Navigation Links
Gene is likely cause of stroke-inducing vascular malformations
Date:9/2/2008

UCSF scientists have discovered that a gene controlling whether blood vessels differentiate into arteries or veins during embryonic development is linked to a vascular disorder in the brain that causes stroke.

The UCSF studies were done in mice, and the new findings are the first to provide information on both the progression and regression of this particular brain disorder, known as BAVM, and to provide molecular clues into the disease, which is not well-understood and chiefly affects young people.

BAVM, for brain arteriovenous malformation, is a vascular disorder causing arteries and veins to be directly connected, rather than through capillaries. This direct connection produces enlarged, tangled masses of vessels that are prone to hemorrhagic rupture, bleeding and stroke. Because they develop most often in growing tissues, BAVMs are responsible for half of the hemorrhagic strokes in children.

Study findings were published in a recent issue (Aug. 5, 2008) of the Proceedings of the National Academy of Sciences.

The UCSF team identified the gene, known as Notch, as a potential cause of BAVMs because of its role in directing embryonic blood vessel formation. Using genetic tools, the team "turned on" a constantly active Notch gene in endothelial brain cells, which are the cells lining blood vessels in the brain, and found that BAVMs were induced. When researchers turned the gene off, the mice exhibited full recovery from the disease's progression.

"This was exciting. The activated Notch gene caused BAVM in all of the mice, making it an unprecedented, potent molecular lesion in the induction of the pathology," said Rong Wang, PhD, senior author on the study, associate professor and director of the Laboratory for Accelerated Vascular Research and Mildred V. Strouss Endowed Chair in Vascular Surgery at UCSF. "Furthermore, we found that repression of the gene in already-ill mice led to their recovery."


'/>"/>
Contact: Lauren Hammit
lhammit@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Thawing permafrost likely to boost global warming
2. Extinction most likely for rare trees in the Amazon rainforest
3. Likely cause of postpartum blues and depression identified
4. Stem cell chicken and egg debate moves to unlikely arena: the testes
5. Revolutionary chefs? Not likely, shows physics research
6. U of M research finds teens who have TV in their bedroom are less likely to engage in healthy habits
7. Baby boys are more likely to die than baby girls
8. Unfavorable ocean conditions likely cause of low 2007 salmon returns along West Coast
9. New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets
10. Coral reefs unlikely to survive in acid oceans
11. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... 21, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market ... that it has filed provisional patent 62/192218 for ... This invention highlights next generation payment ... account, but also the user using unique personal ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 30, 2015 after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:7/8/2015)... , N.J. and NEW YORK , ... and Guidepoint today announced BD & ... healthcare companies with free access to Guidepoint,s expert network ... start-ups that are developing cutting-edge technologies to improve healthcare ... dedicated Guidepoint research manager, each start-up entrepreneur will be ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... Director of the United States Department of Agriculture National ... the Monell Center,s Kerry-Manheimer Award. The Award will be ... Since 1976, the annual Kerry-Manheimer Award has recognized ... sciences. The honoree traditionally spends the Award day meeting ...
... Md - If you,ve owned a pet guppy, you know they ... why the guppy jumped; many a parent has been stumped for ... Daphne Soares reveals how guppies are able to jump so far, ... the brain circuitry that controls animal behavior, decided to study jumping ...
... 2013: Probiotics could emerge as a treatment plan ... new study announced at the International Liver ... the notoriously difficult-to-treat disease. The study analysed ... of HE in 160 cirrhotic patients over a ...
Cached Biology News:Monell alum Dr. Larry Clark named Center's 2013 Kerry-Manheimer awardee 2Why do guppies jump? 2Probiotics found to reduce hepatic encephalopathy 2
(Date:7/29/2015)... TX (PRWEB) , ... July 29, 2015 , ... ... designer, manufacturer and supplier, announces the launch of their 2nd generation cell therapy ... the current miniPOD CT, but it also represents a new POD® design. ...
(Date:7/29/2015)... , July 29, 2015  AmnioChor Inc., an ... technology, is very pleased to announce that the Musculoskeletal ... has agreed to invest in their seed round of ... placental tissue storage capabilities. AmnioChor,s technology ... and the human stem cells living within those tissues. ...
(Date:7/29/2015)... England , July 29, 2015  Indivior PLC ... (NDA) for naloxone nasal spray was accepted and received ... (FDA) for the treatment of opioid overdose. This naloxone ... naloxone specially formulated for optimal absorption into the nasal ... require minimal training so individuals may be better equipped ...
(Date:7/29/2015)... CITY , July 29, 2015 /PRNewswire/ - Aeterna ... today announced it has selected an optimized Erk ... milestone in the development of a new class ... MAPK pathway represents a prime target for therapeutic ... antitumor activities and survival benefits for B-Raf and ...
Breaking Biology Technology:G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3
... October 8, 2010 VIB researchers at the University of ... in the development of Hereditary Sensory and Autonomous Neuropathy Type ... of the peripheral nervous system. Identification of the mutations will ... patients as well as improved genetic counseling and prenatal diagnostic ...
... Eui-Hyeok Yang, Associate Professor of Mechanical Engineering and Director ... of Technology, The Innovation University (TM), will receive funding ... of a Nanoimprint Lithography System (NIL) for the purpose ... at Stevens. The Co-PIs of the project are Drs. ...
... Cumberland Pharmaceuticals Inc. (Nasdaq: CPIX) today ... safety and efficacy of Caldolor® ( ibuprofen ) Injection ... adults. Published in the peer-reviewed journal Critical Care ... more effective at reducing fever in hospitalized patients than ...
Cached Biology Technology:HSAN 1: Identification of new mutations, more accurate diagnosis and improved genetic counseling 2Nanoimprint lithography NSF grant awarded to micro device lab at Stevens 2Nanoimprint lithography NSF grant awarded to micro device lab at Stevens 3Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 2Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 3Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 4
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The ProteinChip beta-amyloid Multipeptide Kit, ... Systems, makes detecting a variety of ... than ever before. - Clinical neuroscience ... after drug treatment - Correlate beta-amyloid ...
Formula variant: With the macro- and micronutrients as described by Lloyd and McCown (1981). Preparation Quantity Equivalency: Formulated to contain 2.3 grams of powder per liter of medium. Physical ...
... Biosystems and MDS Sciex present the ... high performance hybrid triple quadrupole/linear ion ... discovery, drug development or proteomics researcher. ... from the leaders in mass spectrometry ...
Biology Products: