Navigation Links
Gene linked with death after coronary bypass surgery
Date:9/13/2011

DURHAM, N.C. Duke University Medical Center researchers have found a genetic variant that seems to be associated with lower five-year survival after a coronary artery bypass.

The scientists found the same gene was associated with mortality in two different sets of patients, with about 1,000 patients in each group (1,018 and 930 patients, respectively).

"After the second analysis, we were ecstatic to see this was validated," said senior author Mihai Podgoreanu, assistant professor of anesthesiology at Duke. "This is the first study I know about in the field of perioperative medicine to show increased genetic susceptibility for long-term mortality while replicating the genetic association in an independent cohort."

The study was published in the Sept. 12 issue of Circulation.

The team found common variants in the thrombomodulin (THBD) gene, involved in regulation of blood coagulation and inflammation, to be independently associated with increased long-term mortality risk following a coronary artery bypass graft (CABG) procedure, after accounting for currently known risk factors.

"In any biomarker association study, current wisdom is that there are a lot of false positive findings, so we used specimens from a different, independent cohort of patients to increase our confidence that the initial results were not spurious," Podgoreanu said.

"This finding has the potential to significantly improve the classification ability of traditional mortality-prediction models after a patient's open heart surgery," Podgoreanu said.

He said the findings open up the field for more work, but it is too soon to say how this genetic finding should be used to benefit individual cardiac surgical patients and extend their survival. It's also too soon for great numbers of people to have their genomes sequenced and learn whether they carry this particular gene variant.

That said, Podgoreanu does see ways in which the finding might help patients.

"We need to work to find uses for any sort of biomarker," he explained. "There are possibilities that we could apply this information someday to a patient's prognosis, and for careful monitoring or increased surveillance if a person has a 2.5 times higher risk of dying, instead of letting them go their way after a CABG surgery."

Treatment outcomes also need to be tested according to a "personalized" susceptibility profile. The Duke Clinical Research Institute is known for its work with patients who have cardiac/coronary disease and testing when it is best to employ one of three therapeutic options: 1) medication only, 2) opening a clotted vessel with angioplasty and a stent, or 3) bypassing the clotted vessel with a graft from another vessel, as in CABG procedures, Podgoreanu said. "But at no point has genetic or biomarker information been superimposed on this care-improvement testing process, so the results of this preliminary study will provide ammo for more studies with a genetically stratified trial," he said.

The findings also may benefit patients someday, because genetic results are unchanging. "If we take saliva or blood from patients before surgery and find they carry this gene variant, we can be more sure about their risk profile, as opposed to simply measuring values of the protein product of that gene in their blood profiles that are subject to change, for example, in response to the stress of surgery or medications," Podgoreanu said.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. USC scientists identify key protein linked to acute liver failure
2. Medical homes linked to better health, school performance
3. Bilingual babies vocabulary linked to early brain differentiation
4. Newfound hijacked proteins linked to salmonella virulence
5. Mothers BMI linked to fatter babies
6. Parasite loads an underlying cause of salmon mortality, linked to land use changes
7. Maternal IV fluids linked to newborns weight loss
8. Scientists identify mutation in SIGMAR1 gene linked to juvenile ALS
9. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
10. Atlantic herring population trends linked to egg predation by haddock
11. Indoor air pollution linked to cardiovascular risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 22, 2017 , ... NetDimensions ... in the Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research defines ... market demand, and effectively perform against those strategies. NetDimensions’ ranking as a Leader ...
(Date:5/23/2017)... ... May 23, 2017 , ... Vortex Biosciences , provider ... isolation of prostate circulating tumor cells using Vortex microfluidic technology ” in Nature Precision ... collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig at the University of ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... as Vice President of Clinical Operations. She brings years of expertise in establishing ... From her professional foundation as a licensed occupational therapist, through a variety of ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Cambridge Semantics ... splash at this year’s Bio-IT World Conference and Expo in Boston May ... Lake® 4.0 solution. The Anzo Smart Data Lake is also a finalist for ...
Breaking Biology Technology: