Navigation Links
Gene linked to lupus might explain gender difference in disease risk
Date:3/29/2009

five variants were common in people with either childhood-onset or adult-onset lupus.

To further test the link, the researchers then took mice of a strain that normally is prone to developing lupus and engineered them to lack the IRAK1 gene. In the absence of IRAK1, the animals lacked symptoms associated with lupus, including kidney malfunction, production of autoimmune antibodies and activation of white blood cells.

"The extensive involvement of IRAK1 in the regulation of the immune response renders its association with lupus a prime candidate for careful genetic and functional analysis," Dr. Mohan said.

Future research will investigate the role that X-linked genes, versus hormonal differences, play in the gender susceptibility rates of lupus.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Genetic irregularities linked to higher risk of COPD among smokers
2. Genes identified that are linked to spinal disc degeneration
3. Cats eye diseases genetically linked to diseases in humans
4. Researchers capture wave of brain activity linked to anticipation
5. Decline of shorebird linked to bait use of horseshoe crabs
6. Researchers isolate protein domain linked to tumor progression
7. Researchers identify gene linked to aggressive progression of liver cancer
8. Scientists uncover new genetic variations linked to psoriasis
9. Global warming linked to European viral epidemic
10. Team finds breast cancer gene linked to disease spread
11. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene linked to lupus might explain gender difference in disease risk
(Date:8/27/2014)... Outstanding basic research, a growing focus on ... patient care have earned the Herbert Irving Comprehensive ... (CUMC) and NewYork-Presbyterian Hospital an $18 million, five-year ... Institute (NCI). The grant renews the center,s status ... Centers in New York City and one of ...
(Date:8/27/2014)... has shown that piglets can be weaned later with ... outcome of the study at the University,s Roseworthy campus, ... is an important finding for pig producers. It allows ... production. , "Sows don,t usually start their oestrous cycles ... piglets have been weaned," says Ms Alice Weaver, PhD ...
(Date:8/26/2014)... in St. Louis have developed algorithms to identify weak ... or breaking. The technology, which needs to be refined ... help pinpoint minor strains and tiny injuries in the ... research is available online Aug. 27 in the ... research at the nexus of the physical and life ...
Breaking Biology News(10 mins):Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4Piglet weaning age no bar to litter frequency 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3
... at The Scripps Research Institute and collaborating institutions has identified ... a target for obesity and diabetes drugs. In a ... , the scientists describe a protein called TLE3 that acts ... fat cell formation and turn off those that keep fat ...
... With the Easter holiday season coming up soon, egg consumption ... farms producing the maximum number of eggs they can? "Parasites ... production by five percent or more," says Bradley A. Mullens ... California, Riverside. "One way to boost egg production is to ...
... among a group of researchers investigating how genetic differences ... interact and change over time. They say ... can help society to address issues including food security, ... nature in a crowded world. Biologists from the ...
Cached Biology News:Scripps Research scientists find 'dual switch' regulates fat formation 2Scripps Research scientists find 'dual switch' regulates fat formation 3UC Riverside entomologists propose pesticide-free method to increase egg production 2Genetic differences influence the structure of communities 2
(Date:8/27/2014)... Remcom announces an update to XFdtd® ... the biomedical industry. The central biomedical addition in ... to the Bio-Pro version of the software. XFdtd ... calculate the biological effects of electromagnetic fields. In ... versions to expand engineers’ post-processing options. , The Biological ...
(Date:8/26/2014)... August 26, 2014 New research ... wearable technology, and inspiration for the International Year ... year’s brighter, busier SPIE Optics + Photonics ... More than 4,400 international scientists, engineers, researchers, developers, ... exhibition, and industry sessions sponsored by SPIE, ...
(Date:8/26/2014)... Israel , August 26, 2014 ... supports NHS hospitals with surgery validation using its Stratasys Objet24 ... - Performing surgery on 3D printed models prior to operations ... provides an effective aid for both patient and surgeon ... SSYS ), a global leader of 3D printing and additive ...
(Date:8/26/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
Breaking Biology Technology:Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 2Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 3Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 4Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 5World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 3World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 4World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 5World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 6
... , April 22 As evidence of ... lifetime of physical activity, Smith & Nephew ( SNN, ... unprecedented testing on its VERILAST technology for knee replacement ... the company,s LEGION™ knee replacement, VERILAST technology produced an ...
... YORK and SCOTTSDALE, Ariz. , April ... NBS ), an international biopharmaceutical,company with operations in the ... wholly owned subsidiary of IR BioSciences Holdings, Inc.,(OTC Bulletin ... a,Collaborative Research Agreement, focused on the development of an ...
... ... Follow-on Biologics in Chicago. , ... Chicago (Vocus) April 22, 2010 -- Therapeutic Proteins Inc. (TPI) ... manufacturing facility constructed to meet U.S. Food and Drug Administration (FDA) requirements. The Chicago ...
Cached Biology Technology:Smith & Nephew Receives FDA 510k Clearance for a 30-year Knee 2Smith & Nephew Receives FDA 510k Clearance for a 30-year Knee 3Smith & Nephew Receives FDA 510k Clearance for a 30-year Knee 4Smith & Nephew Receives FDA 510k Clearance for a 30-year Knee 5NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 2NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 3NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 4NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 5NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 6NeoStem, Inc. and ImmuneRegen BioSciences(R) Announce a Collaborative Agreement to Advance Stem Cell Technology 7Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 2Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 3Therapeutic Proteins Inc. Completes First Independent, Dedicated Biosimilars Manufacturing Facility in U.S. 4
Request Info...
... Nuclease catalyzes the degradation of single-stranded DNA ... products. While the nuclease prefers ssDNA over ... the enzyme degrades double-stranded DNA from both ... used for transcript mapping studies (3,4), for ...
... fosmid (40kb), and large plasmid insert (10-20kb) ... BAC vector. On command 20-50 fold copy ... DNA purification. Available with blue-white screening (pEZ ... the highest insert stability. Kits include electrocompetent ...
...
Biology Products: