Navigation Links
Gene regulatory protein is reduced in bipolar disorder
Date:10/25/2011

BOSTON -- Low levels of a brain protein that regulates gene expression may play a role in the origin of bipolar disorder, a complex and sometimes disabling psychiatric disease. As reported in the latest issue of Bipolar Disorders, the journal of The International Society for Bipolar Disorders, levels of SP4 (specificity protein 4) were lower in two specific regions of the brain in postmortem samples from patients with bipolar disorder. The study suggests that normalization of SP4 levels could be a relevant pharmacological strategy for the treatment of mood disorders.

"We found that levels of SP4 protein in the brain's prefrontal cortex and the cerebellum were lower in postmortem samples from patients with bipolar disorder, compared with samples from control subjects who did not have the disease," said co-senior author Grace Gill, PhD, an associate professor in the department of anatomy and cellular biology at Tufts University School of Medicine and a member of the neuroscience; genetics; and cell, molecular and developmental biology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

Gill's laboratory team at Tufts collaborated with researchers from Spain and used postmortem samples from Spain's University of the Basque Country brain collection program to examine SP4 protein levels in samples from 10 bipolar subjects and 10 control subjects matched for gender, age, and time since death.

The team focused on the prefrontal cortex and the cerebellum because brain imaging studies suggest that bipolar disorder is associated with changes in the structure of these brain regions. Little is known about the cellular and molecular changes that occur in bipolar disorder, especially in the cerebellum.

"Our findings suggest that reduced activity of the SP4 protein may be common in bipolar disorder," stated co-senior author Beln Ramos, PhD, a former postdoctoral fellow in Gill's lab and now a researche
'/>"/>

Contact: Siobhan E. Gallagher
617-636-6586
Tufts University, Health Sciences Campus
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New regulatory mechanism discovered for cell identify and behavior in forming organs
2. Caltech researchers help unlock the secrets of gene regulatory networks
3. New data suggest jumping genes play a significant role in gene regulatory networks
4. Food counterfeiting, contamination outpace international regulatory systems
5. Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
6. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
7. Regulatory role of key molecule discovered at Hebrew U.
8. Technique finds gene regulatory sites without knowledge of regulators
9. Novel regulatory process for T cells may help explain immune system diseases
10. Medusa-structure of gene regulatory network: Dominance of transcription factors in cancer subtypes
11. Systech International and Zetes Partner to Meet Europes Emerging Pharmaceutical Regulatory Requirements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... , July 8, 2015 The ... as this summer,s must have products such as wearables, smart ... as popularity for biometrics based devices continues to rapidly grow.  ... Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: GOOG ... FIT ), GoPro, Inc. (NASDAQ: GPRO ) and ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:6/26/2015)... ATL Technology, LLC, a top provider of electromechanical contract manufacturing ... headquartered in Springville, Utah , has announced ... corporation with locations in Santa Clara, CA ... ). This acquisition will incorporate MedConx,s manufacturing facility ... existing facility in Costa Rica , resulting ...
Breaking Biology News(10 mins):Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... TEMPE, Ariz. Seven projects responding to the nation,s ... program launched by Deirdre Meldrum, dean of the Ira ... Meldrum announced Grand Challenges Research Seed Funding grants ... members. They will lead research to answer the call ...
... levels of folate in their red blood cells were more ... a chemical off switch for genes, researchers report in the ... co-author Jean-Pierre Issa, M.D., professor in MD Anderson,s Department of ... of aging, such as heart disease. Methyl groups attach to ...
... Institute announce the release of an online tool that ... strand that tell a cell,s transcription machinery where to ... The Mammalian Promoter Database (MPromDb) integrates the genome ... on human and mouse genomics. MPromDb pinpoints known promoters ...
Cached Biology News:Grants fund projects that will tackle 'Grand Challenges' 2Grants fund projects that will tackle 'Grand Challenges' 3Grants fund projects that will tackle 'Grand Challenges' 4Grants fund projects that will tackle 'Grand Challenges' 5High red blood cell folate levels linked to silenced tumor-suppressors 2High red blood cell folate levels linked to silenced tumor-suppressors 3New annotated database sifts through mountains of sequencing data to find gene promoters 2New annotated database sifts through mountains of sequencing data to find gene promoters 3
(Date:7/27/2015)... , July 27, 2015 Junto Health, a ... share information and develop new technology solutions, today announced ... Group (SPG), a leader in health care policy consulting. ... engage in a collaborative innovation process while, at the ... trends in public policy, health care finance and the ...
(Date:7/26/2015)... ... July 26, 2015 , ... Maine Standards ... verification / linearity test kit. The VALIDATE® ANEMIA kit contains Ferritin, Folate, and ... prepared using the CLSI recommended “equal delta” method for linearity testing and is ...
(Date:7/24/2015)... (PRWEB) , ... July 24, 2015 , ... VetStem Biopharma, ... Center in support of stem cell therapy training and clinical opportunities. , “We are ... opportunity to veterinarians in the San Diego area. Stem cell therapy is an established ...
(Date:7/24/2015)... , July 24, 2015 Orexigen Therapeutics, Inc. ... results for the second quarter 2015 on Thursday, August ... will provide a business update and discuss the financial ... 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... by calling (800) 447-0521 (domestic) or (847) 413-3238 (international), ...
Breaking Biology Technology:Junto Health Announces a Unique Partnership with Sachs Policy Group 2Junto Health Announces a Unique Partnership with Sachs Policy Group 3Junto Health Announces a Unique Partnership with Sachs Policy Group 4Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 2VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 3
... first time, researchers at North Carolina State University ... are physically or chemically different so-called Janus ... an alternating electrical field is applied to liquid ... research, published in the Feb. 8, 2008, edition ...
... Repurchase Program -, LIONVILLE, Pa., Feb. 27 West ... Board of Directors,approved a second quarter 2008 cash dividend of ... 2008 to shareholders of record on April 23,2008., The ... common stock at an average price of $40.23 per share ...
... and CLAREMONT, Calif., Feb. 27 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech ... Kiwa is being considered as a supplier of ... Olympic Village and hotels,during the 2008 Olympics. Kiwa ... and CEO of the Company, would participate in ...
Cached Biology Technology:'2-faced' particles act like tiny submarines 2Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net 2Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net 3
... Steady gravity-fed delivery of buffer and ... perfusion. Rat version. In Vivo Manual ... gravity-fed delivery of buffer and fixative ... to setup, use and clean--Complete system ...
... right in your 35mm dish without ... Perfusion Chamber has separate openings for ... the fluctuations of the liquid level ... bubbles from entering the chamber. An ...
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: