Navigation Links
Gene signature predicts oral cancer recurrence
Date:10/10/2011

Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death - largely due to the failure of current histological procedures in predicting the recurrence of the disease. New research published in BioMed Central's open access journal BMC Cancer shows that a four-gene signature may accurately predict which patients are at higher risk of OSCC recurrence.

A team of researchers, including Drs. Patricia Reis and Levi Waldron, and led by Dr Suzanne Kamel-Reid and Dr. Igor Jurisica, from the Ontario Cancer Institute at University Health Network (UHN) Toronto, Canada collected cancerous and noncancerous oral tissue samples from patients with OSCC from Toronto General Hospital at UHN. They then used a meta-analysis of five published microarray studies along with their own microarray analysis to reliably identify 138 genes commonly over-expressed in both OSCC and normal margin tissues. Of these genes, a four-gene signature with the highest predictive risk of recurrence was selected. This signature contained cell invasion related genes MMP1, COL4A1, P4HA2 and THBS2.

The researchers explained, "Our data suggest that histologically normal surgical resection margins that over-express MMP1, COL4A1, THBS2 and P4HA2 are indicative of an increased risk of recurrence in OSCC. Patients at higher risk of recurrence could potentially benefit from closer disease monitoring and/or adjuvant post-operative radiation treatment, even in the absence of other clinical and histopathological indicators. Our findings may be applied to develop a molecular test, which could be clinically useful to help predict which patients are at a higher risk of local recurrence."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. 2011 PerkinElmer Signature Genomic Laboratories Travel Award winner announced
2. Study identifies new genetic signatures of breast cancer drug resistance
3. Parascript SignatureXpert Wins Forensic Signature Verification Competition
4. CIC Announces Upcoming Webinar: Business Challenges & Technology Solutions in 2011: What Leading Insurance Carriers are Planning Now; eSignature Implications
5. Brain scans detect autisms signature
6. CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand
7. NIST mini-sensor traces faint magnetic signature of human heartbeat
8. Blood signatures to diagnose infection
9. Genome signatures enable tracking of algal complexity
10. Beverages leave geographic signatures that can track peoples movements
11. Genetic signatures provide new direction in liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/21/2016)... , March 22, 2016 ... with passcodes for superior security   ... leading provider of secure digital communications services, today announced ... technology and offer enterprise customers, particularly those in the ... recognition and voice authentication within a mobile app, alongside, ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Proove ... excited to announce the launch of the Proove Health Foundation . The ... education to promote the use of personalized medicine for tackling the nation’s most-pressing ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... fundamentals to transform technology into a viable company, CereScan’s CEO, John Kelley, joined ... Kelley, a recognized leader and mentor in the Denver area business community, shared ...
(Date:4/29/2016)... Elekta is pleased to announce ... industry-leading treatment planning software, is available for clinical release. ... version 5.11 provides significant performance speed enhancements over ... to four times faster than in previous versions of ... standard Monte Carlo algorithm, users ...
(Date:4/28/2016)... Rocky Hill, Conn. (PRWEB) , ... April 28, ... ... source of financing and ongoing support for Connecticut's innovative, growing companies, today announced ... early-stage digital health and financial technology (fintech) companies. , “VentureClash looks ...
Breaking Biology Technology: