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Gene involved in sperm-to-egg binding is key to fertility in mammals
Date:4/30/2012

Experts from Durham University have identified a new gene that could help the development of fertility treatments in humans in the future.

Scientists from Durham University, UK, and Osaka University, Japan, looking at fertility in mice, have discovered for the first time that the gene, which makes a protein called PDILT, enables sperm to bind to an egg, a process essential to fertilisation.

The team found that when the gene was 'switched off' in male mice, less than three per cent of females' eggs were fertilised compared to more than 80 per cent in mice when the gene was left switched on.

It is the first time that a gene of this type has been linked to fertility.

The researchers also found that the cumulus cells, a cluster of cells surrounding and protecting an egg, play an important role in fertility - their presence enables sperm to bind properly to an egg.

Although the research and findings are at an early stage, the researchers now hope to look at how the gene affects sperm-to-egg binding in humans. The findings are published in the journal PNAS, Proceedings of the National Academy of Sciences.

The discoveries could pave the way for the development of new fertility treatments for humans that could help to reduce the cost and improve the effectiveness of in vitro fertilisation (IVF). They could also assist research into new contraceptive techniques that deactivate the gene and prevent sperm reaching an egg and binding to it.

Dr Adam Benham, School of Biological and Biomedical Sciences, Durham University, said: "The protein is an essential part of the navigation system of sperm. It helps sperm swim through the oviduct to the egg and without it sperm get stuck. Our results show that navigating the oviduct is an important part of the fertilisation process.

"Like any navigation system, you have to programme where it is that you want to go and this protein plays an essential role
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Contact: Media Relations
c.r.stiansen@durham.ac.uk
44-191-334-6075
Durham University
Source:Eurekalert

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