Navigation Links
Gene is likely cause of stroke-inducing vascular malformations
Date:9/2/2008

UCSF scientists have discovered that a gene controlling whether blood vessels differentiate into arteries or veins during embryonic development is linked to a vascular disorder in the brain that causes stroke.

The UCSF studies were done in mice, and the new findings are the first to provide information on both the progression and regression of this particular brain disorder, known as BAVM, and to provide molecular clues into the disease, which is not well-understood and chiefly affects young people.

BAVM, for brain arteriovenous malformation, is a vascular disorder causing arteries and veins to be directly connected, rather than through capillaries. This direct connection produces enlarged, tangled masses of vessels that are prone to hemorrhagic rupture, bleeding and stroke. Because they develop most often in growing tissues, BAVMs are responsible for half of the hemorrhagic strokes in children.

Study findings were published in a recent issue (Aug. 5, 2008) of the Proceedings of the National Academy of Sciences.

The UCSF team identified the gene, known as Notch, as a potential cause of BAVMs because of its role in directing embryonic blood vessel formation. Using genetic tools, the team "turned on" a constantly active Notch gene in endothelial brain cells, which are the cells lining blood vessels in the brain, and found that BAVMs were induced. When researchers turned the gene off, the mice exhibited full recovery from the disease's progression.

"This was exciting. The activated Notch gene caused BAVM in all of the mice, making it an unprecedented, potent molecular lesion in the induction of the pathology," said Rong Wang, PhD, senior author on the study, associate professor and director of the Laboratory for Accelerated Vascular Research and Mildred V. Strouss Endowed Chair in Vascular Surgery at UCSF. "Furthermore, we found that repression of the gene in already-ill mice led to their recovery."


'/>"/>
Contact: Lauren Hammit
lhammit@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Thawing permafrost likely to boost global warming
2. Extinction most likely for rare trees in the Amazon rainforest
3. Likely cause of postpartum blues and depression identified
4. Stem cell chicken and egg debate moves to unlikely arena: the testes
5. Revolutionary chefs? Not likely, shows physics research
6. U of M research finds teens who have TV in their bedroom are less likely to engage in healthy habits
7. Baby boys are more likely to die than baby girls
8. Unfavorable ocean conditions likely cause of low 2007 salmon returns along West Coast
9. New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets
10. Coral reefs unlikely to survive in acid oceans
11. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
(Date:4/17/2014)... forests are chock full of wild animals and plant ... of fungi are churning away in the soil, decomposing ... Despite the vital role these fungi play in ecological ... Stanford-led team of scientists has generated a genetic map ... America. The work was published this week in the ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... of Energy,s Oak Ridge National Laboratory to analyze a simple ... understand more complex microbial communities such as those found in ... Proceedings of the National Academy of Sciences , a multi-institutional ... known as Olavius algarvensis. The worm lacks a digestive system ...
... While we often think of memory as a way of ... is given to the importance of forgetting to our wellbeing, ... or just reflects the minutia of day-to-day living. ... forgetthe molecular, cellular, and brain circuit mechanisms underlying the processis ...
... (May 9, 2012) Like their human cousins, orangutans ... it. If the menu,s right, giraffes are even less picky. ... Brown School of Engineering have designed devices to efficiently, durably, ... different residents of the Houston Zoo. "For the orangutans, ...
Cached Biology News:ORNL protein analysis investigates marine worm community 2Scripps Florida scientists identify neurotranmitters that lead to forgetting 2Scripps Florida scientists identify neurotranmitters that lead to forgetting 3Feeding without the frenzy 2
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused on ... of tumor cells in the bloodstream, today announced that ... support application powered by CollabRx, Inc. , Available ... Therapy Finder will provide breast cancer patients and their ...
(Date:1/15/2014)... 15, 2014 This webinar will focus ... clinical safety assessment in biosimilars. , Regulatory frameworks are ... drug development, however the complex nature of biopharmaceuticals makes ... and efficacy extremely challenging. Based on the specific aspects ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... 11 The following is,GlaxoSmithKline,s (NYSE: ... by the,Institute for Clinical Evaluative Sciences (ICES) ... with,Diabetes"., GSK believes that the ICES ... database has significant limitations and generates misleading,conclusions ...
... today announced its,latest findings regarding the virus replikin ... analysis has found that the prevalence,of these sequences ... now have been found in China. These statistics ... linked to the lethality of,influenza viruses. When factored ...
... Dec. 11 Lucid, Inc., (http://www.lucid-tech.com ), a ... Dr. Colin Stahel as Director, Asia Pacific Region., ... for the newly created,position based on his extensive ... of experience in the development of medical,technology and ...
Cached Biology Technology:GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 2GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 3GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 4GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 5Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated 2Lucid Expands Support Internationally: Dr. Colin Stahel appointed Director for Asia Pacific Region 2
...
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... Slotted migration Chamber lid allows ... One-touch connectors for easy set up ... Magnetic safety-switch prevents current flow if the lid ... Excellent safety and durability., Remote control ...
... Black wall plates have low ... reduced crosstalk,• Not treated (or medium ... nature and binds biomolecules through passive ... the immobilization of large molecules, such ...
Biology Products: