Navigation Links
Gene site found for children's food allergy
Date:3/7/2010

Pediatrics researchers have identified the first major gene location responsible for a severe, often painful type of food allergy called eosinophilic esophagitis (EoE). In this disease, which may cause weight loss, vomiting, heartburn and swallowing difficulties, a patient may be unable to eat a wide variety of foods.

After performing a genome-wide association study, the study team found EoE was linked to a region of chromosome 5 that includes two genes. The likely culprit is the gene TSLP, which has higher activity levels in children with EoE compared to healthy subjects. In addition, TSLP has been previously linked to allergic inflammatory diseases, such as asthma and the skin inflammation, atopic dermatitis.

"This gene is a plausible candidate because of its biological role in allergic inflammation," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia. Hakonarson and colleagues collaborated with Marc E. Rothenberg, M.D., Ph.D., director of the Center for Eosinophilic Disorders at the Cincinnati Children's Hospital Medical Center.

The study appears online today in Nature Genetics.

Only recently recognized as a distinct condition, EoE, like other allergies, has been increasing over the past 20 years, and its reported incidence of one in 10,000 people may be an underestimate. The hallmark of EoE is swelling and inflammation in the esophagus, accompanied by high levels of immune cells called eosinophils. It can affect people of any age, but is more common among young men who have a history of other allergic diseases such as asthma and eczema. EoE is often first discovered in children with feeding difficulties and failure to thrive.

In the current study, the researchers performed a genome-wide analysis on 181 samples from the Cincinnati center, compared to nearly 2,000 healthy controls from The Children's Hospital of Philadelphia
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Chicago and Ataxia Foundation team up for annual scientific and patient meetings
2. Modern man found to be generally monogamous, moderately polygamous
3. Key player found for a cancer typical in Down syndrome
4. Rockefeller Foundation supports expansion, training of e-health work force in developing world
5. Lymphoma Research Foundation announces publication of Mantle Cell report
6. Anorexics found to have excess fat-- in their bone marrow
7. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
8. Peter Reich, BBVA Foundation Frontiers of Knowledge Award in Ecology
9. Deadly fish virus now found in all Great Lakes
10. Genes found linked to breast cancer drug resistance could guide future treatment choices
11. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... Jos Zanchetta, a member of the IOF Board and ... has been named the recipient of the prestigious Pierre ... Osteoporosis Foundation (IOF) in memory of Pierre D. Delmas, ... growth of the Foundation and osteoporosis advocacy worldwide. ...
... the damage caused by a heart attack survived in the ... a mouse model, researchers at The University of Texas MD ... Circulation Research . The study, with researchers at the ... imaging techniques developed by researchers at MD Anderson to track ...
... a 1600 km-wide ash cloud over the Atlantic. The ... visible in stark contrast to white clouds framing this ... emitting steam and ash on 20 March, wreaking havoc ... week caused some flights to be suspended to and ...
Cached Biology News:Transplanted adult stem cells provide lasting help to injured hearts 2Transplanted adult stem cells provide lasting help to injured hearts 3Transplanted adult stem cells provide lasting help to injured hearts 4
(Date:6/26/2015)... ... June 26, 2015 , ... ... that its SimplePrep™ technologies have been integrated into a sample prep module intended ... (ISS) as a part of the NASA’s WetLab-2 Project. , On June 28, ...
(Date:6/25/2015)... 2015 Last June, a dedicated global team of ... using large-scale genome sequencing. Their research, which was written on ... journal Cell (Park 2015) , reveals critical ... months of the recent Ebola outbreak. Today Authorea ... workflows, and full edit history of the paper are ...
(Date:6/25/2015)... DIEGO , June 25, 2015  BioMed Realty ... Illumina, Inc. (NASDAQ: ILMN ), a world leader ... the power of the genome, has signed a 20-year ... scientific research building in Cambridge, England ... and access to the highly skilled workforce in the ...
(Date:6/25/2015)... Francisco, CA (PRWEB) , ... June 25, 2015 ... ... uBiome Studies Portal to support citizen science opportunities in microbiome research, on a ... a microbiome sequencing service that made history with a record-breaking campaign to sequence ...
Breaking Biology Technology:Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3Open Science Takes Major Leap Forward 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 3uBiome Launches Studies Portal to Support Microbiome Research 2uBiome Launches Studies Portal to Support Microbiome Research 3
... Companies will Present at the Largest Marketplace for Emerging ... and CTSI today announced that more than 100 leading ... partners will be showcased in the 4th Annual TechConnect ... R. Brown Convention Center in Houston, Texas. Held ...
... Development and InnovationMOUNTAIN VIEW, Calif., April 22 ... Pharmaceuticals & Biotechnology group assesses a variety of ... in cancer treatment. Physicians, nurses and patients ... reconstitution, home vs. office administration parameters, and barriers ...
... 22 GeneGo, Inc., a leading provider of software ... , today announced that the University of Cardiff has ... researchers will have access to GeneGo,s MetaCore, training and ... their partner relationship with GeneGo to provide a pathway ...
Cached Biology Technology:TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 2TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 3TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 4Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 2Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 3Cardiff University Becomes a GeneGo Center of Excellence 2
...
cysteine and glycine-rich protein 2,...
... agent and DNA-topoisomersae II inhibitor (IC50 = 59.2 ... C 29 H 32 O 13 ... Store at: RT ... Soluble to 100 mM ...
HSPBP1 Antibody...
Biology Products: