Navigation Links
Gene switch for odorant receptors
Date:11/11/2011

ber of receptor molecules produced by an individual cell. It works, therefore, like an on-off switch," says Peter Mombaerts from the Max Planck Institute of Biophysics. The P element does not influence genes from other clusters on the same or on other chromosomes.

The engineered loss of the P element has different effects on the choice of odorant receptor genes: some genes are no longer chosen, others are chosen by fewer olfactory sensory neurons, and some genes remain completely unaffected by the absence of the P element. Thus the P element is not the only DNA sequence that regulates gene choice within this cluster of 24 genes. This is also indicated by the limited "reach" of the regulatory elements: the effect of the H and P elements is restricted to 200,000 base pairs. "We can estimate from the number of odorant receptor genes and the average distance between these genes the potential number of regulatory elements. Each cluster is controlled by several elements. We speculate that there may be as many as 150 such regulatory elements for odorant receptor gene choice in the mouse genome," explains Mombaerts.

The scientists do not yet know how these elements regulate the choice of an odorant receptor gene within a cluster. It is possible that regulatory proteins dock to special binding sites on the DNA.

This discovery was made possible by the new method "NanoString" for measuring RNA levels in tissues. The Max Planck researchers were able to measure the levels of messenger RNA for half of all the odorant receptor genes in one go. With traditional methods, the RNA level could be analysed for only one odorant receptor gene at a time.

These findings have taken the scientists one step closer to figuring out how an olfactory sensory neuron selects one of 1200 genes for expression. "We still have a long way to go in solving this fascinating mystery. The arrangement in clusters may play a role. It is clear that this process does not ju
'/>"/>

Contact: Peter Mombaerts, M.D., Ph.D.
peter@mombaerts.org
49-696-303-4000
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. For deep-sea cephalopods, switchable camouflage saves the day
2. Novel technique switches triple-negative breast cancer cells to hormone-receptor positive cells
3. Switching senses
4. Faulty molecular switch can cause infertility or miscarriage
5. Discovery of insulin switches in pancreas could lead to new diabetes drugs
6. Protein switches could turn cancer cells into tiny chemotherapy factories
7. Researchers discover a switch that controls stem cell pluripotency
8. Outsmarting algae -- RIT scientist finds the turn-off switch
9. TUM researchers discover a new switch in resistance to plant diseases
10. Switch from corn to grass would raise ethanol output, cut emissions
11. Genetic switch for limbs and digits found in ancient fish
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene switch for odorant receptors
(Date:9/18/2014)... Mass. A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... starts a "frequent flyers" program, fruit flies surely would ... has hosted increasing numbers of fruit fly research studies. ... in April, and another is scheduled launch to the ... launch in December. , Fruit flies are biomedical research ... space. Model organisms can reveal the basis for health ...
(Date:9/18/2014)... foliage season that prompts millions of Americans to undertake jaunts ... possibly last a little longer within a century, according to ... in some areas of the United States as summer temperatures ... the journal Global Ecology and Biogeography . For instance, ... the state tree of New Hampshire could change color ...
Breaking Biology News(10 mins):Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... PARK, Md. There,s no "silver bullet" for ... policies, but they do need reforming, says University ... testified today before the Senate Armed Services Committee. ... operation during the Clinton administration and has served ...
... one in 3,500 people are affected with retinitis pigmentosa ... eventually leads to blindness. Now, a University of Missouri ... humans for two different forms of RP. This discovery ... both cats and humans. "The ...
... of our bodies, could lead to remarkable advances in the ... organised by the European Science Foundation was told. The ... in Granada, Spain, on 23 February 2009, was part of ... research in Europe in recognition of the potential of RNA ...
Cached Biology News:Reforming defense department acquisition policy: UM expert 2Cats' eye diseases genetically linked to diseases in humans 2RNA research strategy for Europe takes shape 2
(Date:9/18/2014)...   Sigma-Aldrich Corporation (Nasdaq: ... a new gene editing partnership with the University ... the partnership, Sigma-Aldrich will provide the Vector Core ... dedicated gene editing bioinformaticians. The partnership ... the U-M Medical School. One initiative already underway, ...
(Date:9/18/2014)... expensive. Now a team led by an engineer at ... designs that will let scientists slash the cost of ... , Syringe pumps are used to dispatch precise amounts ... in a reaction. They can also cost hundreds or ... team of Michigan Tech students published the library of ...
(Date:9/18/2014)... computing may have just taken an encouraging step forward. ... by chemist Stephen O,Brien have discovered new complex oxides ... both properties is very exciting scientifically for the coupling ... that might ultimately be designed, in logic circuits or ... however, has proved difficult until now. , Using an ...
(Date:9/18/2014)... 2014 Whitehouse Laboratories is pleased to ... Group and has acquired an additional 4,000 square feet ... Executive Complex adjacent to its current package testing facility. ... September 5th. Whitehouse Labs is in the process of ... for package testing. The prime location enables Whitehouse Labs ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Doing science just got cheaper -- and faster 2Oxides discovered by CCNY team could advance memory devices 2Whitehouse Labs Announces Package Testing Laboratory Expansion 2Whitehouse Labs Announces Package Testing Laboratory Expansion 3Whitehouse Labs Announces Package Testing Laboratory Expansion 4
... For low-throughput disruption of a wide range of biological samples , ... , , ... of biological samples, including animal,and human tissues and cells and plant tissue. , ... The TissueRuptor system provides: , ...
... , ... and easy silica-based DNA purification in convenient spin-column and 96-well-plate,formats. Most ... for mechanical disruption and reducing,hands-on time. Optimized protocols for specific sample ... veterinary pathogen research applications. , ...
... Tracy Worzella and Brad Larson , Promega Corporation, Madison, WI, USA ... Application Note 138 ... , , Correlated measurement of ... Monitoring of both luminescence and fluorescence output signals from , one assay ...
Cached Biology Technology:TissueRuptor System 2TissueRuptor System 3DNA purification from pig ears to bird blood using proven DNeasy Technology 2Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar 2Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar 3Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar 4Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar 5
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Mouse monoclonal [CIa] to Ia Antigen (Biotin) ( Abpromise for all tested applications)....
Goat polyclonal to FBXO2 ( Abpromise for all tested applications). entrezGeneID: 26232 SwissProtID: Q9UK22...
Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
Biology Products: