Navigation Links
Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
Date:2/18/2009

CINCINNATI Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at higher risk for side effects, including compromised white blood cell count or organ rejection, according to new research.

Published online Feb. 18 by the Nature journal Clinical Pharmacology and Therapeutics, the study suggests this genetic approach could also help physicians tailor personalized anti-rejection drug doses to prevent adverse reactions, said senior investigators Alexander A. Vinks, Pharm.D., Ph.D., and Jens Goebel M.D., of Cincinnati Children's Hospital Medical Center.

"There are better ways than just giving standard doses of these drugs, and in due course these types of technologies will be available worldwide to help patients," said Dr. Vinks, director of the Division of Clinical Pharmacology and the Pediatric Pharmacology Research Unit at Cincinnati Children's. "This pilot study shows personalized and prospective MMF dosing and monitoring may be feasible to reduce the high incidence of drug toxicity in children without compromising the drug's protective effects against kidney graft rejection."

MMF, or Mycophenolate Mofetil, is an immunosuppressive agent commonly used to prevent rejection in organ transplants, particularly in kidney transplants. After taken orally, the drug is quickly processed by the body into active form. During this time, patients with a specific point mutation in the gene that helps break down the drug, UGT, metabolize the drug slower. This point mutation, called UGT1A9-331, causes overexposure and adverse side effects in the affected children, the study concluded. UGT encodes the drug's main metabolizing enzyme in the body, uridine diphosphate-glucuronosyl transferase.

Adverse side effects most commonly linked to MMF have included gastrointestinal complications (such as diarrhea) or leukopenia a drop in white blood cell count
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Presence of gene mutation helps guide thyroid cancer treatment
2. Mutation of the COX2 gene can double or treble a womans risk of ovarian cancer
3. New study reveals for first time how BRCA1 mutations cause breast cancer
4. Men unaware of their cancer risk when female relatives test positive for BRCA mutation
5. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
6. Mutation may cause inherited neuropathy
7. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
8. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
9. Rare genetic mutations protect against hypertension
10. Inherited cancer mutation is widespread in America
11. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2009)...using recordings of birdsong to accurately measure...ime sound recordings from a microphone array have ...ecies, populations. Because the new technique, rep... of Applied Ecology , will also work with whale so...y to monitor whale and dolphin numbers. , Develo...
(Date:11/25/2009)... Institute of Technology (Caltech) have uncovered ...he fruit fly, Drosophila melanogaster . , Their...ip between the neurotransmitter dopamine and atten...scribed in the December issue of the journal Neur...t 20,000 neurons and has long been considered a po...
(Date:11/25/2009)...linchpin of the environment, where atmosphere, bio...tudents see soil as "just dirt" a place to grow p...e challenged with the task of helping students and...oil in the environment. , A collaborative proje...niversity of Nebraska-Lincoln, Oregon State Univer...
Breaking Biology News(10 mins):Ecologists sound out new solution for monitoring cryptic species 2Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 2Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 3Caltech scientists find emotion-like behaviors, regulated by dopamine, in fruit flies 4It's not just dirt! 2Abaxis Inc to Present at the CL Kings Seventh Annual Best Ideas Conference 2009 56573 1DJ AM 3A Why He Went Too Far Phoenix House Thought Piece for National Recovery Month by Dr Deni Carise 56569 1DJ AM 3A Why He Went Too Far Phoenix House Thought Piece for National Recovery Month by Dr Deni Carise 56569 2DJ AM 3A Why He Went Too Far Phoenix House Thought Piece for National Recovery Month by Dr Deni Carise 56569 3DJ AM 3A Why He Went Too Far Phoenix House Thought Piece for National Recovery Month by Dr Deni Carise 56569 4Pro Quarterback David Garrard Aims to Score Big For Crohns Disease During the 2009 Football Season 56565 1Pro Quarterback David Garrard Aims to Score Big For Crohns Disease During the 2009 Football Season 56565 2Pro Quarterback David Garrard Aims to Score Big For Crohns Disease During the 2009 Football Season 56565 3Pro Quarterback David Garrard Aims to Score Big For Crohns Disease During the 2009 Football Season 56565 4
...rent condition of the oceans, their significance a...lation, and their impact on the climate will be at...w look on the ocean, at the Euroscience Open Forum...eminar will be on utilisation and monitoring of co...tries and society. Friedhelm Schröder and Wilhelm ...
...th modern genomic tools, it,s a daunting task to f...blem lies in being able to say not just when and h...enetic change translated into real-world dominance... biologists, using an ingenious experiment that fo... for evolutionary dominance, today offer the first...
...sts at St. Jude Children,s Research Hospital have ...s ago against one antigenic variant of the avian i...ure variants of the virus. Vaccines based on this ...for use during a pandemic (worldwide epidemic) unt...gainst the variant causing the outbreak, the resea...
Other Biology News:A new look at the state of the oceans 2A new look at the state of the oceans 3Ready, set, mutate?and may the best microbe win 2Ready, set, mutate?and may the best microbe win 3Scientists to employ Arctic ice and polar bears to protect diversity of world's crops 2
(Date:11/27/2009)... A mechanised blue dye test alte...ackaging quality assurance one step closer for pha...t leak testing machine developed by Sepha for ...talled in several local and global pharma-companie...ss quality assurance and productivity improvements...
(Date:11/25/2009)... , ,, BOCA RATON, Fla., No...s been a painful year. Not so for BodyLogicMD. Th...expert physicians specializing exclusively in medi...n the number of physicians in its network si...d is in progress to add more physician-owned cente...
(Date:11/24/2009)...release is available in German . , Whether ...rds: RFID tags (Radio Frequency Identification) ar...e. They make it possible to label objects or goods...y. The appropriate scanner can read and process th... affixed to goods under production conditions of u...
(Date:11/24/2009)..., CALGARY and BLENHEIM, Ontario, Nov. 24 /PRNews...ed today it is acquiring the assets of Hyland Seed...tario. The addition of Hyland Seeds will further e...the company anticipates the introduction of Smart...de Tolerant Trait Technology in corn in 2012. The ...
Breaking Biology Technology:Sepha's Blue Dye Test Alternative Brings ‘Complete Automation' To Pharma-Packaging Quality Assurance 2Sepha's Blue Dye Test Alternative Brings ‘Complete Automation' To Pharma-Packaging Quality Assurance 3Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 2Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 3Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 4Intelligence inside metal components 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3
...technology associated with his digital product isn...ress its flaws and transform it for the voice-reco...ge Madison business called VoVison , has ambitiou...hnology, which has three differentiating features:...bility to work with multiple voices. , ,The techno...
...series of articles on developing start-up companie...most recent article focused on the tax law implica... this article, the authors address unemployment in...loyment insurance statute has its own test for det...his test is similar in many respects to the common...
...c business sector continued its crash in 2001, the...ting the shutdown of their Wisconsin-based busines...vents of Sept. 11 forced postponement of the board.... , ,When the fateful meeting finally took place a...rs to keep the division going, but lost out. The o...
Other Biology Technology:Tech upstart VoVision could disrupt the voice-recognition market 2Tech upstart VoVision could disrupt the voice-recognition market 3Tech upstart VoVision could disrupt the voice-recognition market 4Early Stage, Step 8: Misclassifying workers brings risk 2Early Stage, Step 8: Misclassifying workers brings risk 3Early Stage, Step 8: Misclassifying workers brings risk 4Early Stage, Step 8: Misclassifying workers brings risk 5Connecture's Maynard finds IT business opportunity in adversity 2Connecture's Maynard finds IT business opportunity in adversity 3Connecture's Maynard finds IT business opportunity in adversity 4Connecture's Maynard finds IT business opportunity in adversity 5Connecture's Maynard finds IT business opportunity in adversity 6
Cynomolgus macaque serum from Alpha Genesis, Inc.
Anti-Foam Reagent from Promega
Rat Tissue Array: Brain, heart, kidney, liver, lung, muscle, spleen and stomach, each tissue from 10 female and 10 male, respectively from BioChain
EPH electrode, anode from GE Healthcare, formerly Amersham Biosciences
Biology Products: