Navigation Links
Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
Date:4/14/2013

The St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project has identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development.

The study focused on a family of brain tumors known as low-grade gliomas (LGGs). These slow-growing cancers are found in about 700 children annually in the U.S., making them the most common childhood tumors of the brain and spinal cord. For patients whose tumors cannot be surgically removed, the long-term outlook remains bleak due to complications from the disease and its ongoing treatment. Nationwide, surgery alone cures only about one-third of patients.

Using whole genome sequencing, researchers identified genetic alterations in two genes that occurred almost exclusively in a subtype of LGG termed diffuse LGG. This subtype cannot be cured surgically because the tumor cells invade the healthy brain. Together, the mutations accounted for 53 percent of the diffuse LGG in this study. Researchers also demonstrated that one of the mutations, which had not previously been linked to brain tumors, caused tumors when introduced into the glial brain cells of mice.

The findings appear in the April 14 advance online edition of the scientific journal Nature Genetics.

"This subtype of low-grade glioma can be a nasty chronic disease, yet prior to this study we knew almost nothing about its genetic alterations," said David Ellison, M.D., Ph.D., chair of the St. Jude Department of Pathology and the study's corresponding author. The first author is Jinghui Zhang, Ph.D., an associate member of the St. Jude Department of Computational Biology.

The Pediatric Cancer Genome Project is using next-generation whole genome sequencing to determine the complete normal and cancer genomes of children and adolescents with som
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Powerful sequencing technology decodes DNA folding pattern
2. Sequencing works in clinical setting to help -- finally -- get a diagnosis
3. The sequencing of the tomato genome
4. DNA Sequencing: Emerging Technologies and Applications
5. Next-generation sequencing technology opens doors to discoveries
6. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
7. Exome sequencing gives cheaper, faster diagnosis in heterogeneous disease
8. An error-eliminating fix overcomes big problem in 3rd-gen genome sequencing
9. Exome sequencing of health condition extremes can reveal susceptibility genes
10. New genomic sequencing method enables smarter anaysis of individual cells
11. US-Russian collaboration develops new method for sequencing dark matter of life from a single cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 20, 2015 Huntington Memorial Hospital is the ... a new miniaturized, wireless monitoring sensor to manage heart ... and only FDA-approved heart failure monitoring device that has ... by physicians to manage heart failure. The ... in the pulmonary artery (PA) during a non-surgical procedure ...
(Date:4/17/2015)... BURNABY, Canada , April 17, 2015 /PRNewswire/ ... projects, growing security concerns, and technological advancement to ... Arabia until 2020   ... " Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric ... is projected to register growth at CAGR ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... at UT Southwestern Medical Center say there are at ... colon cancer, far more than scientists previously thought. ... 2011 Cancer Research (Priority Reports), researchers are suggesting a ... and pathways simultaneously. Current cancer treatments target just one ...
... research papers that have been recently published in ... Geosystems (G-Cubed). In this release: ... Amazon forest, Episodic tremor triggers small earthquakes, Melting glaciers ... freak waves, Tremor activity changes following two San Andreas ...
... and other "apex consumers" at the top of the food ... is reported by an international team of scientists in a ... . The study looked at research results from a ... "the loss of apex consumers is arguably humankind,s most pervasive ...
Cached Biology News:AGU journal highlights -- July 15, 2011 2AGU journal highlights -- July 15, 2011 3AGU journal highlights -- July 15, 2011 4AGU journal highlights -- July 15, 2011 5AGU journal highlights -- July 15, 2011 6AGU journal highlights -- July 15, 2011 7AGU journal highlights -- July 15, 2011 8AGU journal highlights -- July 15, 2011 9AGU journal highlights -- July 15, 2011 10AGU journal highlights -- July 15, 2011 11AGU journal highlights -- July 15, 2011 12Loss of large predators caused widespread disruption of ecosystems 2Loss of large predators caused widespread disruption of ecosystems 3
(Date:5/27/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/8nqqdw/global_breast ) has announced ... Monoclonal Antibodies Market Outlook 2020" report to ... dominate the breast cancer monoclonal antibody segment because ... has been able to dominate this segment for ... cells become recalcitrant and relapsed condition could not ...
(Date:5/27/2015)... , May 27, 2015 /CNW/ - CQDM, Brain ... close to $8.5M to six (6) multi-disciplinary and multi-provincial ... neuroscience within their Focus on Brain strategic initiative. To ... entities involved as in-kind contributions. This exciting announcement was ... Association for Neuroscience in the presence of Inez Jabalpurwala, ...
(Date:5/27/2015)... May 27, 2015 Empowering biomedical ... combat disease, Cubresa Inc. today announced its MR ... Compatible in-bore PET Scanner uses silicon photomultiplier detector ... preclinical MRI machines from manufacturers like Bruker and ... in Winnipeg, Canada. “This enables simultaneous PET and ...
(Date:5/27/2015)... , May 27, 2015  Two years after ... professionals, hackers and citizen scientists, Oakland ... crowdfunding campaign promoting its mission to democratize science through ... District. ... Based out of the ...
Breaking Biology Technology:Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10Cubresa Launches Simultaneous PET/MRI Technology 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 3
... HAIKOU, China, April 1 /PRNewswire-Asia-FirstCall/ -- Kun Run,Biotechnology, Inc., ... that focuses on manufacture and sales of peptides and,peptide-based ... ended,December 31, 2008. , Revenues ... million, an,increase of $4.1 million, or 56% over revenues ...
... Md., April 1,/PRNewswire-Asia/ -- ACM Global Central Laboratory, ... its inherently flexible,approach, and Chindex International, Inc. (Nasdaq: ... provide central lab services in China at United ... facility owned by Chindex,International, Inc. , ...
... a pathway towards the use of sustainable biofuels on commercial flights ... Environment Summit that begins tomorrow in Geneva, Switzerland. The global Summit ... economic challenges that are part of the international aviation industry,s response ... ...
Cached Biology Technology:Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 2Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 3Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 4Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 5Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 6Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 7Kun Run Biotechnology, Inc. Year-End Revenues Increase 56% to $11.6 million 8ACM Global Central Lab Announces Partnership with Chindex's United Family Hospitals in China 2ACM Global Central Lab Announces Partnership with Chindex's United Family Hospitals in China 3ACM Global Central Lab Announces Partnership with Chindex's United Family Hospitals in China 4Global Aviation Summit Explores Low-Carbon Flight 2
Guanine nucleotide-binding protein G(k), alpha subunit...
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
... P7 D7 F5] to RYK ( ... Antigen: Synthetic ... to amino acids 462 - 475 ... Gene ID: 6259 ...
DAP12 Market Segment: Protein Kinases...
Biology Products: