Navigation Links
Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
Date:5/20/2008

DALLAS May 20, 2008 Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and provide an animal model for developing treatments.

This is one of the most dramatic sleep-disturbance mutations, said Dr. Rolf Joho, associate professor of neuroscience and senior author of the paper, which appears online today and in the May 21 issue of The Journal of Neuroscience. The mice sleep half as much as normal mice.

The mutant mice appeared to have a condition similar to a human disorder called sleep maintenance insomnia, in which sufferers can get to sleep, but dont remain at rest for long.

Were trying to look at where in the brain this originates, Dr. Joho said. The same mechanism could be involved in many neurophysiological disorders.

The researchers focused on two genes that encode molecules known as ion channels. An ion channel is a pore that spans a cells membrane, opening and closing to allow charged atoms, or ions, to cross the membrane. The coordinated opening and closing of various ion channels allows nerve cells to carry electrical signals.

In the current study, the researchers examined two channels that allow potassium ions to cross the cell membrane. The researchers genetically engineered mice to have defects in the ion channels Kv3.1 and Kv3.3, which normally open and close much faster than other potassium channels.

These channels are common in a portion of the brain called the thalamic reticular nucleus, which is thought to act as a pacemaker during sleep, controlling slow-wave sleep the deep, restful sleep that occurs without dreams.

The mutant mice slept only 50 percent to 60 percent as much as normal mice. Measurements of their brain waves showed that they entered slow-wave sleep, but only for short periods before waking again.

The mice did not readily get restful sleep even after sleep deprivation, the researchers found.

In future studies, the researchers hope to focus on the Kv3.1 mutation alone, which they believe, based on previous studies might be the primary factor in the sleep disturbances, while Kv3.3 mutations might affect muscle coordination.

The researchers also plan to investigate ways to restore function of Kv3.1 with potential drugs. So far, there are no medications that affect this ion channel.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related biology news :

1. Rare genetic mutations protect against hypertension
2. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
3. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
4. New study reveals for first time how BRCA1 mutations cause breast cancer
5. Genetic variant mimics effect of heart failure medications
6. Researchers mimic bacteria to produce magnetic nanoparticles
7. Zoologists challenge longstanding theory that eyespots mimic the eyes of predators enemies
8. Team of chemists receives $5 million grant to develop enzyme mimics
9. 4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats
10. Snoozing worms help Penn researchers explain the evolution of sleep
11. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
Breaking Biology Technology: