 different cancer patients. The researchers identified 2,707 regions in both CpG islands and shores that were either more or less methylated between the two tissue types. Previous studies by other research groups, looking only at CpG islands, have suggested that the DNA in cancer cells tends to be more methylated compared to normal, healthy cells. However, comparing the tumor and healthy colon cells' entire genomes, including CpG islands as well as shores, Feinberg's group found that cancer cells had a roughly equal number of more-methylated and less-methylated sites than the normal cells.

When the researchers looked at where these differently methylated sites were located in the cancer cells, they found that these regions matched up with many of the methylated areas they'd located in the normal brain, liver and spleen tissues they had examined.

"This suggests that the epigenetic changes
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Growth of new brain cells requires epigenetic switch
2. Burnham researchers discover on switch for cell death signaling mechanism
3. How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
4. Researchers find natures shut-off switch for cellulose production
5. Women double fruit, veggie intake with switch to Mediterranean diet plan
6. New master switch found in the brain that regulates appetite and reproduction
7. Newly discovered molecular switch helps decide cell type in early embryo development
8. Miscanthus can meet US biofuels goal using less land than corn or switchgrass
9. Control switches found for immune cells that fight cancer, viral infection
10. A molecular switch turns on the flame in natures blowtorch
11. Berkeley researchers identify photosynthetic dimmer switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... Catching a football. Maneuvering through a room full of ... fore. Most would agree these seemingly simple actions require us ... of Cognitive Science at Rensselaer Polytechnic Institute Mark Changizi argues ... It takes our brain nearly one-tenth of a second to ...
... hold empirical knowledge that tuna aggregate under floating objects, ... or even large marine mammals. There is still no ... 20 years have seen purse-seine fishery operators take advantage ... floating rafts equipped with buoys which act as FADs. ...
... in green tea may be able to stave off ... (OSA), according to a new study published in the ... American Journal of Respiratory and Critical Care Medicine. ... through drinking water, on rats who were intermittently deprived ...
Cached Biology News:Crystal (eye) ball: Study says visual system equipped with 'future seeing powers' 2Crystal (eye) ball: Study says visual system equipped with 'future seeing powers' 3Does fishing on drifting fish aggregation devices endanger the survival of tropical tuna? 2Does fishing on drifting fish aggregation devices endanger the survival of tropical tuna? 3Green tea compounds beat OSA-related brain deficits 2
(Date:5/4/2015)... --  Intrexon Corporation (NYSE: XON ) today ... after the market closes on May 11, 2015.  The ... 5:30 PM ET to discuss the results and provide ... may be accessed by dialing 1-888-346-3959 (Domestic US) and ... Call."  Participants may also access the live webcast through ...
(Date:5/1/2015)... - BioAmber Inc. (NYSE: BIOA ), an industrial ... priced an underwritten registered offering of 3,900,000 shares of ... share, and granted the underwriters in the offering a ... shares of its common stock. The gross proceeds to ... to close on May 6, 2015, subject to customary ...
(Date:5/1/2015)... ALBANY, N.Y. , May 1, 2015 ... today that William S. Marth , AMRI,s President ... of America Merrill Lynch 2015 Health Care Conference on ... A live audio webcast of the presentation can ... http://ir.amriglobal.com/events.cfm?CalendarID=2          The webcast will be ...
(Date:4/30/2015)... , April 30, 2015   Tamir Biotechnology , ... an update on its Ebola antiviral therapy program. ... candidates, TMR004, is currently being evaluated and considered by ... battle against Ebola. During the first quarter of 2015, ... Meeting To Accelerate The Evaluation of Potential Treatments and ...
Breaking Biology Technology:Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 3AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4
... Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: IMDS), ... I returned to the company three months ago to,assume ... Board; we have,received many phone calls from our shareholders ... my first priority, I have,recently secured a tiered debenture ...
... Conn., Aug. 5 Marinus Pharmaceuticals, a,developer of ... disorders, has appointed John Krayacich as president,and chief ... leading,the company,s drug and business development for ganaxolone, ... and chelerythrine, a pre-clinical,schizophrenia candidate., Mr. Krayacich ...
... Group, P.A., Deliver Faster Recovery,Fewer Complications for ... Aug. 5 Thoracic Group, P.A., (http://www.thoracicgroup.com ... services,and a national leader of minimally-invasive video ... completion of its 5,000th VATS,surgical procedure. Highly ...
Cached Biology Technology:CEO's Letter to Shareholders of Imaging Diagnostic Systems, Inc. 2CEO's Letter to Shareholders of Imaging Diagnostic Systems, Inc. 3CEO's Letter to Shareholders of Imaging Diagnostic Systems, Inc. 4Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 2Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 3Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 4Renowned NJ-Based Video Assisted Thoracic Surgery (VATS) Team Completes 5,000th Successful Procedure 2Renowned NJ-Based Video Assisted Thoracic Surgery (VATS) Team Completes 5,000th Successful Procedure 3
... PCR System is the only PCR system ... and every time. It provides accuracy, consistency, ... source or the property of the DNA ... Enzyme Mix, a unique blend of thermostable ...
ID clarifier: With ethidium bromide (50 μg/ml)...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... Buffer is a convenient, premixed, ... samples and Perfect RNA Markers. ... no dilution and is suitable ... Simply mix equal volumes of ...
Biology Products: