Navigation Links
Gene regulation: Can we stomach it?

About 50 percent of the world's population carry Helicobacter pylori (H. pylori) in their gastrointestinal tract - 30 percent of the German population are infected. Besides cancer, these bacteria are linked to other chronic diseases such as cardiovascular disease. The decoding of the H. pylori genome in 1997 revealed this pathogen to possess surprisingly few genes for transcriptional regulators, sparking a number of crucial questions: Where do the genes of Helicobacter start, and how are these switched on and off? Have all genes been discovered already?

Researchers have been searching for new types of gene regulators in this pathogen, especially for sRNAs. It has recently been realized that these tiny RNA particles are far more abundant in all organisms than previously thought. They can regulate genes by binding to sequences of the genetic information, thereby inhibiting the production of a protein. Yet strangely enough, sRNAs seemed to be lacking in Helicobacter. Jrg Vogel, leader of the RNA Biology Group at the Max Planck Institute for Infection Biology, and his team have finally tracked down a number of sRNAs in the pathogen. To enable their discovery, they modified a technique called "deep sequencing", to decipher millions of RNA-sequences newly produced in a cell. The surprised scientists found 60 sRNAs: "To date, it was believed that this organism completely lacks sRNAs", says Vogel.

A new model for gene regulation?

"We found as many sRNAs in Helicobacter as in widespread intestinal bacteria like Escherichia coli or Salmonella", explains Vogel. But a very important protein required for the regulation of gene expression by sRNAs is missing in Helicobacter pylori. The stomach pathogen possibly uses different signalling pathways, which makes it a possible candidate as a model in RNA-research. "We hope to get completely new insights into gene regulation", says Vogel.

Thanks to the novel technique, the researchers could also define the starting point of every gene in Helicobacter. "It enables us to interpret the genome in a completely new way", explains Vogel. This success, achieved in collaboration with scientists from Leipzig (Germany) and Bordeaux (France), could facilitate the development of a vaccine against the pathogen. Vogel's team will now apply the new sequencing technique to other food-borne pathogens. Interesting candidates are Campylobacter jejuni, which besides Salmonella is the most frequent cause for infectious diarrhoea.


Contact: Jrg Vogel

Related biology news :

1. Team finds link between stomach-cancer bug and cancer-promoting factor
2. Taking sharper aim at stomach ulcer bacteria
3. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
4. Fatty foods -- not empty stomach -- fire up hunger hormone
5. Glutamine supplements show promise in treating stomach ulcers
6. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
7. Stomach ulcer bug causes bad breath
8. New pathogen from pigs stomach ulcers
9. The secret behind silkworms hardy stomachs
10. Early treatment of stomach infection may prevent cancer
11. Cow stomach holds key to turning corn into biofuel
Post Your Comments:
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Disappearing forests and increased emissions are the main causes of ... year. Especially those living in larger cities are affected by air pollution related diseases. ... most pollution-affected countries globally - decided to take action. , “I knew I had ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... ... 10, 2017 , ... Dr. Bob Harman, founder and CEO of VetStem ... The event entitled “Stem Cells and Their Regenerative Powers,” was held ... Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences ... the life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and ... presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach ...
Breaking Biology Technology: