Navigation Links
Gene mutation immortalizes malignant melanoma
Date:1/25/2013

lways seems to have been overlooked," says Kumar.

Rajiv Kumar, Dirk Schadendorf and their teams are hoping that the alterations in the telomerase gene may be a starting point for developing novel treatment methods for malignant melanoma. A very recent development targeting a specific alteration in the B-RAF gene, which characterizes about half of all melanomas, has shown that this is possible. The mutation gave rise to the development of a targeted drug that can arrest cancer growth. "Substances inhibiting telomerase have already been developed and some of them have even been tested in phase III clinical trials," said Rajiv Kumar. Inhibition of the immortality enzyme might also be able to arrest growth in melanoma.


'/>"/>

Contact: Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers attack HIVs final defenses before drug-resistant mutations emerge
2. EGFR mutation not prognostic factor in non-small cell lung cancer
3. Architecture of rod sensory cilium disrupted by mutation
4. Duke Medicine news -- Genome sequencing of Burkitt Lymphoma reveals unique mutation
5. Mutations in genes that modify DNA packaging result in Facioscapulohumeral Muscular Dystrophy
6. USF researchers identify gene mutation linked to old age hearing loss
7. Chinese scientists discover MVK mutations associated with DSAP
8. Study reveals how common gene mutation affects kids with autism spectrum disorders
9. Most mutations come from dad
10. Populations survive despite many deleterious mutations
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... The Marshall Institute for Interdisciplinary Research (MIIR) ... of Medicine today announced they will be partnering ... anti-cancer drugs. , Under the agreement with Shanghai-based ... share the costs and risks of discovery and ... jointly own any intellectual property and commercialization rights ...
(Date:7/10/2014)... controversy centres around a family of enzymes known as ... group in their active site. At the centre of ... becomes oxidised (ferryl) when a reacting heme is in ... has remained unanswered for decades is whether this oxidation ... group (OH). Resolving this fundamental question has implications for ...
(Date:7/10/2014)... GOES-West satellite spotted smoke over the U.S. Mid-West ... Territories. , At 1200 UTC (8 a.m. EDT) ... of the brownish-colored haze created by forest fires ... way into South Dakota. This image was created ... Space Flight Center, Greenbelt, Md. , According ...
Breaking Biology News(10 mins):Marshall University to partner with international company in drug development venture 2Neutron crystallography solves long-standing biological mystery 2Neutron crystallography solves long-standing biological mystery 3
... rivals the honeybees to learn where the best food resources ... London. Writing in the journal PLoS ONE , ... Sciences explain how they trained a colony of bumblebees ( ... species, the honeybee ( Apis mellifera ), as well as ...
... the University of Melbourne shows how the malaria parasite ... before sexual reproduction, a finding that could provide targets ... the parasite evades the human immune system. The ... by Dr Matthew Dixon and PhD student Megan Dearnley ...
... tool has been developed to improve the accuracy and extent ... ,Geo-Wiki, uses Google Earth and information provided by a ... to verify existing land cover information. Developers this week have ... and to encourage community involvement in environmental monitoring. ...
Cached Biology News:Bumblebees get by with a little help from their honeybee rivals 2Malaria parasite goes bananas before sex: New study 2New web tool to improve accuracy of global land cover maps 2New web tool to improve accuracy of global land cover maps 3New web tool to improve accuracy of global land cover maps 4
(Date:7/10/2014)... According to the International Atomic Energy Agency (IAEA) ... terrorists acquiring sufficient quantities of plutonium or highly ... explosive device. The IAEA also notes that most ... quantities, which can be challenging to detect with ... study appearing this week in the Journal ...
(Date:7/10/2014)... D.C., June 17, 2014 Using microscopic polymer ... specific gases, researchers at MIT,s Quantum Photonics Laboratory ... levels in the parts-per-billion range. Optical sensors are ... their high signal-to-noise ratio, compact, lightweight nature, and ... gas sensors had been developed before, the MIT ...
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and ... on a single charge with the help of a ... material to replace the graphite traditionally used in one ... 10 times the energy storage capacity of graphite. A ... electrode was published today in Nature Communications . ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... KONG, Nov. 22, 2011 SuperNova Diagnostics®, Inc., a privately-held ... announced that Neil J. Campbell, President and CEO, will ... Conference on November 30, 2011 at 10:30 a.m. ET ... New York. The presentation will include an ...
... DIEGO, Nov. 22, 2011 Sequenom, Inc. (NASDAQ: ... solutions, today announced the Company,s participation at the 23rd Annual ... York City November 29-30, 2011. Ronald M. ... Paul V. Maier, CFO, will present on Tuesday, November 29, ...
... (Italy), November 21, 2011. CNR Rao, Linus Pauling research ... for Advanced Scientific Research and immediate past president of ... has been named the winner of the 2011 Ernesto ... is designed to give international recognition and visibility to ...
Cached Biology Technology:SuperNova Diagnostics® to Present at the 23rd Annual Piper Jaffray Healthcare Conference in New York City 2Sequenom Announces Participation at the 23rd Annual Piper Jaffray Healthcare Conference 2CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 2CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 3CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 4
Request Info...
Buffer used for mitocapture assays....
... Our entry-level automated perfusion system. For ... perfusion, physiology, biophysics, electrochemistry, or general ... with 10 millisecond accuracy Run ... Microprocessor-based for accuracy and flexibility ...
{3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide}. ,250 ug/ml Propidium Iodide (PI) in PBS....
Biology Products: