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Gene site found for children's food allergy
Date:3/7/2010

(CHOP). They then replicated the initial findings with additional DNA samples from EoE patients and controls at CHOP. The gene studies pointed to chromosome 5q22.1, which contains the TSLP gene. TLSP holds the genetic code to produce a cytokine, a specific signaling protein that regulates inflammatory responses occurring in allergic diseases.

Because children with EoE are often allergic to many foods, they may be limited to an elemental formula containing no large food proteins, to allow time for their symptoms to resolve. Physicians then perform tests to determine which foods a child can or cannot eat.

"Eosinophilic esophagitis is a highly allergic disease, and one that is rapidly expanding," said allergist Jonathan M. Spergel, M.D., a co-first author of the study, who sees large numbers of patients with EoE as director of the Center for Pediatric Eosinophilic Disorders at The Children's Hospital of Philadelphia. "This is the first genome-wide association study done on this disease, and now that we have elucidated a gene pathway, the hope is that physicians can eventually intervene in that pathway and discover a new treatment."


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Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

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