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Gene limits learning and memory in mice
Date:9/17/2010

Deleting a certain gene in mice can make them smarter by unlocking a mysterious region of the brain considered to be relatively inflexible, scientists at Emory University School of Medicine have found.

Mice with a disabled RGS14 gene are able to remember objects they'd explored and learn to navigate mazes better than regular mice, suggesting that RGS14's presence limits some forms of learning and memory.

The results were published online this week in the Early Edition of the Proceedings of the National Academy of Sciences.

Since RGS14 appears to hold mice back mentally, John Hepler, PhD, professor of pharmacology at Emory University School of Medicine, says he and his colleagues have been jokingly calling it the "Homer Simpson gene."

RGS14 is primarily turned on in one particular part -- called CA2 -- of the hippocampus, a region of the brain known for decades to be involved in consolidating new learning and forming new memories. However, the CA2 region lies off the beaten path scientifically and it's not clear what its functions are, Hepler says.

RGS14, which is also found in humans, was identified more than a decade ago. Hepler and his colleagues have previously shown that the RGS14 protein can regulate several molecules involved in processing different types of signals in the brain that are known to be important for learning and memory. They believe RGS14 is a key control protein for these signals.

To probe RGS14's functions, Sarah Emerson Lee, a graduate student working with Hepler, characterized mice whose RGS14 genes were disabled using gene-targeting technology. In collaboration with Serena Dudek, PhD, at the National Institute of Environmental Health Sciences, they examined how the CA2 region responded to electrical stimulation in the gene-altered mice.

Many researchers have examined how other parts of the hippocampus are involved in long-term potentiation, a strengthening of conne
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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

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