Navigation Links
Gene mutations caused by a father's lifestyle can be inherited by multiple generations
Date:7/1/2013

Bethesda, MD -- Gene mutations caused by a father's lifestyle can be inherited by his children, even if those mutations occurred before conception. What's more, these findings show that mutations in the germ-line are present in all cells of the children, including their own germ cells. This means that a father's lifestyle has the potential to affect the DNA of multiple generations and not just his immediate offspring. These findings were published in the July 2013 issue of The FASEB Journal.

"Our study should be regarded as a pilot study," said Roger Godschalk, Ph.D., a researcher involved in the work from the Department of Toxicology and the School for Nutrition, Toxicology and Metabolism at Maastricht University in the Netherlands. "We hope that our findings support the initiation of new, more elaborate studies that investigate the role of daily life exposures on germ-line mutations transmitted to offspring."

To make this discovery, Godschalk and colleagues looked at two groups of families (father, mother and child) from the Norwegian Mother and Child Cohort Study. The first group had a low yearly income, whereas the second group had a relatively high yearly income. The investigators chose income as a criterion because it generally correlates to lifestyle choices of the parents. For instance, fathers in the low income group were more often cigarette smokers than fathers in the high income group. Researchers looked for DNA mutations in the children and found that they were more frequent in the group with low income fathers than in the group of high income fathers. These results suggest that the parents living conditions before conception may directly impact the health of their children.

"We've known for a very long time that preventive care among expectant mothers is critical to the health and well-being of their children," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Now, we're learning that fathers don't get a free pass. How they take care of themselveseven before conceptionaffects the genetic makeup of their children, for better or worse."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Gene mutations cause massive brain asymmetry
3. Interacting mutations promote diversity
4. Mutations in autism susceptibility gene increase risk in boys
5. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
6. New gene mutations linked to ALS and nerve cell growth dysfunction
7. Key mutations discovered for most common childhood brain cancer
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
10. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
11. Populations survive despite many deleterious mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... From industry leaders, sports stars, and ... medicine failed. Many of these people had lost all hope. Their stories ... Free Download (pdf) , “Neil takes readers on a riveting journey through ...
(Date:9/19/2017)... PA (PRWEB) , ... September 19, 2017 , ... ... joining Philadelphia’s largest group of funded early-stage tech companies. “Grit” author Angela Duckworth ... tenant. Also joining the ic@3401 community is Cooley, an international law firm with ...
(Date:9/19/2017)... ... 19, 2017 , ... Avomeen Analytical Services, an Ann Arbor ... Science Student Award. The scholarship program is dedicated to helping those who demonstrate ... costs of obtaining their science education. , Avomeen began the annual scholarship program ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... move of the SPIE Digital Library ( http://www.spiedigitallibrary.org ) on 15 August to ... an improved user experience and incorporate a number of enhancements and new features, ...
Breaking Biology Technology: