Navigation Links
Gene panel predicts lung cancer survival, study finds
Date:7/21/2008

ANN ARBOR, Mich. Researchers from four leading cancer centers have confirmed that an analysis involving a panel of genes can be used to predict which lung cancer patients will have the worst survival. The finding could one day lead to a test that would help determine who needs more aggressive treatment.

The study, the largest of its kind, appears online in Nature Medicine.

The researchers looked at 442 lung cancer tissue samples collected from six cancer hospitals in North America. They tested the cancer samples to look at the expression of hundreds of genes, and factored in clinical predictors such as tumor stage and the patients' gender and age. The results showed that the lung cancers could be divided into groups with better and worse survival rates.

Typically, lung cancer patients receive chemotherapy after surgery to reduce the risk of the cancer coming back. But specialists know that some patients with stage I disease, the earliest stage, have an aggressive disease with poor prognosis while some patients with more advanced stage II disease have a relatively good prognosis. The question is how to identify which patients need the additional therapy and which patients could potentially avoid it.

"We found that looking at clinical data along with gene expression can be a more reliable indicator. Gene expression is not just a black box approach which a lot of researchers think it is. Sometimes knowing the context actually helps you use that information more efficiently," says study author David Beer, Ph.D., professor of surgery and radiation oncology at the University of Michigan Medical School and co-director of the Cancer Genetics Program at the U-M Comprehensive Cancer Center.

Lung cancer is particularly complex, with multiple types and subtypes, most of which are directly related to smoking. There are many genetic alterations induced by tobacco smoke exposure. To be able to offer one simple gene test for the disease, scientists would need to accurately model the known cellular diversity and the potential differences underlying the aggressiveness between lung cancers.

"Our findings suggest that there is a potential for successfully predicting lung cancer prognosis based on gene expression, but it is likely to be more difficult to develop a clinically useful test than has been suggested by previous studies. It's going to require more assay standardization and a large prospective study to identify a signature that is ready for clinical use," says study author Kerby Shedden, Ph.D., associate professor of statistics at U-M.

The researchers will continue to refine this process, identifying the important genes and testing them on tissue samples. They also plan in the future to test their predictors in a prospective trial, enrolling patients as they are diagnosed and following their progress. Enrollment for this trial has not begun.

Four institutions formed a consortium with support from the National Cancer Institute, to develop and validate gene expression signatures of lung cancers. The four institutions are the University of Michigan Comprehensive Cancer Center, H. Lee Moffitt Cancer Center and Research Institute in Tampa, Fla., Memorial Sloan-Kettering Cancer Center in New York, and Dana-Farber Cancer Institute in Boston.

Methodology: The researchers collected lung cancer tissue samples from six centers and grouped them into four sets based on the laboratories where the samples were processed. Two sets served as the "training set," in which researchers looked at several possible gene expression methods to determine whether they could be predictive of patient outcome. They then looked at the other two additional tumor sets for which all outcome data had remained unknown and blinded to the researchers, called "validation sets," to assess whether the outcome of the training set could be duplicated.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related biology news :

1. Nobel Peace Prize 2007 to intergovernmental panel on climate change
2. Neilson member of Nobel Prize-winning panel of scientists
3. IEEE Homeland Security Conference Business Panel to feature experts on technology commercialization
4. Biotechnology key to developing sustainable industries says international panel
5. Cell response to stress signals predicts tumors in women with common pre-breast cancer
6. Built-in exercise monitor predicts fitness
7. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
8. How and where fat is stored predicts disease risk better than weight
9. New study predicts where corals can thrive
10. Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
11. Model successfully predicts large river system fish diversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a range ... place between the two entities said Poloz. Speaking ... Ottawa , he pointed to the country,s inflation ... federal government. "In ... "Both institutions have common economic goals, why not sit down ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
Breaking Biology Technology: