Navigation Links
Gene offers an athlete's heart without the exercise
Date:6/13/2013

Researchers at Case Western Reserve University have found that a single gene poses a double threat to disease: Not only does it inhibit the growth and spread of breast tumors, but it also makes hearts healthier.

In 2012, medical school researchers discovered the suppressive effects of the gene HEXIM1 on breast cancer in mouse models. Now they have demonstrated that it also enhances the number and density of blood vessels in the heart a sure sign of cardiac fitness.

Scientists re-expressed the HEXIM1 gene in the adult mouse heart and found that the hearts grew heavier and larger without exercise. In addition, the animals' resting heart rates decreased. The lowered heart rate indicates improved efficiency, and is supported by their finding that transgenic hearts are pumping more blood per beat. The team also discovered that untrained transgenic mice ran twice as long as those without any genetic modification.

"Our promising discovery reveals the potential for HEXIM1 to kill two birds with one stone potentially circumventing heart disease as well as cancer, the country's leading causes of death," said Monica Montano, PhD, associate professor of pharmacology, member of the Case Comprehensive Cancer Center, who created the mice for the heart and breast cancer research and one of the lead researchers.

Hypertension and subsequent heart failure are characterized by a mismatch between the heart muscles' need for oxygen and nutrients and blood vessels' inability to deliver either at the rate required. This deficit leads to an enlarged heart that, in turn, often ultimately weakens and stops. The researchers showed that increasing blood vessel growth through the artificial enhancement of HEXIM1 levels improved overall function HEXIM1 may be a possible therapeutic target for heart disease.

The study, published online in the peer-reviewed journal Cardiovascular Research, is the sixth from the team of Dr. Montano and Mi
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New report offers science-based strategies for management of western free-ranging horses and burros
2. Philips CX50 xMATRIX now offers world-class interventional and diagnostic features on single portable system
3. AegisCare Offers Specialized Home Health Care for Dementia and Alzheimers Patients
4. Bird flu mutation study offers vaccine clue
5. Researcher offers clues on the origins of life
6. Peach genome offers insights into breeding strategies for biofuels crops
7. Study offers new insights on invasive fly threatening US fruit crops
8. CETS offers new method to help simplify the study of brain pathologies
9. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
10. Study of human specimen collections in the US offers first look at their huge diversity
11. Dartmouth research offers new control strategies for bipolar bark beetles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... their offering. One major trend ... multimodal biometric systems. Multimodal biometric systems utilize more ... and identification purposes. This helps to reduce the ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
(Date:12/5/2014)... 4, 2014  Tute Genomics, a leader in cloud-based ... Series A1 funding led by UK-based Eurovestech. Peak Ventures ... the investment round. "We are at a ... next-generation sequencing and seeks new approaches for the diagnosis, ... , MD MBA, and CEO of Tute Genomics. "One ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... The average American child from age 8 to 18 ... have a TV in the bedroom and about one-third of ... that TV viewing time during childhood and adolescence continues into ... team from the Pennington Biomedical Research Center in Baton Rouge, ...
... on environmental issues such as climate change, deforestation, and ... But new research suggests that environmental messages framed in ... terms of fending off threats to the "purity" and ... to narrow the partisan gap. A study from ...
... deforestation and toxic waste, the assumption has been that conservative ... the University of California, Berkeley, suggests that such viewpoints can ... to be better stewards of the land are couched in ... of Earth and our bodies. A UC Berkeley study ...
Cached Biology News:Bedroom TV viewing increases risk of obesity in children 2Messages that speak to conservatives' morals narrow partisan gap on environment 2Messages that speak to conservatives' morals narrow partisan gap on environment 3Conservatives can be persuaded to care more about the environment 2Conservatives can be persuaded to care more about the environment 3
(Date:12/22/2014)... 2014 ITRA Global, one of the ... commercial real estate, has further expanded its global reach ... and Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman ... ITRA Global / ACORPP (Australian Corporate Property and Projects) ... providing property services to a wide range of clients ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... Dec. 19, 2014  Roche (SIX: RO, ROG; OTCQX: ... Inc. (Bina), a privately held company based in ... Bina provides a big data platform for centralized ... data. Bina,s proprietary on-market Genomic Management Solution, Bina-GMS ... to perform fast and scalable analyses to maximize ...
(Date:12/19/2014)... DUBLIN , Dec. 19, 2014 Research ... announced the addition of the "Technology Innovations ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Innovations in Smart Fabrics" offers a detailed assessment ... Key Findings: 1. ...
Breaking Biology Technology:ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... 40% this morning after it announced that Avastin, which many ... has been found to extend the lives of colon cancer ... and a regulatory decision buttressed the outlook for medicines that ... people ) is developing with smaller biotech partners. But ...
... Alex Bratton is determined to give heavy email users something they ... EmailRx , and a heavy email user, talks about the inspiration ... and the wireless world. , , WTN: How much email do ... receive around 1,000 messages a day from various email accounts with ...
... Valhalla, New York, has selected Verisis developed by Camtronics ... , for its new Cardiology Image and Information Management System. ... George E. Reed Heart Center , one of the most ... coast. The system will also extend into the Children's ...
Cached Biology Technology:Genentech's Winning Streak 2Genentech's Winning Streak 3WTN Interview: Alex Bratton: EmailRX's founder on viruses and spam 2WTN Interview: Alex Bratton: EmailRX's founder on viruses and spam 3NY Medical Center Selects Camtronics for Cardiovascular Image and Information Management 2
Mouse monoclonal antibody to PPP2R2C - protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
... used to quantitate double-stranded DNA (dsDNA) in solution, ... With this kit, DNA is stained with Hoechst ... VersaFluor or other fluorometer. The kit quantitates dsDNA ... to 5 micrograms per ml and contains Hoechst ...
... combines enterprise-scale sequence analysis software with the DeCypher ... With DeCypher, you can perform searches like these ... NCBI NT database in under 6 days ... DNA Use HMM analysis to compare ...
Biology Products: