Navigation Links
Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome
Date:1/18/2009

Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named "shores."

"Our study suggests that the real jackpot for methylation isn't where we have all been looking, but in these shores located just nearby," says Andrew Feinberg, M.D., M.P.H., professor of medicine at the Johns Hopkins University School of Medicine.

Feinberg explains that the discovery is more than academic since it may shift the current focus away from the islands to thousands of new sites scattered throughout the genome, each with the potential to serve as novel targets for studying the development of tissues, organs and animals, and for treating diseases such as cancer already known to involve methylation chemistry.

Methylation is one of several so-called epigenetic modifications that affect which genes are expressed without changing the DNA sequence itself. Previous studies have suggested that DNA methylation plays an important role in guiding stem cells to mature into a variety of cell types such as hair, muscle and nerve cells. Methylation has also been implicated in the abnormal gene expression that cancer cells show.

The long-time focus in methylation has been CpG islands, regions of the genome rich in the DNA building-block molecules cytosine and guanine. The reason is that these islands tend to occur near the "start" signal of a protein-coding gene, a place with the potential to affect whether that gene is expressed or not and to what extent.

However, Feinberg and co-investigator Rafael I. Irizarri, Ph.D., of the Johns Hopkins University Bloomb
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Growth of new brain cells requires epigenetic switch
2. Burnham researchers discover on switch for cell death signaling mechanism
3. How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
4. Researchers find natures shut-off switch for cellulose production
5. Women double fruit, veggie intake with switch to Mediterranean diet plan
6. New master switch found in the brain that regulates appetite and reproduction
7. Newly discovered molecular switch helps decide cell type in early embryo development
8. Miscanthus can meet US biofuels goal using less land than corn or switchgrass
9. Control switches found for immune cells that fight cancer, viral infection
10. A molecular switch turns on the flame in natures blowtorch
11. Berkeley researchers identify photosynthetic dimmer switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... 18, 2007For unknown reasons a protein called amyloid beta aggregates ... are one of the hallmarks of Alzheimers disease. Now two ... deadly transformation of amyloid beta into plaques can be prevented ... cystatin C. Although much work needs to be done, ...
... Blacksburg, Va. In support of the Asia-Pacific Partnership ... State has awarded more than $1 million to a ... Technologies at Virginia Tech to help India increase energy ... by developing and testing advanced technologies for cleaning coal. ...
... A new NASA study estimates that most ground-level particulate ... in North America and only a small amount is ... world. Researchers using an innovative global aerosol tracking ... estimate of sources and movements of aerosols near the ...
Cached Biology News:A novel way found to prevent protein plaques implicated in Alzheimer's 2A novel way found to prevent protein plaques implicated in Alzheimer's 3University-industry team developing coal cleaning technology in India 2University-industry team developing coal cleaning technology in India 3Local sources major cause of US near-ground aerosol pollution 2
(Date:12/24/2014)... December 23, 2014 Nashville Fertility Center ... elected treasurer for the American Society for Reproductive Medicine ... and research in reproductive medicine. In his new ... on the executive board and will have a voice ... Hill has actively supported ASRM since 1984 when he ...
(Date:12/24/2014)... BEIJING , Dec. 23, 2014 ... or the "Company"), a leading fully integrated plasma-based ... today announced that its majority-owned subsidiary, Shandong Taibang ... Practices ("GMP") certification from the China Food and ... factor production facility. As previously disclosed in the ...
(Date:12/24/2014)... Dec. 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... on December 22, 2014, thereby completing the U.S. ... the acquisition of the Company by Merck KGaA, ... satisfies another condition to closing the transaction, which ...
(Date:12/22/2014)... & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across the ... for Clinical Data Management (SCDM) to provide the ... certification programs —providing access to the more than ... extends SCDM members with 10% off when registering for ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... BC, Sept. 5 /PRNewswire/ - GenoLogics, ... management software solutions for life sciences ... the Affymetrix,GeneChip-compatible(TM) Applications Program, and its ... the Affymetrix, Inc. (Nasdaq:,AFFX) GeneChip(R) microarray ...
... and process labs and ... offer practical compliance solutions, ST. LOUIS, Sept. 5 ... present a Web,conference on laboratory compliance strategies on September 19, ... U.S. federal laws,pertaining to the research and process laboratories and ...
... A study in the August 2007,issue ... the GlycoMark,1,5-anhydroglucitol (1,5-AG) blood test to evaluate ... postprandial hyperglycemia (elevated,after-meal glucose levels). Controlling after-meal ... control and reducing the burden of,cardiovascular complications, ...
Cached Biology Technology:GenoLogics' Geneus Achieves GeneChip-compatible(TM) Status with the Affymetrix GeneChip(R) Microarray Platform 2GenoLogics' Geneus Achieves GeneChip-compatible(TM) Status with the Affymetrix GeneChip(R) Microarray Platform 3Sigma-Aldrich and Lab Manager Magazine Present Webinar On Laboratory Environmental, Health and Safety Compliance Strategies 2Sigma-Aldrich and Lab Manager Magazine Present Webinar On Laboratory Environmental, Health and Safety Compliance Strategies 3Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes 2
Control primers and template for 5kb and 15 kb products....
Carrier Serum...
The Lambda Control Kit contains lambda DNA and two 25mer primers, which can be used to amplify a 500bp fragment. The lambda DNA is purified by CsCl gradient centrifugation and organic extraction foll...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Biology Products: