Navigation Links
Gene regulation, not just genes, is what sets humans apart
Date:8/13/2007

DURHAM, N.C. -- The striking differences between humans and chimps arent so much in the genes we have, which are 99 percent the same, but in the way those genes are used, according to new research from a Duke University team.

Its rather like the same set of notes being played in very different ways.

In two major traits that set humans apart from chimps and other primates those involving brains and diet gene regulation, the complex cross-talk that governs when genes are turned on and off, appears to be significantly different.

Positive selection, the process by which genetic changes that aid survival and reproduction spread throughout a species, has targeted the regulation of many genes known to be involved in the brain and nervous system and in nutrition, said Ralph Haygood, a post-doctoral fellow in the laboratory of Duke biology professor Gregory Wray.

Haygood is lead author in a report on the research to be published online on Sunday, Aug. 12, in the research journal Nature Genetics.

His group looked at the regulatory sequences immediately adjacent to 6,280 genes on the DNA of chimps, humans and the rhesus macaque, a more distant primate relative that has 88 percent the same genes as humans. These regulatory stretches of DNA are where proteins bind to the genome to initiate a genes function. And it is here that evolution has apparently fine-tuned the performance of genes, Wray said, resulting in the dramatic differences in the human brain.

Though many studies have looked for significant differences in the coding regions of genes relating to neural system development and failed to find any, the Duke team believes this is the first study to take a genome-wide look at the evolution of regulatory sequences in different organisms.

Other studies have found significant differences between these species in the coding regions that govern the immune system, the sense of smell and the manufacture o
'/>"/>

Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Environment, not genes, key in family relationships
2. Big hips, big belly? Its in your genes, Joslin-led study shows
3. Scientists identify 36 genes, 100 neuropeptides in honey bee brains
4. Yale researchers identify molecule for detecting parasitic infection in humans
5. Friendly bacteria in humans may protect against HIV
6. The lopsided brain: Attention bias is shared by humans and birds
7. Oldest cranial, dental and postcranial fossils of early modern European humans confirmed
8. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
9. UI researcher studies deafness in fruit flies, humans
10. Chickadees can help humans get their bearings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2015)... March 18, 2015 As mobile payments ... revolutionary smart wallets and apps continue to be introduced into ... in the mobile payment industry in focus today are:  NXT-ID, ... (NYSE: BABA ), Apple Inc. (NASDAQ: ... Facebook Inc. (NASDAQ: FB ) NXT-ID, ...
(Date:3/17/2015)... , March 17, 2015  MecklerMedia Corporation (OTCQX: ... exhibition for service robots ever held in ... place on May 11-13, 2015 at the Javits ... for the event include: Acorn Product Development; Axis ... Infranor; Kinova Robotics; Littler; NewBotic Corporation; Neya Systems ...
(Date:3/12/2015)... , March 12, 2015 The mascots ... Brenner Children,s Hospital, part of Wake Forest Baptist Medical ... initiative for the 2015 ACC Men,s Basketball Tournament. Young ... with them and getting their autographs. Brenner ... Baptist. It is the only children,s hospital in northwest ...
Breaking Biology News(10 mins):Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... the parareptiles, a diverse group of bizarre-looking terrestrial vertebrates ... small, slender, agile and lizard-like creatures, while others attained ... and bony spikes on their skulls. The researchers ... by the end-Permian extinction than at any other point ...
... years ago, the understory of late Mesozoic forests was dominated ... Today, only one genus from this group, Equisetum ... a prime candidate for being the oldest extant genus of ... the evolutionary beginnings of the genus Equisetum . Molecular ...
... (SALT LAKE CITY) New findings from University of Utah School of ... in the blood of patients who have chronic fatigue syndrome (CFS). ... study that linked CFS to XMRV. The study, performed by ... Singh, M.D., Ph.D., associate professor of pathology, was published May 4, ...
Cached Biology News:Reptile 'cousins' shed new light on end-Permian extinction 2Newly discovered plant fossil reveals more than age 2Newly discovered plant fossil reveals more than age 3Newly discovered plant fossil reveals more than age 4Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 2Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 3
(Date:3/25/2015)... South San Francisco, CA (PRWEB) March 25, 2015 ... Trial Provide Support for Novel Mechanism of Action ... CA, March 25, 2015 – Cytokinetics, Incorporated (Nasdaq: ... to its fast skeletal muscle troponin activator tirasemtiv ... results from a Phase IIa “Evidence of Effect” ...
(Date:3/25/2015)...  The Technology Association of Georgia ... promotion and economic advancement of Georgia,s ... of its Top 40 Innovative Technology Companies in ... group at the 2015 Georgia Technology Summit (GTS) on ... TAG,S Top 40 Awards recognize Georgia ...
(Date:3/25/2015)... Proove Biosciences , a commercial ... announce the success of their commercially supported symposium, ... Optimize the Management of Pain, at the 31st Annual ... Maryland on Thursday, March 19th, 2015. , ... Lynn Webster , M.D., former Florida Society of ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 ... segmented on the basis of products, technology, ... in this report are radar, laser, infra-red, ... encompassing video guidance systems, terrain mapping systems, ... market data Tables and 60 Figures spread ...
Breaking Biology Technology:Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2Smart Weapons Market is Estimate to reach $6.1 Billion by 2020 Worth $6.1 Billion by 2020 - New Report by MarketsandMarkets 2Smart Weapons Market is Estimate to reach $6.1 Billion by 2020 Worth $6.1 Billion by 2020 - New Report by MarketsandMarkets 3
... May 25 /PRNewswire-Asia-FirstCall/ -- Biostar,Pharmaceuticals, Inc. (Nasdaq: BSPM ... Hepatitis B medicine,Xin Aoxing Oleanolic Acid Capsule ("Xin Aoxing"), and a ... assembly of its production line for its proprietary Zushima product. , ... ...
... NEW YORK , May 25, 2010 ... biosensor and microprocessor technologies for use in,portable monitoring devices, ... the overall daily activity level of an individual and ... overweight or obese. The bracelet,designed both for children and ...
... May 25, 2010 t2cure GmbH, a biopharmaceutical,company developing and marketing ... t2c001 has been,certified by the European Medicines Agency (EMA). , ... t2c001 is the ... Therapy Medicinal Products (ATMPs). It is a somatic,cell therapy product derived from ...
Cached Biology Technology:Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 2Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 3Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 4SPO Medical Announces Innovative Wellness Bracelet 2SPO Medical Announces Innovative Wellness Bracelet 3SPO Medical Announces Innovative Wellness Bracelet 4SPO Medical Announces Innovative Wellness Bracelet 5t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 2t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 3t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 4
... This antibody recognizes murine IRF7 ... with other related IRF proteins. ... murine IRF7 protein was confirmed ... the 293T cells transfected with ...
Sprague-Dawley rats, 7-8 weeks old, mixed gender; tissue is collected fresh, frozen on dry ice within minutes of sacrifice and stored at -20C; individual tissue weight approx. 0.05 gram....
...
Contains L-glutamine...
Biology Products: