Navigation Links
Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
Date:2/18/2009

that can put patients at higher risk for infections. In some instances, patients have to be taken off the drug or have their dosage reduced to the point where they risk rejection of the new organ.

The current study analyzed 38 children who had received kidney transplants. Sixteen of the children experienced adverse side effects from MMF therapy. In the adverse reaction group, nine children with the specific UGT point mutation developed leukopenia. The researchers found no strong association between UGT gene variants and diarrhea the most common side effect linked to MMF suggesting gastrointestinal reactions to the drug may be caused by other factors.

Some previous studies have linked UGT gene mutations and MMF-related side effects in kidney transplant recipients, while others have suggested a greater risk for adverse events in children. A review of earlier research combined with their current data led researchers in this study to conclude that pediatric kidney transplant recipients on MMF therapy have a significantly higher likelihood of drug-related complications than adult patients. One previous study compared 22 pediatric and 37 adult transplant recipients, all who started with the standard recommended doses of MMF. Among the children, 54.5 percent experienced adverse side effects compared to 21.6 percent of the adults.

Besides the UGT1A9-331 point mutation, other studies have also linked a second variation, called UGT2B7-900, to possible MMF overexposure and development of leukopenia, said Tsuyoshi Fukuda, Ph.D., co-author on the current study and a colleague in Dr. Vinks' division at Cincinnati Children's. The research team recently completed pharmacokinetic and biomarker studies which analyze how the body metabolizes a drug to solidify the connection between different variants of UGT and MMF overexposure in pediatric kidney transplant patients.

Researchers want to use data from these pharmacokinetic studies as a basis
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Presence of gene mutation helps guide thyroid cancer treatment
2. Mutation of the COX2 gene can double or treble a womans risk of ovarian cancer
3. New study reveals for first time how BRCA1 mutations cause breast cancer
4. Men unaware of their cancer risk when female relatives test positive for BRCA mutation
5. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
6. Mutation may cause inherited neuropathy
7. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
8. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
9. Rare genetic mutations protect against hypertension
10. Inherited cancer mutation is widespread in America
11. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... listen carefully to someone, the first thing we do ... stop moving altogether. This strategy helps us hear better ... , This interplay between movement and hearing also has ... has long suggested that the brain,s motor cortex, which ... rise to our conscious perception of sound. , A ...
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
(Date:8/27/2014)... beasts. But every creature is a baby once. , ... of 24 very young dinosaurs and one older individual ... a caretaker, according to a new study by University ... Peter Dodson led the work, collaborating with researchers from ... is held. Hedrick is a doctoral student in the ...
Breaking Biology News(10 mins):Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3
... the first time, traced the nanoparticles taken up from ... states of their metallic elements. Zinc was shown to ... cerium did not dissolve into plant tissue. The results ... nanoparticles and whether engineered nanoparticles can enter into the ...
... JOLLA, CA----You might think you have nothing in common ... a plant from the mustard family, Salk scientists have ... directly regulate chemical reactions that quickly adjust the growth ... different body parts coordinate their growth, shedding light on ...
... the performance of technologies ranging from medical CT scanners ... extract specific information from huge collections of data and ... new approach is called model-based iterative reconstruction, or MBIR. ... and error, assessing probability and discarding extraneous information," said ...
Cached Biology News:X-rays reveal uptake of nanoparticles by soya bean crops 2X-rays reveal uptake of nanoparticles by soya bean crops 3Plants cut the mustard for basic discoveries in metabolism 2Plants cut the mustard for basic discoveries in metabolism 3New modeling approach transforms imaging technologies 2New modeling approach transforms imaging technologies 3New modeling approach transforms imaging technologies 4
(Date:8/27/2014)... mysteries is how plants survive impact by the ... rays, while using this energy for photosynthesis. The ... plant,s blades quickly dissipate the energy throughout the ... at DTU Physics have now managed to successfully ... bacteria contain light-absorbing proteins which play a role ...
(Date:8/27/2014)...  Lisa Kulik saw fireworks for the first time ... to a groundbreaking retinal implant co-invented by Mark ... the University of Southern California (USC) Eye Institute. ... resident who has retinitis pigmentosa, a degenerative ... June 2, she became the first person west of ...
(Date:8/27/2014)... Reportbuyer.com has added a new market ... A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds graphene, ... to water treatment, but is graphene the only ... Graphene Opportunity Report, authored by Tim Harper ...
(Date:8/27/2014)... -- ARCH Venture Partners, one of the largest U.S. ... seed and early-stage advanced technology companies, today announced ... than $400 million in subscriptions. ARCH Venture Fund ... more than $150 million. "The enthusiasm ... of our approach to finding and funding new ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3
... signal transduction pathway readout , , Lisa ... Buchanan ,John Bauer Chao-Feng Zheng ,Stratagene , Stratagene ... HLR-Elk1, and HLR-cJun, cell lines F ... transcription,factors CREB, Elk1, and c-Jun. These stable HeLa cell ...
... StrataPrep nucleic acid,purification kits , , ... Inc. , , Stratagene announces a new line ... high-purity miniprep plasmid, PCR product and,gel-fractionated DNAs. Purified ... miniprep kit is easily digested with restriction enzymes, ...
... purification from a more versatile vector , ... ,Epitope Tagging in E. coli , Katherine Felts ... ,Stratagene , Stratagene has improved the Affinity ... vector. This new E. coli cloning and expression,vector ...
Cached Biology Technology:Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 2Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 3Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 4Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 5Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 6Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications,and Agarose Gels 2Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications,and Agarose Gels 3Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications,and Agarose Gels 4Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications,and Agarose Gels 5Simple Purification of DNA from Plasmid Minipreps, PCR Amplifications,and Agarose Gels 6High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 2High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 3High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 4High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 5High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 6High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 7High-Level Protein Expression, One-Column Purification, and FLAG,Epitope Tagging in E. coli 8
... used for single-color real-time detection using SYBR ... fluorophores and features a real-time PCR thermal ... 96 wells, a gene expression macro for ... system includes the optical module and optical ...
... Precision-designed for Optimal Microdissection , CapSure HS ... precise and rapid extraction of populations of ... samples with Laser Capture Microdissection., Ensure ... Molecular Analysis , All CapSure LCM Caps ...
... detection system offers an affordable alternative for ... such as FAM and SYBR Green I. ... thermal cycler, offering superior features such as ... MyiQ real-time PCR detection system is a ...
Opticon continuous fluorescence detector; includes optical base, analysis software, computer and monitor (this is an accessory for the DNA Engine thermal cyclers which must be ordered seperately)...
Biology Products: