Navigation Links
Gene-silencing study finds new targets for Parkinson's disease
Date:11/24/2013

rge of NIH's RNAi facility. The RNAi group used robotics to introduce small interfering RNAs (siRNAs) into human cells to individually turn off nearly 22,000 genes. They then used automated microscopy to examine how silencing each gene affected the ability of parkin to tag mitochondria.

"One of NCATS' goals is to develop, leverage and improve innovative technologies, such as RNAi screening, which is used in collaborations across NIH to increase our knowledge of gene function in the context of human disease," said Dr. Martin.

For this study, the researchers used RNAi to screen human cells to identify genes that help parkin tag damaged mitochondria. They found that at least four genes, called TOMM7, HSPAI1L, BAG4 and SIAH3, may act as helpers. Turning off some genes, such as TOMM7 and HSPAI1L, inhibited parkin tagging whereas switching off other genes, including BAG4 and SIAH3, enhanced tagging. Previous studies showed that many of the genes encode proteins that are found in mitochondria or help regulate a process called ubiquitination, which controls protein levels in cells.

Next the researchers tested one of the genes in human nerve cells. The researchers used a process called induced pluripotent stem cell technology to create the cells from human skin. Turning off the TOMM7 gene in nerve cells also appeared to inhibit tagging of mitochondria. Further experiments supported the idea that these genes may be new targets for treating neurological disorders.

"These genes work like quality control agents in a variety of cell types, including neurons," said Dr. Youle. "The identification of these helper genes provides the research community with new information that may improve our understanding of Parkinson's disease and other neurological disorders."

The RNAi screening data from this study are available in NIH's public database, PubChem, which any researcher may analyze for additional information about the role of dysf
'/>"/>

Contact: Christopher G Thomas
thomaschr@ninds.nih.gov
301-435-2264
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New genomic study provides a glimpse of how whales could adapt to ocean
2. Study finds gene network associated with alcohol dependence
3. A study on cell migration provides insights into the movement of cancer cells
4. UT Dallas study: Initial success for new tinnitus treatment
5. Connections in the brains of young children strengthen during sleep, CU-Boulder study finds
6. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
7. Dartmouth-led study shows diet alone can be significant source of arsenic
8. Shadehouses with photoselective nets featured in study of growing conditions
9. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
10. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
11. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene-silencing study finds new targets for Parkinson's disease
(Date:9/1/2014)... An increasing amount of research shows an association between ... sedentary lifestyle. Now, a new Cornell University study points ... programs might lead people to eat twice as much ... an action movie while snacking your mouth will see ... on the new article just published in the ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
(Date:9/1/2014)... The quality of the U.S. diet showed some modest ... of a reduction in the consumption of unhealthy trans ... between the rich and the poor. , , An ... and some cancers. Eating a healthy diet is an ... outcomes. Evaluating population trends in diet quality is important ...
Breaking Biology News(10 mins):Can action movies make you fat? 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3
... a Global Information System will provide valuable information for ... Institute of Environmental Health Sciences (NIEHS), one of the ... the most up-to-date data to public health and safety ... maps, as well as demographic information for local populations. ...
... Some 12.3 percent of all babies -- 499,008 infants -- ... according to the report released by the National Center for ... 480,000 babies) in 2002 -- and an increase of more ... in 1981. The prematurity rate was 9.4 in 1981; it ...
... the world's vaccine manufacturers will be in a race ... a new technique to more efficiently produce the disarmed ... vaccine in large quantities, life-saving inoculations may be available ... as governments worldwide prepare for a predicted pandemic of ...
Cached Biology News:NIEHS launches website with information for assessing environmental hazards from Hurricane Katrina 2UW scientists report a new method to speed bird flu vaccine production 2UW scientists report a new method to speed bird flu vaccine production 3
(Date:9/1/2014)... , Sept. 1, 2014 Reportlinker.com announces ... in its catalogue: India Solid Waste ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In ... the main governing bodies responsible for complete handling ... On an average, around 135,000 MT solid waste ...
(Date:9/1/2014)... The global oligonucleotide synthesis market is expected ... million in 2014, growing at a CAGR of ... synthesis market is categorized on the basis of ... The synthesized oligonucleotides segment is expected to register ... market during the forecast period, owing to an ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... and Diagnostics report provides comprehensive understanding and unprecedented ... entered into by the worlds leading life science ... and analysis of how and why companies enter ... a prospective partner’s negotiated deals terms provides critical ...
(Date:8/31/2014)... 31, 2014 Wockhardt Limited today announces a ... Anti-Infective research when two of its drugs, WCK 771 ... Product (QIDP) status from U.S. Food & Drug Administration ... against pathogens which have a high degree of unmet ... for Disease Control (a top U.S. government health and ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 89.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3
... 2008 Diffusion,Pharmaceuticals LLC, a clinical-stage drug-development ... action that enhances,oxygen diffusion, today announced that ... entitled "Bipolar Trans Carotenoid Salts and Their ... of first-in-class new chemical entities,known as trans ...
... Mass., April 8, 2008 Caliper Life,Sciences, Inc. (Nasdaq: ... Meeting,of Stockholders will be held on June 3, 2008, ... 68 Elm Street, Hopkinton, Massachusetts. The record,date for Caliper ... 16,2008., About Caliper Life Sciences, Caliper Life ...
... pain reliever lands its first national retail drug ... ... ALCiS Health, Inc., a,provider of patented pain relief products, today announced ... cream, ALCiS Daily Relief, at all of its 6,237 stores.,Its introduction onto ...
Cached Biology Technology:Diffusion Pharmaceuticals Announces Issuance of U.S. Patent No. 7351844, Titled 'Bipolar Trans Carotenoid Salts and Their Uses,' for Its Family of First-In-Class Molecules 2ALCiS(R) Daily Relief Now Available at Walgreens 2
One-step, microplate or cuvet, colorimetric, linear detection range 0.7 mg/dL to 35 mg/dL. Procedure: 5 min....
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
Human DCIR/CLEC4A Phycoerythrin MAb (Clone 216110)...
Biology Products: