Navigation Links
Gene linked to lupus might explain gender difference in disease risk
Date:3/29/2009

DALLAS March 30, 2009 In an international human genetic study, researchers at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why females are 10 times more susceptible to the disease than males.

Identifying this gene, IRAK1, as a disease gene may also have therapeutic implications, said Dr. Chandra Mohan, professor of internal medicine and senior author of the study. "Our work also shows that blocking IRAK1 action shuts down lupus in an animal model. Though many genes may be involved in lupus, we only have very limited information on them," he said.

The study appears online this week in the Proceedings of the National Academy of Sciences.

Locating IRAK1 on the X chromosome also represents a breakthrough in explaining why lupus seems to be sex-linked, Dr. Mohan said. For decades, researchers have focused on hormonal differences between males and females as a cause of the gender difference, he pointed out.

"This first demonstration of an X chromosome gene as a disease susceptibility factor in human lupus raises the possibility that the gender difference in rates may in part be attributed to sex chromosome genes," Dr. Mohan said.

Systemic lupus erythematosus, or lupus for short, causes a wide range of symptoms such as rashes, fever or fatigue that make it difficult to diagnose.

The multicenter study involved 759 people who developed lupus as children, 5,337 patients who developed it as adults, and 5,317 healthy controls. Each group comprised four ethnicities: European-Americans, African-Americans, Asian-Americans and Hispanic-Americans.

In previous genetic studies, the researchers had found an association but not a definite link between lupus and IRAK1.

For the current study, the researchers studied five variations of the IRAK1 gene in the subjects, and found that three of the
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Genetic irregularities linked to higher risk of COPD among smokers
2. Genes identified that are linked to spinal disc degeneration
3. Cats eye diseases genetically linked to diseases in humans
4. Researchers capture wave of brain activity linked to anticipation
5. Decline of shorebird linked to bait use of horseshoe crabs
6. Researchers isolate protein domain linked to tumor progression
7. Researchers identify gene linked to aggressive progression of liver cancer
8. Scientists uncover new genetic variations linked to psoriasis
9. Global warming linked to European viral epidemic
10. Team finds breast cancer gene linked to disease spread
11. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene linked to lupus might explain gender difference in disease risk
(Date:1/22/2015)... CHARLOTTE, N.C. , Jan. 22, 2015 Infinisource has ... introduction of the G2 model. The G2 sets a higher ... company,s iSolved human capital management solution. With plug-and-play installation, touch ... G2 time clock provides a robust time collection solution for ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the brightest ever ... that the long anticipated floodgates for consumer biometrics may ... smart phones, tablets, and wearable mobile devices that incorporate ... users with nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... , Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... Power ... Consumption, TUSTIN, ... high-performance module designed for connecting,devices that require low power consumption to ... applications that need,WLAN connectivity with minimal power usage, such as battery-operated,portable ...
... WASHINGTON -- A new NASA-led study shows human-caused climate ... of Earth,s natural systems, including permafrost thawing, plants blooming ... Africa. Cynthia Rosenzweig of NASA,s Goddard Institute ... 10 other institutions have linked physical and biological impacts ...
... May 13, 2008.-Unlike most scientific and technological advances, which ... often finds itself the center of public debate and ... by many of its applications. , In this ... (the first was in 2003), the sample has been ...
Cached Biology News:New Silex SX-560 Enables Enterprise 802.11 Wireless Connectivity for Battery Operated Devices 2NASA study links Earth impacts to human-caused climate change 2BBVA Foundation international study on attitudes to stem cell research 2BBVA Foundation international study on attitudes to stem cell research 3BBVA Foundation international study on attitudes to stem cell research 4BBVA Foundation international study on attitudes to stem cell research 5BBVA Foundation international study on attitudes to stem cell research 6
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... Johnston, RI (PRWEB) January 22, 2015 ... State , The growing team of brand-neutral, independent consultants, ... CIO Philip Rogers explained that over the years, his ... including , Moroso, Town of Plainfield, as well as ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... Medical Systems (NYSE: VAR ), world leader in ... to sustainability with inclusion on a prestigious list of the ... equipment company among the Corporate Knights Global 100 Most Sustainable ... Davos, Switzerland . "We ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... CHAPEL, Florida, March 20 NexGen,Biofuels Ltd. (OTC:NXGNF) ... its ordinary shares have been approved for quotation ... NexGen is a development stage company that is ... plants and blending assets in,the United States., ...
... increasing physician acceptance of electrophysiology ablation ... fibrillation, according to ... According to Millennium,Research Group,s Global Markets for Atrial Fibrillation ... were,performed for the treatment of AF in the US ...
... LUMEDX Corporation, a leading,provider of fully integrated ... version of its real-time patient and resource,scheduler ... physicians, staff, rooms with drag and drop ... and,substantial ROI., A free CardioSchedule Information ...
Cached Biology Technology:Electrophysiology Procedures for Atrial Fibrillation Treatment to Grow Over 25% Annually Over the Next Five Years 2LUMEDX Updates Real-Time Patient and Resource Scheduler for Healthcare Systems 2
... the world of discovery races ever faster, you ... the fast track. So our constant focus is ... your research. Thats why our Biomek 3000 Laboratory ... as advanced as it is flexible. By integrating ...
... Zymeds MaxArray Rabbit Tissue Arrays contain 60 rabbit ... Each package contains 4 unstained slides and 1 ... reference. Each slide contains 15 different tissues from ... tissue samples per slide. Each tissue sample (or ...
... offers custom peptide synthesis with a wide variety ... fit your research needs. Purity: ... 2mg-1g Sequence Length: Up ... Fluorescein, N-acetylation, C-amidation, phosphorylation, D-amino acids, MAPs, KLH/BSA ...
... sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 ... corresponding peptide and ... 5 I-labelled peptide, please ... and ([ 1 ...
Biology Products: