Navigation Links
Gene linked to schizophrenia may reduce cancer risk

People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

The MET proto-oncogene is activated in a variety of tumor malignancies. The gene has recently also been linked to autism and has a role in neurodevelopment, which is why Katherine E. Burdick, PhD and her colleagues decided to look for a relationship between MET and schizophrenia in their large sample of patients. Such an association may help explain the family-based data that suggest that inheriting an enhanced risk for schizophrenia reduces one's chances of developing cancer.

In a study published in the American Journal of Psychiatry, Dr. Burdick and colleagues examined the relationship between 21 single-nucleotide polymorphisms (SNPs) in MET and schizophrenia in 173 patients and 137 normal volunteers. They found that several varieties of MET influenced the risk for schizophrenia, as well as general cognitive ability. The authors were able to replicate their findings in a second sample of 107 patients and 112 healthy volunteers. "The results add to the growing evidence suggesting an intriguing relationship between cancer-related genes and schizophrenia susceptibility," the scientists wrote.

It remains unclear exactly how the gene actually may increase the risk for schizophrenia while protecting against some forms of cancer. However, evidence from research on MET in autism provides some insight. Specifically, it is known that MET is activated (increased activity) when tumors develop and can increase the chance that cancer cells multiply and infiltrate other tissue.

The activation of MET during normal neurodevelopment is critical to ensure that neurons grow and migrate to position themselves correctly in the human cortex. In autism, it appears that while the brain is developing, reduced MET activity results in structural and functional changes in the brain that may increase a person's risk for developing the disorder. The Feinstein investigators speculate that the same risk-inducing mechanism may be at play in its link to schizophrenia.


Contact: Jamie Talan
North Shore-Long Island Jewish (LIJ) Health System

Related biology news :

1. Higher opioid dose linked to overdose risk in chronic pain patients
2. Stable climate and plant domestication linked
3. Coal from mass extinction era linked to lung cancer mystery
4. Study provides insight into pathway linked to obesity
5. A global breakthrough in the study of a protein linked to the spread of viruses
6. Pollution linked to hospitalizations for pneumonia in older adults
7. Gene linked to a rare form of progressive hearing loss in males is identified
8. Prussian blue linked to the origin of life
9. Lifelong memories linked to stable nerve connections
10. Bacterial gut symbionts are tightly linked with the evolution of herbivory in ants
11. Sugary cola drinks linked for first time to higher risk of gestational diabetes
Post Your Comments:
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... will be hosting a Webinar titled, “Pathology is going digital. Is your lab ... digital pathology adoption best practices and how Proscia improves lab economics and realizes ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. 11, ... Research, London (ICR) and University of ... SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma (MM), ... nine . The University of Leeds ... funded by Myeloma UK, and ICR will perform the testing ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
Breaking Biology Technology: