Navigation Links
Gene regulation, not just genes, is what sets humans apart
Date:8/13/2007

DURHAM, N.C. -- The striking differences between humans and chimps arent so much in the genes we have, which are 99 percent the same, but in the way those genes are used, according to new research from a Duke University team.

Its rather like the same set of notes being played in very different ways.

In two major traits that set humans apart from chimps and other primates those involving brains and diet gene regulation, the complex cross-talk that governs when genes are turned on and off, appears to be significantly different.

Positive selection, the process by which genetic changes that aid survival and reproduction spread throughout a species, has targeted the regulation of many genes known to be involved in the brain and nervous system and in nutrition, said Ralph Haygood, a post-doctoral fellow in the laboratory of Duke biology professor Gregory Wray.

Haygood is lead author in a report on the research to be published online on Sunday, Aug. 12, in the research journal Nature Genetics.

His group looked at the regulatory sequences immediately adjacent to 6,280 genes on the DNA of chimps, humans and the rhesus macaque, a more distant primate relative that has 88 percent the same genes as humans. These regulatory stretches of DNA are where proteins bind to the genome to initiate a genes function. And it is here that evolution has apparently fine-tuned the performance of genes, Wray said, resulting in the dramatic differences in the human brain.

Though many studies have looked for significant differences in the coding regions of genes relating to neural system development and failed to find any, the Duke team believes this is the first study to take a genome-wide look at the evolution of regulatory sequences in different organisms.

Other studies have found significant differences between these species in the coding regions that govern the immune system, the sense of smell and the manufacture o
'/>"/>

Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Environment, not genes, key in family relationships
2. Big hips, big belly? Its in your genes, Joslin-led study shows
3. Scientists identify 36 genes, 100 neuropeptides in honey bee brains
4. Yale researchers identify molecule for detecting parasitic infection in humans
5. Friendly bacteria in humans may protect against HIV
6. The lopsided brain: Attention bias is shared by humans and birds
7. Oldest cranial, dental and postcranial fossils of early modern European humans confirmed
8. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
9. UI researcher studies deafness in fruit flies, humans
10. Chickadees can help humans get their bearings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
(Date:4/6/2015)... OXFORD, Conn. , Apr. 6, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/143028 for ... CLOSE-PROXIMITY COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces ... wireless payments. This patent surrounds the use of ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... to DNA and then cut these "DNA wires" into ... for future computers. , Findings are detailed in a ... the American Chemical Society. The paper was written by ... an assistant professor of biomedical engineering and chemistry at ...
... Ed : Don't miss out the cool movies, link at ... School of Medicine researchers have found a way to exercise ... jump, beat their wings, and fly on command by triggering ... the insects' central nervous systems, according to a new report ...
... Southampton are continuing their pioneering research into diseases such as ... known as prions, thanks to a £300,000 grant from the ... deaths from confirmed or probable variant CJD (vCJD) in the ... by eating food contaminated with prions that is also responsible ...
Cached Biology News:Purdue researchers use enzyme to clip 'DNA wires' 2Purdue researchers use enzyme to clip 'DNA wires' 3Remote control flies? Fly behavior controlled by laser light 2Remote control flies? Fly behavior controlled by laser light 3
(Date:5/21/2015)... 21, 2015 uBiome, the leading ... partnership with PicnicHealth, a healthcare company that collects ... with Inflammatory Bowel Disease (IBD) will receive a ... uBiome research kit. Both companies were funded by ... , For more information on this partnership and ...
(Date:5/21/2015)... 2015  CytRx Corporation (NASDAQ: CYTR ), ... oncology, today announced positive updated results from its ... the treatment of unresectable glioblastoma multiforme (GBM), a ... trial is designed to investigate the preliminary efficacy ... have progressed following prior treatment with surgery, radiation ...
(Date:5/21/2015)... 2015 Tunnell Consulting, Inc. ... as senior statistician and Principal, a position to which ... the management and analysis of complex and large data ... , “We’re delighted to have Julia join the Tunnell ... said Dr. Philippe Cini, Group Vice President and leader ...
(Date:5/20/2015)... , May 20, 2015  Select Medical ... the Federal Trade Commission granted early termination of ... Improvements Act of 1976, as amended, applicable to ... Acquisition Corporation, a joint venture that Select has ... As previously announced, MJ Acquisition Corporation ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... Fla., Aug. 21 Bioheart, Inc.,(Nasdaq: BHRT ... and,biologics that help monitor, diagnose and treat heart ... $1 million unsecured,loan from Rogers Telecommunications Limited. This ... or Bioheart,s repayment of its loan from BlueCrest,Capital. ...
... to Life Science ... ... the region,s,driving force of innovation and economic development, will soon launch ... provides Michigan,s life science start-ups with valuable,research and technical equipment, donated ...
... GlaxoSmithKline (NYSE:,GSK) today announced that, beginning ... educational and charitable grants provided to US,health-related ... a quarterly,basis and will include grants provided ... care organizations, professional,associations, patient advocacy groups, and ...
Cached Biology Technology:Bioheart, Inc. Announces Additional Funding Support 2Bioheart, Inc. Announces Additional Funding Support 3Bioheart, Inc. Announces Additional Funding Support 4Michigan Innovation Equipment Depot Launches Next Phase of Distribution 2GlaxoSmithKline To Post Quarterly US Grants Report 2
Rabbit polyclonal to VPAC2 ( Abpromise for all tested applications). entrezGeneID: 7434 SwissProtID: P41587...
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
Monoclonal Anti-Cystatin A tissue culture supernatant Solution containing 15 mM sodium azide human cystatin A ...
Biology Products: