Navigation Links
Gene may predict if further cancer treatments are needed
Date:3/28/2014

DALLAS March 28, 2014 UT Southwestern Medical Center researchers are developing a new predictive tool that could help patients with breast cancer and certain lung cancers decide whether follow-up treatments are likely to help.

Dr. Jerry Shay, Vice Chairman and Professor of Cell Biology at UT Southwestern, led a three-year study on the effects of irradiation in a lung cancer-susceptible mouse model. When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

The findings, published online in Clinical Cancer Research, offer insight into helping patients assess treatment risk. Radiation therapy and chemotherapy that can destroy tumors also can damage surrounding healthy tissue. So with an appropriate test, patients could avoid getting additional radiation or chemotherapy treatment they may not need, Dr. Shay said.

"This finding could be relevant to the many thousands of individuals affected by these cancers and could prevent unnecessary therapy," said Dr. Shay, Associate Director for Education and Training for the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. "We're trying to find better prognostic indicators of outcomes so that only patients who will benefit from additional therapy receive it."

Dr. Shay's study closely monitored lung cancer development in mice after irradiation. His group found some types of irradiation resulted in an increase in invasive, more malignant tumors. He examined the gene expression changes in mice well before some of them developed advanced cancers. The genes in the mouse that correlated with poor outcomes were then matched with human genes. When Dr. Shay's team compared the predictive signatures from the mice with more than 700 human cancer patient signatures, the overall survivability of the patients correlated wi
'/>"/>

Contact: Patrick McGee
patrick.mcgee@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
2. Supplement use predicts folate status in Canadian women
3. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
4. University of Toronto biologists predict extinction for organisms with poor quality genes
5. Scientists develop new technique that could improve heart attack prediction
6. Striatal brain volume predicts Huntington disease onset
7. Discovery of mechanisms predicting response to new treatments in colon cancer
8. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
9. Researchers identify genetic markers to predict male fertility
10. Study finds voter genetics may predict election outcomes
11. Math predicts size of clot-forming cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene may predict if further cancer treatments are needed
(Date:8/19/2014)... study that analyzed concentrations of African dust transported ... winter and spring. These research findings offer new ... quality impacts of African dust, including the climate ... occur from increased African dust emissions in the ... (UM) Rosenstiel School of Marine and Atmospheric Science ...
(Date:8/19/2014)... already exist in different forms, they have not been ... production. Now researchers from the University of Surrey and ... common elastic bands with graphene, to create a flexible ... can be made cheaply. , Once treated, the ... with graphene - which imparts an electromechanical response on ...
(Date:8/18/2014)... a person,s gut may protect against or increase susceptibility ... human bacterial intestinal inflammation, according research published this week ... the American Society for Microbiology. The study also found ... to one,s gut bacteria composition. , "It has been ... microorganisms in the gut, can protect a person from ...
Breaking Biology News(10 mins):Study of African dust transport to South America reveals air quality impacts 2What's in your gut? Certain bacteria may influence susceptibility to infection 2
... German . , FRANKFURT. Iron containing short nerve ... a magnetometer to measure the vector of the Earth magnetic ... compass, which shows the direction of the magnetic field lines. ... her husband Prof. Dr. Gnther Fleissner have discovered these structures ...
... sent to evaluate damage from the devastating magnitude-7 earthquake ... evidence of the fault that might have caused the ... help pinpoint the epicenter. , University of Washington civil ... that provided engineering support to the United States Southern ...
... terrain ranging from endless chains of mountains and isolated ... magma and other minerals from below Earth,s surface. This ... and the marine life it supports, is the spotlight ... Oceanography . These massive underwater mountains, or seamounts, ...
Cached Biology News:A magnetometer in the upper beak of birds? 2A magnetometer in the upper beak of birds? 3Earthquake engineers release report on damage in Haiti 2Earthquake engineers release report on damage in Haiti 3Seamounts reach a pinnacle in upcoming issue of Oceanography 2
(Date:8/19/2014)... 19, 2014 CSSi, the leader in patient ... the formation of the company,s Medical and Clinical Advisory ... of Dr. William E. Gannon, Jr. to ... The MCAB, with Dr. Gannon,s leadership, ... areas and set strategic goals for the advancement and ...
(Date:8/19/2014)... 19, 2014   Synthetic Biologics, Inc. ... anti-infective biologic and drug programs targeting specific pathogens ... that its novel C. difficile development ... Interscience Conference on Antimicrobial Agents and Chemotherapy ... Synthetic Biologics, Senior Vice ...
(Date:8/19/2014)... Sales Horizons, a leader in sales training, today ... training course to help companies develop clinical staff ... the majority of their time on client sites – ... practice – providing support and education to both clinical ... believes clinical staff are and should be considered an ...
(Date:8/18/2014)... FL (Aug. 18, 2014) -- A new therapy ... Florida (USF) Morsani College of Medicine and Columbia ... life-threatening complications of interventional cardiovascular disease treatment. ... that the novel molecular therapy could selectively inhibit ... following a medical procedure using a balloon catheter ...
Breaking Biology Technology:CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3
... question asked by state legislators who must pass judgment on ... it?" The second is, "How will it help Wisconsin ... Wisconsin Institute for Discovery is providing some straightforward, and exciting, ... on the UW-Madison campus with half public money and half ...
... in decidedly unromantic spots like little beige offices and ... equity firm Mason Wells , he is the ... its IT venture capital to unknown startups with huge ... events such as the recent Fusion CEO-CIO Symposium ...
... Mozilla Foundation, is offering beleagured e-mail users an alternative, ... of Firefox, the open-source Web browser whose launch included ... the open-source e-mail program Thunderbird reached its 1.0 version ... that makes it easy to focus on mail. ...
Cached Biology Technology:How the Institute for Discovery will help Wisconsin 2How the Institute for Discovery will help Wisconsin 3Successful Wisconsin VC sets sights on data integration and mass storage 2Successful Wisconsin VC sets sights on data integration and mass storage 3Google and Mozilla e-mail apps offer more space, escape from viruses 2Google and Mozilla e-mail apps offer more space, escape from viruses 3
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: