Navigation Links
Gene linked to lupus might explain gender difference in disease risk
Date:3/29/2009

DALLAS March 30, 2009 In an international human genetic study, researchers at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why females are 10 times more susceptible to the disease than males.

Identifying this gene, IRAK1, as a disease gene may also have therapeutic implications, said Dr. Chandra Mohan, professor of internal medicine and senior author of the study. "Our work also shows that blocking IRAK1 action shuts down lupus in an animal model. Though many genes may be involved in lupus, we only have very limited information on them," he said.

The study appears online this week in the Proceedings of the National Academy of Sciences.

Locating IRAK1 on the X chromosome also represents a breakthrough in explaining why lupus seems to be sex-linked, Dr. Mohan said. For decades, researchers have focused on hormonal differences between males and females as a cause of the gender difference, he pointed out.

"This first demonstration of an X chromosome gene as a disease susceptibility factor in human lupus raises the possibility that the gender difference in rates may in part be attributed to sex chromosome genes," Dr. Mohan said.

Systemic lupus erythematosus, or lupus for short, causes a wide range of symptoms such as rashes, fever or fatigue that make it difficult to diagnose.

The multicenter study involved 759 people who developed lupus as children, 5,337 patients who developed it as adults, and 5,317 healthy controls. Each group comprised four ethnicities: European-Americans, African-Americans, Asian-Americans and Hispanic-Americans.

In previous genetic studies, the researchers had found an association but not a definite link between lupus and IRAK1.

For the current study, the researchers studied five variations of the IRAK1 gene in the subjects, and found that three of the
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Genetic irregularities linked to higher risk of COPD among smokers
2. Genes identified that are linked to spinal disc degeneration
3. Cats eye diseases genetically linked to diseases in humans
4. Researchers capture wave of brain activity linked to anticipation
5. Decline of shorebird linked to bait use of horseshoe crabs
6. Researchers isolate protein domain linked to tumor progression
7. Researchers identify gene linked to aggressive progression of liver cancer
8. Scientists uncover new genetic variations linked to psoriasis
9. Global warming linked to European viral epidemic
10. Team finds breast cancer gene linked to disease spread
11. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene linked to lupus might explain gender difference in disease risk
(Date:7/25/2014)... the first broad-scale estimate of air pollution removal by ... that trees are saving more than 850 human lives ... symptoms. , While trees, pollution removal equated to an ... the impacts of that improvement are substantial. Researchers valued ... at nearly $7 billion every year in a study ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... false-color image from the Terra satellite show the different areas ... in Eastern Russia. The burn scars show up as ... wildfires have broken across the remote parts of Eastern Russia ... from the MODIS instrument, it is still possible to ... recent image features noted below show the devastating number of ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... on the tap to get a glass of water, we just ... really safe? And, what exactly is "safe"? The public ... Marylynn Yates , a professor of environmental microbiology at the University ... will help the audience become familiar with the most common causes ...
... and clean people,s water supplies while serving as important ... cranes and alligators. Conventional ecosystem health assessments have focused ... unseen creatures in the wetlands provided crucial indicators of ... Missouri Associate Professor of Engineering Zhiqiang Hu and his ...
... GSA Bulletin articles posted online ahead of ... in central Asia; (2) crystal xenoliths in the Bolivian Altiplano; ... Group contact, Barberton greenstone belt, South Africa; (5) iron oxide ... Alaska syntaxis; (7) paleotopography of the South Norwegian margin; and ...
Cached Biology News:How safe is our drinking water? 2Measuring microbes makes wetland health monitoring more affordable, says MU researcher 2Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 2Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 3Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 4Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 5Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 6Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 7Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 8Contacts, collisions, sutures, belts, and margins -- new GSA Bulletin content 9
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 /PRNewswire/ ... company in the emerging field of regenerative medicine, ... webcast of a presentation to investors on Tuesday, ... p.m. PDT.  The presentation will include an overview ... To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... Distinguished Professor of Engineering at the University of ... solve problems in energy engineering, environmental sustainability and ... zeolites, porous rock with a well-defined, crystalline structure. ... so precisely decided that zeolites can separate molecules ... an angstrom (one-tenth of a nanometer), making them ...
(Date:7/24/2014)... July 24, 2014 SRI International has been ... National Institute of Allergy and Infectious Diseases (NIAID), part ... development of potential therapies for HIV infection and AIDS. ... HIV and AIDS and the complications and opportunistic infections ... preventing sexual transmission of HIV. According ...
(Date:7/24/2014)... 2014 WIRB-Copernicus Group ® ("WCG")™, ... review services for clinical research, announced today that ... of Richmond, VA -based Alliance ... biosecurity consulting firm in the United ... division – WCG Biosafety™ – will be able ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4University of Delaware researcher describes new approach for creating organic zeolites 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
... , SAN MATEO, Calif., Nov. 6 , ... of Qutenza(TM) E.U. Marketing Authorization to Astellas Pharma Europe Ltd. ... Expanded management team to include VP Sales; Senior Director, Marketing; ... board as director and Audit Committee chairman , ...
... Therapeutics, Inc. delivered two presentations today on its ITCA ... treatment of type 2 diabetes at the Ninth Annual ... http://www.newscom.com/cgi-bin/prnh/20050301/SFTU126LOGO ) , Continuous Subcutaneous Delivery ... and Reduces Weight in a 28-day Phase 1b Study ...
... Md., Nov. 5 GenVec, Inc. (Nasdaq: GNVC ) today ... 2009. GenVec reported a net loss of $3.6 million ($0.04 per ... a net loss of $6.8 million ($0.08 per share) in the ... 2009, GenVec,s net loss was $14.1 million ($0.15 per share), compared ...
Cached Biology Technology:NeurogesX Reports Third Quarter 2009 Results 2NeurogesX Reports Third Quarter 2009 Results 3NeurogesX Reports Third Quarter 2009 Results 4NeurogesX Reports Third Quarter 2009 Results 5NeurogesX Reports Third Quarter 2009 Results 6NeurogesX Reports Third Quarter 2009 Results 7NeurogesX Reports Third Quarter 2009 Results 8NeurogesX Reports Third Quarter 2009 Results 9NeurogesX Reports Third Quarter 2009 Results 10Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 2Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 3Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 4Intarcia Therapeutics, Inc. Presents Positive Results from Two Studies of ITCA 650 for the Treatment of Type 2 Diabetes at the Ninth Annual Diabetes Technology Meeting 5GenVec Reports Third Quarter 2009 Financial Results 2GenVec Reports Third Quarter 2009 Financial Results 3GenVec Reports Third Quarter 2009 Financial Results 4GenVec Reports Third Quarter 2009 Financial Results 5GenVec Reports Third Quarter 2009 Financial Results 6
...
... Vacuum pumps deliver critical performance for all ... control optimizes pump performance to suit all ... for convenient checking of proper oil levels ... pumps is designed to work with all ...
... The IITC Life Science Rotarods are used ... motor coordination or fatigue resistance on mice and ... humane way. Extremely user friendly; the animals are ... an animal drops onto the individual sensing platforms ...
... Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a ... PGF2α), in rabbits, monkeys and humans. ... of non-specific lipid peroxidation. In both ... is converted primarily to metabolites having ...
Biology Products: