Navigation Links
Gene may hold key to future cancer hope
Date:10/8/2007

Scientists may have discovered a new way of killing tumours in what they hope could one day lead to alternative forms of cancer treatments.

The University of Manchester research has identified a key gene that appears to play a critical role in the normal process of cell division.

Cells divide creating new cells as part of the bodys natural growth, renewal and healing processes but cancer results when cells divide in an uncontrolled way.

What the Manchester team has discovered is that a protein in our cells called Bub 1 is essential for normal cell division to take place; if the gene that generates Bub 1 is switched off then the cells are unable to divide successfully.

Bub 1 is an enzyme that controls several processes required for cell division to occur, said Dr Stephen Taylor, who led the research in the Faculty of Life Sciences.

We have shown that mouse embryos lacking the Bub 1 gene are unable to develop. Older cell types also failed to divide when the gene is switched off, while male mice lacking Bub 1 became infertile as their sperm cells died.

In fact, deactivating Bub 1 had such a profound effect on cell division at all stages of a cells life - known as the cell cycle - that the team is hopeful it will have a similar effect on cancer cells.

Before cells can divide they have to duplicate and then distribute their genetic material so that the two daughter cells receive all the genetic information for further growth and development, said Dr Taylor, whose work is funded by the charity Cancer Research UK.

The distribution phase has to be done with a high degree of accuracy - just one chromosome segregated incorrectly, for instance, leads to Downs syndrome - so the cell has a surveillance mechanism which acts as a brake to delay chromosome segregation until accuracy has been guaranteed.

An important part of this intricate surveillance system is Bub 1. The team found that when the
'/>"/>

Contact: Aeron Haworth
aeron.haworth@hotmail.com
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. HIV vaccine trial breaks ground for future research
2. Future diabetes drugs may target new protein interaction
3. Prozac for future Plants on Mars
4. Purdues gold nanorods brighten future for medical imaging
5. Plants reveal a secret and bring researchers nearer a cleaner future
6. Report focuses on challenges to unlocking future promise of vaccines
7. Researchers make long DNA wires for future medical and electronic devices
8. New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics
9. Understanding the oceans microbes is key to the Earths future
10. Tastier tomatoes in the future?
11. Stable polymer nanotubes may have a biotech future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
(Date:7/7/2015)... VIEW, Calif. , July 7, 2015 /PRNewswire/ ... biometrics market, Frost & Sullivan recognizes Credence ID, ... Sullivan Entrepreneurial Company of the Year Award. ... suite to aid in its mission of offering ... under-recognized populations globally. As Credence ID was formed ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... of eleven organisations, coordinated by the Institute of Environmental ... (ICTA-UAB), will train 18 researchers in Political Ecology over ... European project ENTITLE. The initiative aims to create an ... build a stable collaboration on Doctoral studies that takes ...
... different dosages of vitamin D supplementation in breastfed infants, ... range recommended by some pediatric societies. However, all dosages ... recommended by the Institute of Medicine, according to a ... , a theme issue on child health. Hope ...
... delivering tumor cell-killing enzymes in a way that protects the ... In their study in mBio , the online open-access ... protein packages that can deliver an enzyme called PEIII to ... to the enzyme, they were able to protect it from ...
Cached Biology News:European support for the first network of research and training in political ecology 2European support for the first network of research and training in political ecology 3Optimal vitamin D dosage for infants uncertain 2Optimal vitamin D dosage for infants uncertain 3Protein improves efficacy of tumor-killing enzyme 2
(Date:7/30/2015)... ... July 30, 2015 , ... Tronics, a ... Sales & Marketing Director. , With more than 25 years of experience ... reinforcing Tronics’ business development activities worldwide. He brings to the company his strong ...
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative veterinary medicine ... its canine osteoarthritis stem cell product, currently under development for FDA approval. The ... be marketed in the US by Aratana. This product, termed AT-016, is an ...
(Date:7/30/2015)... , July 30, 2015  With over 60,000 customers across the globe, ISN improves ... 450 hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over ... Headquartered in Dallas, TX ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
Breaking Biology Technology:Tronics appoints Francois Vieillard as Sales and Marketing Director 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... noses modeled after biological olfaction, the challenge has been ... requisite combinatorial complexity to detect odors in the real ... be manufactured with exact chemical precision and reproducibility. , ... open-access journal PLoS Biology, Joel White, Mary AtKisson, John ...
... Fla., Jan. 22 The Delaware Court of,Chancery today ... brought by a,stockholder of Cryo-Cell International Inc. (OTC Bulletin ... of stockholders held,on July 16, 2007. The court ordered ... a special stockholders meeting to be held on March ...
... Hospitals and healthcare,institutions are challenged to devise ... take place while maintaining Environment of Care,(EC) ... these challenges is,available for download at: ... "Infection Control in the Healthcare,Environment During Construction," ...
Cached Biology Technology:Special Stockholders Meeting to Elect Directors Set for March 4, 2008 2White Paper Details Infection Control Challenges Hospitals Must Address During Construction 2
5,6 Carboxyfluorescein is conjugated to BSA (bovine serum albumin) protein through amide bonds....
... Edited by R. Edwards ... on all types of immunoassays, ... surface immunoassays and on the ... immunoassays. Essential information is also ...
... A.P. Johnstone and ... This book describes step-by-step ... of immunologically relevant molecules, ... as highly specific analytical ...
Request Info...
Biology Products: